Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview
Marijuana, or Cannabis sativa L., is a common psychoactive plant used for both recreational and medicinal purposes. In many countries, cannabis‐based medicines have been legalized under certain conditions because of their immense prospects in medicinal applications. With a comprehensive insight into...
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| Veröffentlicht in: | Phytotherapy research 2021-11, Vol.35 (11), p.6010-6029 |
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| creator | Kumar, Pradeep Mahato, Dipendra Kumar Kamle, Madhu Borah, Rituraj Sharma, Bharti Pandhi, Shikha Tripathi, Vijay Yadav, Hardeo Singh Devi, Sheetal Patil, Umesh Xiao, Jianbo Mishra, Awdhesh Kumar |
| description | Marijuana, or Cannabis sativa L., is a common psychoactive plant used for both recreational and medicinal purposes. In many countries, cannabis‐based medicines have been legalized under certain conditions because of their immense prospects in medicinal applications. With a comprehensive insight into the prospects and challenges associated with the pharmacological use and global trade of C. sativa, this mini‐review focuses on the medicinal importance of the plant and its legal status worldwide; the pharmacological compounds and its therapeutic potential along with the underlying public health concerns and future perspective are herein discussed. The existence of major compounds including Δ9‐tetrahydrocannabinol (Δ9‐THC), cannabidiol, cannabinol, and cannabichromene contributes to the medicinal effects of the cannabis plant. These compounds are also involved in the treatment of various types of cancer, epilepsy, and Parkinson's disease displaying several mechanisms of action. Cannabis sativa is a plant with significant pharmacological potential. However, several aspects of the plant need an in‐depth understanding of the drug mechanism and its interaction with other drugs. Only after addressing these health concerns, legalization of cannabis could be utilized to its full potential as a future medicine. |
| doi_str_mv | 10.1002/ptr.7213 |
| format | Article |
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In many countries, cannabis‐based medicines have been legalized under certain conditions because of their immense prospects in medicinal applications. With a comprehensive insight into the prospects and challenges associated with the pharmacological use and global trade of C. sativa, this mini‐review focuses on the medicinal importance of the plant and its legal status worldwide; the pharmacological compounds and its therapeutic potential along with the underlying public health concerns and future perspective are herein discussed. The existence of major compounds including Δ9‐tetrahydrocannabinol (Δ9‐THC), cannabidiol, cannabinol, and cannabichromene contributes to the medicinal effects of the cannabis plant. These compounds are also involved in the treatment of various types of cancer, epilepsy, and Parkinson's disease displaying several mechanisms of action. Cannabis sativa is a plant with significant pharmacological potential. However, several aspects of the plant need an in‐depth understanding of the drug mechanism and its interaction with other drugs. Only after addressing these health concerns, legalization of cannabis could be utilized to its full potential as a future medicine.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.7213</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>anticancer ; C. sativa ; Cannabinoids ; Cannabis ; Cannabis sativa ; Chemical compounds ; Drug interaction ; Epilepsy ; ethnopharmacological properties ; International trade ; legalization ; Marijuana ; Medicinal plants ; Medicine ; Movement disorders ; Neurodegenerative diseases ; Parkinson's disease ; Pharmacology ; psychoactive drug ; Public health ; Tetrahydrocannabinol</subject><ispartof>Phytotherapy research, 2021-11, Vol.35 (11), p.6010-6029</ispartof><rights>2021 John Wiley & Sons Ltd.</rights><rights>2021 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3263-601c2d3959fe2268ec8630be23a79ac871bda3964efeb0115973b715c195d0ad3</citedby><cites>FETCH-LOGICAL-c3263-601c2d3959fe2268ec8630be23a79ac871bda3964efeb0115973b715c195d0ad3</cites><orcidid>0000-0001-8857-2326 ; 0000-0002-0892-5425</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.7213$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.7213$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Kumar, Pradeep</creatorcontrib><creatorcontrib>Mahato, Dipendra Kumar</creatorcontrib><creatorcontrib>Kamle, Madhu</creatorcontrib><creatorcontrib>Borah, Rituraj</creatorcontrib><creatorcontrib>Sharma, Bharti</creatorcontrib><creatorcontrib>Pandhi, Shikha</creatorcontrib><creatorcontrib>Tripathi, Vijay</creatorcontrib><creatorcontrib>Yadav, Hardeo Singh</creatorcontrib><creatorcontrib>Devi, Sheetal</creatorcontrib><creatorcontrib>Patil, Umesh</creatorcontrib><creatorcontrib>Xiao, Jianbo</creatorcontrib><creatorcontrib>Mishra, Awdhesh Kumar</creatorcontrib><title>Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview</title><title>Phytotherapy research</title><description>Marijuana, or Cannabis sativa L., is a common psychoactive plant used for both recreational and medicinal purposes. In many countries, cannabis‐based medicines have been legalized under certain conditions because of their immense prospects in medicinal applications. With a comprehensive insight into the prospects and challenges associated with the pharmacological use and global trade of C. sativa, this mini‐review focuses on the medicinal importance of the plant and its legal status worldwide; the pharmacological compounds and its therapeutic potential along with the underlying public health concerns and future perspective are herein discussed. The existence of major compounds including Δ9‐tetrahydrocannabinol (Δ9‐THC), cannabidiol, cannabinol, and cannabichromene contributes to the medicinal effects of the cannabis plant. These compounds are also involved in the treatment of various types of cancer, epilepsy, and Parkinson's disease displaying several mechanisms of action. Cannabis sativa is a plant with significant pharmacological potential. However, several aspects of the plant need an in‐depth understanding of the drug mechanism and its interaction with other drugs. Only after addressing these health concerns, legalization of cannabis could be utilized to its full potential as a future medicine.</description><subject>anticancer</subject><subject>C. sativa</subject><subject>Cannabinoids</subject><subject>Cannabis</subject><subject>Cannabis sativa</subject><subject>Chemical compounds</subject><subject>Drug interaction</subject><subject>Epilepsy</subject><subject>ethnopharmacological properties</subject><subject>International trade</subject><subject>legalization</subject><subject>Marijuana</subject><subject>Medicinal plants</subject><subject>Medicine</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson's disease</subject><subject>Pharmacology</subject><subject>psychoactive drug</subject><subject>Public health</subject><subject>Tetrahydrocannabinol</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10E9r3DAQBXBRUugmDeQjCHLJId7OSGt71VtY-g8WEkoCuYmxPE4UvJYjyRvy7es0gUIhp7n8eLx5QpwgLBFAfRlzXNYK9QexQDCmwLLWB2IBpsRihevbT-IwpQcAMApWC9Fd3VPckQt9uPOOejnGMHLMntO5zPccaeQpeyfHkHnInvpzSUMre76bccqUpyRDJzc0DNT4JBNlvye5XX6VF4MMe457z0-fxceO-sTHb_dI3Hz_dr35WWwvf_zaXGwLp1WliwrQqVab0nSsVLVmt640NKw01YbcusamJW2qFXfcAGJpat3UWDo0ZQvU6iNx9po7v_E4ccp255PjvqeBw5SsKktQFZgKZnr6H30IUxzmdnYWiAha479AF0NKkTs7Rr-j-GwR7Mvgdh7cvgw-0-KVPvmen9919ur691__B-gMgUA</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Kumar, Pradeep</creator><creator>Mahato, Dipendra Kumar</creator><creator>Kamle, Madhu</creator><creator>Borah, Rituraj</creator><creator>Sharma, Bharti</creator><creator>Pandhi, Shikha</creator><creator>Tripathi, Vijay</creator><creator>Yadav, Hardeo Singh</creator><creator>Devi, Sheetal</creator><creator>Patil, Umesh</creator><creator>Xiao, Jianbo</creator><creator>Mishra, Awdhesh Kumar</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8857-2326</orcidid><orcidid>https://orcid.org/0000-0002-0892-5425</orcidid></search><sort><creationdate>202111</creationdate><title>Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview</title><author>Kumar, Pradeep ; Mahato, Dipendra Kumar ; Kamle, Madhu ; Borah, Rituraj ; Sharma, Bharti ; Pandhi, Shikha ; Tripathi, Vijay ; Yadav, Hardeo Singh ; Devi, Sheetal ; Patil, Umesh ; Xiao, Jianbo ; Mishra, Awdhesh Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3263-601c2d3959fe2268ec8630be23a79ac871bda3964efeb0115973b715c195d0ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>anticancer</topic><topic>C. sativa</topic><topic>Cannabinoids</topic><topic>Cannabis</topic><topic>Cannabis sativa</topic><topic>Chemical compounds</topic><topic>Drug interaction</topic><topic>Epilepsy</topic><topic>ethnopharmacological properties</topic><topic>International trade</topic><topic>legalization</topic><topic>Marijuana</topic><topic>Medicinal plants</topic><topic>Medicine</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Parkinson's disease</topic><topic>Pharmacology</topic><topic>psychoactive drug</topic><topic>Public health</topic><topic>Tetrahydrocannabinol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Pradeep</creatorcontrib><creatorcontrib>Mahato, Dipendra Kumar</creatorcontrib><creatorcontrib>Kamle, Madhu</creatorcontrib><creatorcontrib>Borah, Rituraj</creatorcontrib><creatorcontrib>Sharma, Bharti</creatorcontrib><creatorcontrib>Pandhi, Shikha</creatorcontrib><creatorcontrib>Tripathi, Vijay</creatorcontrib><creatorcontrib>Yadav, Hardeo Singh</creatorcontrib><creatorcontrib>Devi, Sheetal</creatorcontrib><creatorcontrib>Patil, Umesh</creatorcontrib><creatorcontrib>Xiao, Jianbo</creatorcontrib><creatorcontrib>Mishra, Awdhesh Kumar</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Pradeep</au><au>Mahato, Dipendra Kumar</au><au>Kamle, Madhu</au><au>Borah, Rituraj</au><au>Sharma, Bharti</au><au>Pandhi, Shikha</au><au>Tripathi, Vijay</au><au>Yadav, Hardeo Singh</au><au>Devi, Sheetal</au><au>Patil, Umesh</au><au>Xiao, Jianbo</au><au>Mishra, Awdhesh Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview</atitle><jtitle>Phytotherapy research</jtitle><date>2021-11</date><risdate>2021</risdate><volume>35</volume><issue>11</issue><spage>6010</spage><epage>6029</epage><pages>6010-6029</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Marijuana, or Cannabis sativa L., is a common psychoactive plant used for both recreational and medicinal purposes. 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| subjects | anticancer C. sativa Cannabinoids Cannabis Cannabis sativa Chemical compounds Drug interaction Epilepsy ethnopharmacological properties International trade legalization Marijuana Medicinal plants Medicine Movement disorders Neurodegenerative diseases Parkinson's disease Pharmacology psychoactive drug Public health Tetrahydrocannabinol |
| title | Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview |
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