Neural correlates of fear conditioning and fear extinction and its association with cognitive-behavioral therapy outcome in adults with obsessive-compulsive disorder
Recent neurobiological models of obsessive-compulsive disorder (OCD) have highlighted the potential role of abnormalities in fear learning processes. We compared brain activation -as assessed with whole-brain functional magnetic resonance imaging- during fear conditioning, fear extinction learning,...
Gespeichert in:
| Veröffentlicht in: | Behaviour research and therapy 2021-09, Vol.144, p.103927-103927, Article 103927 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 103927 |
|---|---|
| container_issue | |
| container_start_page | 103927 |
| container_title | Behaviour research and therapy |
| container_volume | 144 |
| creator | Cano, Marta Martínez-Zalacaín, Ignacio Giménez, Mònica Torrents-Rodas, David Real, Eva Alonso, Pino Segalàs, Cinto Munuera, Josep Menchón, José Manuel Cardoner, Narcís Soriano-Mas, Carles Fullana, Miquel A. |
| description | Recent neurobiological models of obsessive-compulsive disorder (OCD) have highlighted the potential role of abnormalities in fear learning processes. We compared brain activation -as assessed with whole-brain functional magnetic resonance imaging- during fear conditioning, fear extinction learning, and fear extinction recall in patients with OCD (n = 18) and healthy controls (n = 18). We also investigated whether brain activation during any of these processes was associated with exposure-based cognitive-behavioral therapy (CBT) outcome in patients. Patients with OCD showed significantly lower brain activation in the right insulo-opercular region and the dorsal anterior cingulate cortex during fear conditioning in comparison to healthy controls. Moreover, brain activation in the right insula predicted CBT outcome, with lower activation predicting a better outcome. Brain activation during extinction learning or recall did not differ between patients and controls or predicted CBT outcome in patients. Our results suggest that neural activations during fear conditioning in patients with OCD are abnormal and predict CBT outcome.
•We studied the neural correlates of fear learning processes in OCD.•Patients with OCD showed abnormal brain activation during fear conditioning.•Brain activation during conditioning predicted cognitive-behaviour therapy outcome. |
| doi_str_mv | 10.1016/j.brat.2021.103927 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2550260718</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0005796721001261</els_id><sourcerecordid>2550260718</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-8c5508ab2743976659d0ddd1474ace1ae1bacd2269542c66c0b8953f0efb0f223</originalsourceid><addsrcrecordid>eNp9kcFu1DAURS0EEkPpD7CKxIZNpvZL4iQSG1RRQKpgQ6XuLMd-6XiUsQc_Z6AfxH_WmXTFgpXt63vus3UZeyf4VnAhr_bbIeq0BQ4iC1UP7Qu2EV1blRLg_iXbcM6bsu1l-5q9IdrnY9UB37C_33GOeipMiBEnnZCKMBYj6pglb11ywTv_UGhvVxX_JOfNIp81l6jQRME4fdZ-u7TL5IPP5AnLAXf65MIyIe0w6uNjEeZkwgELlwPsPGX-zISBkGhh8u1xnpZtYR2FaDG-Za9GPRFePq8X7O7m88_rr-Xtjy_frj_dlqYWTSo70zS80wO0ddW3Uja95dZaUbe1Nig0ikEbCyD7pgYjpeFD1zfVyHEc-AhQXbAPa-4xhl8zUlIHRwanSXsMMynI-SB5K7psff-PdR_m6PPrsiuPBhBdn12wukwMRBFHdYzuoOOjElwtzam9WppTS3NqbS5DH1cI81dPDqMi49AbtC6iScoG9z_8Cdl7pjU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2566522189</pqid></control><display><type>article</type><title>Neural correlates of fear conditioning and fear extinction and its association with cognitive-behavioral therapy outcome in adults with obsessive-compulsive disorder</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Elsevier ScienceDirect Journals</source><creator>Cano, Marta ; Martínez-Zalacaín, Ignacio ; Giménez, Mònica ; Torrents-Rodas, David ; Real, Eva ; Alonso, Pino ; Segalàs, Cinto ; Munuera, Josep ; Menchón, José Manuel ; Cardoner, Narcís ; Soriano-Mas, Carles ; Fullana, Miquel A.</creator><creatorcontrib>Cano, Marta ; Martínez-Zalacaín, Ignacio ; Giménez, Mònica ; Torrents-Rodas, David ; Real, Eva ; Alonso, Pino ; Segalàs, Cinto ; Munuera, Josep ; Menchón, José Manuel ; Cardoner, Narcís ; Soriano-Mas, Carles ; Fullana, Miquel A.</creatorcontrib><description>Recent neurobiological models of obsessive-compulsive disorder (OCD) have highlighted the potential role of abnormalities in fear learning processes. We compared brain activation -as assessed with whole-brain functional magnetic resonance imaging- during fear conditioning, fear extinction learning, and fear extinction recall in patients with OCD (n = 18) and healthy controls (n = 18). We also investigated whether brain activation during any of these processes was associated with exposure-based cognitive-behavioral therapy (CBT) outcome in patients. Patients with OCD showed significantly lower brain activation in the right insulo-opercular region and the dorsal anterior cingulate cortex during fear conditioning in comparison to healthy controls. Moreover, brain activation in the right insula predicted CBT outcome, with lower activation predicting a better outcome. Brain activation during extinction learning or recall did not differ between patients and controls or predicted CBT outcome in patients. Our results suggest that neural activations during fear conditioning in patients with OCD are abnormal and predict CBT outcome.
•We studied the neural correlates of fear learning processes in OCD.•Patients with OCD showed abnormal brain activation during fear conditioning.•Brain activation during conditioning predicted cognitive-behaviour therapy outcome.</description><identifier>ISSN: 0005-7967</identifier><identifier>EISSN: 1873-622X</identifier><identifier>DOI: 10.1016/j.brat.2021.103927</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Behavior modification ; Brain mapping ; Cognitive ability ; Cognitive behavioral therapy ; Cognitive therapy ; Cognitive-behavioral factors ; Conditioning ; Cortex ; Cortex (cingulate) ; Extinction ; Extinction behavior ; Fear & phobias ; Fear conditioning ; Fear extinction ; fMRI ; Functional magnetic resonance imaging ; Insula ; Learning ; Learning processes ; Neuroimaging ; Neuroses ; Obsessive compulsive disorder ; Professional associations ; Psychological extinction</subject><ispartof>Behaviour research and therapy, 2021-09, Vol.144, p.103927-103927, Article 103927</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright Pergamon Press Inc. Sep 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-8c5508ab2743976659d0ddd1474ace1ae1bacd2269542c66c0b8953f0efb0f223</citedby><cites>FETCH-LOGICAL-c415t-8c5508ab2743976659d0ddd1474ace1ae1bacd2269542c66c0b8953f0efb0f223</cites><orcidid>0000-0001-5154-1796 ; 0000-0002-5779-9111 ; 0000-0003-0675-9483</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0005796721001261$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,30978,65309</link.rule.ids></links><search><creatorcontrib>Cano, Marta</creatorcontrib><creatorcontrib>Martínez-Zalacaín, Ignacio</creatorcontrib><creatorcontrib>Giménez, Mònica</creatorcontrib><creatorcontrib>Torrents-Rodas, David</creatorcontrib><creatorcontrib>Real, Eva</creatorcontrib><creatorcontrib>Alonso, Pino</creatorcontrib><creatorcontrib>Segalàs, Cinto</creatorcontrib><creatorcontrib>Munuera, Josep</creatorcontrib><creatorcontrib>Menchón, José Manuel</creatorcontrib><creatorcontrib>Cardoner, Narcís</creatorcontrib><creatorcontrib>Soriano-Mas, Carles</creatorcontrib><creatorcontrib>Fullana, Miquel A.</creatorcontrib><title>Neural correlates of fear conditioning and fear extinction and its association with cognitive-behavioral therapy outcome in adults with obsessive-compulsive disorder</title><title>Behaviour research and therapy</title><description>Recent neurobiological models of obsessive-compulsive disorder (OCD) have highlighted the potential role of abnormalities in fear learning processes. We compared brain activation -as assessed with whole-brain functional magnetic resonance imaging- during fear conditioning, fear extinction learning, and fear extinction recall in patients with OCD (n = 18) and healthy controls (n = 18). We also investigated whether brain activation during any of these processes was associated with exposure-based cognitive-behavioral therapy (CBT) outcome in patients. Patients with OCD showed significantly lower brain activation in the right insulo-opercular region and the dorsal anterior cingulate cortex during fear conditioning in comparison to healthy controls. Moreover, brain activation in the right insula predicted CBT outcome, with lower activation predicting a better outcome. Brain activation during extinction learning or recall did not differ between patients and controls or predicted CBT outcome in patients. Our results suggest that neural activations during fear conditioning in patients with OCD are abnormal and predict CBT outcome.
•We studied the neural correlates of fear learning processes in OCD.•Patients with OCD showed abnormal brain activation during fear conditioning.•Brain activation during conditioning predicted cognitive-behaviour therapy outcome.</description><subject>Behavior modification</subject><subject>Brain mapping</subject><subject>Cognitive ability</subject><subject>Cognitive behavioral therapy</subject><subject>Cognitive therapy</subject><subject>Cognitive-behavioral factors</subject><subject>Conditioning</subject><subject>Cortex</subject><subject>Cortex (cingulate)</subject><subject>Extinction</subject><subject>Extinction behavior</subject><subject>Fear & phobias</subject><subject>Fear conditioning</subject><subject>Fear extinction</subject><subject>fMRI</subject><subject>Functional magnetic resonance imaging</subject><subject>Insula</subject><subject>Learning</subject><subject>Learning processes</subject><subject>Neuroimaging</subject><subject>Neuroses</subject><subject>Obsessive compulsive disorder</subject><subject>Professional associations</subject><subject>Psychological extinction</subject><issn>0005-7967</issn><issn>1873-622X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNp9kcFu1DAURS0EEkPpD7CKxIZNpvZL4iQSG1RRQKpgQ6XuLMd-6XiUsQc_Z6AfxH_WmXTFgpXt63vus3UZeyf4VnAhr_bbIeq0BQ4iC1UP7Qu2EV1blRLg_iXbcM6bsu1l-5q9IdrnY9UB37C_33GOeipMiBEnnZCKMBYj6pglb11ywTv_UGhvVxX_JOfNIp81l6jQRME4fdZ-u7TL5IPP5AnLAXf65MIyIe0w6uNjEeZkwgELlwPsPGX-zISBkGhh8u1xnpZtYR2FaDG-Za9GPRFePq8X7O7m88_rr-Xtjy_frj_dlqYWTSo70zS80wO0ddW3Uja95dZaUbe1Nig0ikEbCyD7pgYjpeFD1zfVyHEc-AhQXbAPa-4xhl8zUlIHRwanSXsMMynI-SB5K7psff-PdR_m6PPrsiuPBhBdn12wukwMRBFHdYzuoOOjElwtzam9WppTS3NqbS5DH1cI81dPDqMi49AbtC6iScoG9z_8Cdl7pjU</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Cano, Marta</creator><creator>Martínez-Zalacaín, Ignacio</creator><creator>Giménez, Mònica</creator><creator>Torrents-Rodas, David</creator><creator>Real, Eva</creator><creator>Alonso, Pino</creator><creator>Segalàs, Cinto</creator><creator>Munuera, Josep</creator><creator>Menchón, José Manuel</creator><creator>Cardoner, Narcís</creator><creator>Soriano-Mas, Carles</creator><creator>Fullana, Miquel A.</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5154-1796</orcidid><orcidid>https://orcid.org/0000-0002-5779-9111</orcidid><orcidid>https://orcid.org/0000-0003-0675-9483</orcidid></search><sort><creationdate>20210901</creationdate><title>Neural correlates of fear conditioning and fear extinction and its association with cognitive-behavioral therapy outcome in adults with obsessive-compulsive disorder</title><author>Cano, Marta ; Martínez-Zalacaín, Ignacio ; Giménez, Mònica ; Torrents-Rodas, David ; Real, Eva ; Alonso, Pino ; Segalàs, Cinto ; Munuera, Josep ; Menchón, José Manuel ; Cardoner, Narcís ; Soriano-Mas, Carles ; Fullana, Miquel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-8c5508ab2743976659d0ddd1474ace1ae1bacd2269542c66c0b8953f0efb0f223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Behavior modification</topic><topic>Brain mapping</topic><topic>Cognitive ability</topic><topic>Cognitive behavioral therapy</topic><topic>Cognitive therapy</topic><topic>Cognitive-behavioral factors</topic><topic>Conditioning</topic><topic>Cortex</topic><topic>Cortex (cingulate)</topic><topic>Extinction</topic><topic>Extinction behavior</topic><topic>Fear & phobias</topic><topic>Fear conditioning</topic><topic>Fear extinction</topic><topic>fMRI</topic><topic>Functional magnetic resonance imaging</topic><topic>Insula</topic><topic>Learning</topic><topic>Learning processes</topic><topic>Neuroimaging</topic><topic>Neuroses</topic><topic>Obsessive compulsive disorder</topic><topic>Professional associations</topic><topic>Psychological extinction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cano, Marta</creatorcontrib><creatorcontrib>Martínez-Zalacaín, Ignacio</creatorcontrib><creatorcontrib>Giménez, Mònica</creatorcontrib><creatorcontrib>Torrents-Rodas, David</creatorcontrib><creatorcontrib>Real, Eva</creatorcontrib><creatorcontrib>Alonso, Pino</creatorcontrib><creatorcontrib>Segalàs, Cinto</creatorcontrib><creatorcontrib>Munuera, Josep</creatorcontrib><creatorcontrib>Menchón, José Manuel</creatorcontrib><creatorcontrib>Cardoner, Narcís</creatorcontrib><creatorcontrib>Soriano-Mas, Carles</creatorcontrib><creatorcontrib>Fullana, Miquel A.</creatorcontrib><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behaviour research and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cano, Marta</au><au>Martínez-Zalacaín, Ignacio</au><au>Giménez, Mònica</au><au>Torrents-Rodas, David</au><au>Real, Eva</au><au>Alonso, Pino</au><au>Segalàs, Cinto</au><au>Munuera, Josep</au><au>Menchón, José Manuel</au><au>Cardoner, Narcís</au><au>Soriano-Mas, Carles</au><au>Fullana, Miquel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural correlates of fear conditioning and fear extinction and its association with cognitive-behavioral therapy outcome in adults with obsessive-compulsive disorder</atitle><jtitle>Behaviour research and therapy</jtitle><date>2021-09-01</date><risdate>2021</risdate><volume>144</volume><spage>103927</spage><epage>103927</epage><pages>103927-103927</pages><artnum>103927</artnum><issn>0005-7967</issn><eissn>1873-622X</eissn><abstract>Recent neurobiological models of obsessive-compulsive disorder (OCD) have highlighted the potential role of abnormalities in fear learning processes. We compared brain activation -as assessed with whole-brain functional magnetic resonance imaging- during fear conditioning, fear extinction learning, and fear extinction recall in patients with OCD (n = 18) and healthy controls (n = 18). We also investigated whether brain activation during any of these processes was associated with exposure-based cognitive-behavioral therapy (CBT) outcome in patients. Patients with OCD showed significantly lower brain activation in the right insulo-opercular region and the dorsal anterior cingulate cortex during fear conditioning in comparison to healthy controls. Moreover, brain activation in the right insula predicted CBT outcome, with lower activation predicting a better outcome. Brain activation during extinction learning or recall did not differ between patients and controls or predicted CBT outcome in patients. Our results suggest that neural activations during fear conditioning in patients with OCD are abnormal and predict CBT outcome.
•We studied the neural correlates of fear learning processes in OCD.•Patients with OCD showed abnormal brain activation during fear conditioning.•Brain activation during conditioning predicted cognitive-behaviour therapy outcome.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.brat.2021.103927</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5154-1796</orcidid><orcidid>https://orcid.org/0000-0002-5779-9111</orcidid><orcidid>https://orcid.org/0000-0003-0675-9483</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0005-7967 |
| ispartof | Behaviour research and therapy, 2021-09, Vol.144, p.103927-103927, Article 103927 |
| issn | 0005-7967 1873-622X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2550260718 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Elsevier ScienceDirect Journals |
| subjects | Behavior modification Brain mapping Cognitive ability Cognitive behavioral therapy Cognitive therapy Cognitive-behavioral factors Conditioning Cortex Cortex (cingulate) Extinction Extinction behavior Fear & phobias Fear conditioning Fear extinction fMRI Functional magnetic resonance imaging Insula Learning Learning processes Neuroimaging Neuroses Obsessive compulsive disorder Professional associations Psychological extinction |
| title | Neural correlates of fear conditioning and fear extinction and its association with cognitive-behavioral therapy outcome in adults with obsessive-compulsive disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A48%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neural%20correlates%20of%20fear%20conditioning%20and%20fear%20extinction%20and%20its%20association%20with%20cognitive-behavioral%20therapy%20outcome%20in%20adults%20with%20obsessive-compulsive%20disorder&rft.jtitle=Behaviour%20research%20and%20therapy&rft.au=Cano,%20Marta&rft.date=2021-09-01&rft.volume=144&rft.spage=103927&rft.epage=103927&rft.pages=103927-103927&rft.artnum=103927&rft.issn=0005-7967&rft.eissn=1873-622X&rft_id=info:doi/10.1016/j.brat.2021.103927&rft_dat=%3Cproquest_cross%3E2550260718%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2566522189&rft_id=info:pmid/&rft_els_id=S0005796721001261&rfr_iscdi=true |