The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2

ALS2, a product of the causative gene for familial amyotrophic lateral sclerosis (ALS) type 2, plays a pivotal role in the regulation of endosome dynamics by activating small GTPase Rab5 via its intrinsic guanine nucleotide-exchange factor activity. Previously, we have reported that the N-terminal r...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-09, Vol.569, p.106-111
Hauptverfasser:	Shimakura, Kento, Sato, Kai, Mitsui, Shun, Ono, Suzuka, Otomo, Asako, Hadano, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	ALS2 Cellular distribution Intrinsically disordered region Oligomerization Phosphorylation
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