SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice

A metabolic imbalance between lipid synthesis and degradation can lead to hepatic lipid accumulation, a characteristic of patients with non-alcoholic fatty liver disease (NAFLD). Here, we report that high-fat-diet-induced sterol regulatory element-binding protein (SREBP)-1c, a key transcription fact...

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Veröffentlicht in:	Molecular cell 2021-09, Vol.81 (18), p.3820-3832.e7
Hauptverfasser:	Nguyen, Thuy T.P., Kim, Do-Young, Lee, Yu-Geon, Lee, Young-Seung, Truong, Xuan T., Lee, Jae-Ho, Song, Dae-Kyu, Kwon, Taeg Kyu, Park, So-Hyun, Jung, Chang Hwa, Moon, Changjong, Osborne, Timothy F., Im, Seung-Soon, Jeon, Tae-Il
Format:	Artikel
Sprache:	eng
Schlagworte:	autophagy hydrogen sulfide SREBP-1c steatosis sulfhydration ULK1
Online-Zugang:	Volltext
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