Hematopoietic stem cell transplantation reverses white matter injury measured by diffusion-tensor imaging (DTI) in sickle cell disease patients
Brain injury in sickle cell disease (SCD) comprises a wide spectrum of neurological damage. Neurocognitive deficits have been described even without established neurological lesions. DTI is a rapid, noninvasive, and non-contrast method that enables detection of normal-appearing white matter lesions...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2021-11, Vol.56 (11), p.2705-2713 |
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| creator | Costa, Thalita Cristina de Mello Chiari-Correia, Rodolfo Salmon, Carlos Ernesto G. Darrigo-Junior, Luiz Guilherme Grecco, Carlos Eduardo S. Pieroni, Fabiano Faria, Joana Teresa B. Stracieri, Ana Beatriz P. L. Dias, Juliana B. E. de Moraes, Daniela Aparecida Oliveira, Maria Carolina Guerino-Cunha, Renato Santos, Antônio Carlos Simões, Belinda P. |
| description | Brain injury in sickle cell disease (SCD) comprises a wide spectrum of neurological damage. Neurocognitive deficits have been described even without established neurological lesions. DTI is a rapid, noninvasive, and non-contrast method that enables detection of normal-appearing white matter lesions not detected by conventional magnetic resonance imaging (MRI). The aim of the study was to evaluate if stem cell transplantation can revert white matter lesions in patients with SCD. Twenty-eight SCD patients were evaluated with MRI and DTI before and after allogeneic hematopoietic stem cell transplantation (HSCT), compared with 26 healthy controls (HC). DTI metrics included fractional anisotropy (FA), mean diffusivity (MD), radial (RD), and axial (AD) diffusivity maps, global efficiency, path length, and clustering coefficients. Compared to HC, SCD patients had a lower FA (
p
= 0.0086) before HSCT. After HSCT, FA increased and was not different from healthy controls (
p
= 0.1769). Mean MD, RD, and AD decreased after HSCT (
p
= 0.0049;
p
= 0.0029;
p
= 0.0408, respectively). We confirm previous data of white matter lesions in SCD and present evidence that HSCT promotes recovery of brain injury with potential improvement of brain structural connectivity. |
| doi_str_mv | 10.1038/s41409-021-01365-z |
| format | Article |
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p
= 0.0086) before HSCT. After HSCT, FA increased and was not different from healthy controls (
p
= 0.1769). Mean MD, RD, and AD decreased after HSCT (
p
= 0.0049;
p
= 0.0029;
p
= 0.0408, respectively). We confirm previous data of white matter lesions in SCD and present evidence that HSCT promotes recovery of brain injury with potential improvement of brain structural connectivity.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/s41409-021-01365-z</identifier><identifier>PMID: 34234298</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/532/1542 ; 692/699/1541/13 ; Anemia, Sickle Cell - pathology ; Anemia, Sickle Cell - therapy ; Anisotropy ; Brain ; Brain Injuries - pathology ; Brain injury ; Care and treatment ; Cell Biology ; Clustering ; Cognition ; Diagnosis ; Diffusion Tensor Imaging - methods ; Diffusivity ; Evaluation ; Head injuries ; Hematology ; Hematopoietic Stem Cell Transplantation ; Hematopoietic stem cells ; Humans ; Internal Medicine ; Lesions ; Magnetic resonance imaging ; Medical imaging ; Medicine ; Medicine & Public Health ; Neural networks ; Neuroimaging ; Neurological diseases ; Public Health ; Sickle cell anemia ; Sickle cell disease ; Stem cell transplantation ; Stem Cells ; Substantia alba ; Tensors ; Transplantation ; Traumatic brain injury ; White Matter - diagnostic imaging ; White Matter - pathology</subject><ispartof>Bone marrow transplantation (Basingstoke), 2021-11, Vol.56 (11), p.2705-2713</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-8cdefc3db4cfc2b9a3f9d1289ee262937c7695fdf6c991c2f91b41b3d497b2d83</citedby><cites>FETCH-LOGICAL-c473t-8cdefc3db4cfc2b9a3f9d1289ee262937c7695fdf6c991c2f91b41b3d497b2d83</cites><orcidid>0000-0003-0691-2222 ; 0000-0002-9398-3338 ; 0000-0002-5502-4734 ; 0000-0001-6007-8908 ; 0000-0003-3936-0129</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41409-021-01365-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41409-021-01365-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34234298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costa, Thalita Cristina de Mello</creatorcontrib><creatorcontrib>Chiari-Correia, Rodolfo</creatorcontrib><creatorcontrib>Salmon, Carlos Ernesto G.</creatorcontrib><creatorcontrib>Darrigo-Junior, Luiz Guilherme</creatorcontrib><creatorcontrib>Grecco, Carlos Eduardo S.</creatorcontrib><creatorcontrib>Pieroni, Fabiano</creatorcontrib><creatorcontrib>Faria, Joana Teresa B.</creatorcontrib><creatorcontrib>Stracieri, Ana Beatriz P. L.</creatorcontrib><creatorcontrib>Dias, Juliana B. E.</creatorcontrib><creatorcontrib>de Moraes, Daniela Aparecida</creatorcontrib><creatorcontrib>Oliveira, Maria Carolina</creatorcontrib><creatorcontrib>Guerino-Cunha, Renato</creatorcontrib><creatorcontrib>Santos, Antônio Carlos</creatorcontrib><creatorcontrib>Simões, Belinda P.</creatorcontrib><title>Hematopoietic stem cell transplantation reverses white matter injury measured by diffusion-tensor imaging (DTI) in sickle cell disease patients</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>Brain injury in sickle cell disease (SCD) comprises a wide spectrum of neurological damage. Neurocognitive deficits have been described even without established neurological lesions. DTI is a rapid, noninvasive, and non-contrast method that enables detection of normal-appearing white matter lesions not detected by conventional magnetic resonance imaging (MRI). The aim of the study was to evaluate if stem cell transplantation can revert white matter lesions in patients with SCD. Twenty-eight SCD patients were evaluated with MRI and DTI before and after allogeneic hematopoietic stem cell transplantation (HSCT), compared with 26 healthy controls (HC). DTI metrics included fractional anisotropy (FA), mean diffusivity (MD), radial (RD), and axial (AD) diffusivity maps, global efficiency, path length, and clustering coefficients. Compared to HC, SCD patients had a lower FA (
p
= 0.0086) before HSCT. After HSCT, FA increased and was not different from healthy controls (
p
= 0.1769). Mean MD, RD, and AD decreased after HSCT (
p
= 0.0049;
p
= 0.0029;
p
= 0.0408, respectively). We confirm previous data of white matter lesions in SCD and present evidence that HSCT promotes recovery of brain injury with potential improvement of brain structural connectivity.</description><subject>631/532/1542</subject><subject>692/699/1541/13</subject><subject>Anemia, Sickle Cell - pathology</subject><subject>Anemia, Sickle Cell - therapy</subject><subject>Anisotropy</subject><subject>Brain</subject><subject>Brain Injuries - pathology</subject><subject>Brain injury</subject><subject>Care and treatment</subject><subject>Cell Biology</subject><subject>Clustering</subject><subject>Cognition</subject><subject>Diagnosis</subject><subject>Diffusion Tensor Imaging - methods</subject><subject>Diffusivity</subject><subject>Evaluation</subject><subject>Head injuries</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Neurological diseases</subject><subject>Public Health</subject><subject>Sickle cell anemia</subject><subject>Sickle cell disease</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Substantia alba</subject><subject>Tensors</subject><subject>Transplantation</subject><subject>Traumatic brain injury</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - pathology</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kltvFCEYhidGY9fqH_DCkJiYejGV0zBw2dRDmzTxpl5PZuBjl3UGVmA02z_hX5Z1qrXGGEgI8LzfAd6qek7wKcFMvkmccKxqTEmNCRNNffOgWhHeiropu4fVClMha8aEOqqepLTFmHCOm8fVEeO0TCVX1fcLmPocdsFBdhqlDBPSMI4ox96n3dj73GcXPIrwFWKChL5tXAZURBkicn47xz2aoE9zBIOGPTLO2jkVSZ3Bp1CYqV87v0Ynb68vXxcFSk5_HmFJY1wqWkC7kgV8Tk-rR7YfEzy7XY-rT-_fXZ9f1FcfP1yen13Vmrcs11IbsJqZgWur6aB6ZpUhVCoAKqhirW6FaqyxQitFNLWKDJwMzHDVDtRIdlydLHF3MXyZIeVuculQUe8hzKmjDVdCtrI5oC__Qrdhjr5UVyhFpOCY0Dtq3Y_QOW9DeUF9CNqdCUmwbIVoC3X6D6oMA5PTwYN15fye4NUfgg30Y96kMM6HP0n3QbqAOoaUIthuF8vLx31HcHewS7fYpSt26X7apbspohe3rc3DBOa35Jc_CsAWIJUrv4Z41_t_wv4A7ADMTA</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Costa, Thalita Cristina de Mello</creator><creator>Chiari-Correia, Rodolfo</creator><creator>Salmon, Carlos Ernesto G.</creator><creator>Darrigo-Junior, Luiz Guilherme</creator><creator>Grecco, Carlos Eduardo S.</creator><creator>Pieroni, Fabiano</creator><creator>Faria, Joana Teresa B.</creator><creator>Stracieri, Ana Beatriz P. 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E.</creator><creator>de Moraes, Daniela Aparecida</creator><creator>Oliveira, Maria Carolina</creator><creator>Guerino-Cunha, Renato</creator><creator>Santos, Antônio Carlos</creator><creator>Simões, Belinda P.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0691-2222</orcidid><orcidid>https://orcid.org/0000-0002-9398-3338</orcidid><orcidid>https://orcid.org/0000-0002-5502-4734</orcidid><orcidid>https://orcid.org/0000-0001-6007-8908</orcidid><orcidid>https://orcid.org/0000-0003-3936-0129</orcidid></search><sort><creationdate>20211101</creationdate><title>Hematopoietic stem cell transplantation reverses white matter injury measured by diffusion-tensor imaging (DTI) in sickle cell disease patients</title><author>Costa, Thalita Cristina de Mello ; Chiari-Correia, Rodolfo ; Salmon, Carlos Ernesto G. ; Darrigo-Junior, Luiz Guilherme ; Grecco, Carlos Eduardo S. ; Pieroni, Fabiano ; Faria, Joana Teresa B. ; Stracieri, Ana Beatriz P. L. ; Dias, Juliana B. E. ; de Moraes, Daniela Aparecida ; Oliveira, Maria Carolina ; Guerino-Cunha, Renato ; Santos, Antônio Carlos ; Simões, Belinda P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-8cdefc3db4cfc2b9a3f9d1289ee262937c7695fdf6c991c2f91b41b3d497b2d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/532/1542</topic><topic>692/699/1541/13</topic><topic>Anemia, Sickle Cell - pathology</topic><topic>Anemia, Sickle Cell - therapy</topic><topic>Anisotropy</topic><topic>Brain</topic><topic>Brain Injuries - pathology</topic><topic>Brain injury</topic><topic>Care and treatment</topic><topic>Cell Biology</topic><topic>Clustering</topic><topic>Cognition</topic><topic>Diagnosis</topic><topic>Diffusion Tensor Imaging - methods</topic><topic>Diffusivity</topic><topic>Evaluation</topic><topic>Head injuries</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lesions</topic><topic>Magnetic resonance imaging</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neural networks</topic><topic>Neuroimaging</topic><topic>Neurological diseases</topic><topic>Public Health</topic><topic>Sickle cell anemia</topic><topic>Sickle cell disease</topic><topic>Stem cell transplantation</topic><topic>Stem Cells</topic><topic>Substantia alba</topic><topic>Tensors</topic><topic>Transplantation</topic><topic>Traumatic brain injury</topic><topic>White Matter - diagnostic imaging</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costa, Thalita Cristina de Mello</creatorcontrib><creatorcontrib>Chiari-Correia, Rodolfo</creatorcontrib><creatorcontrib>Salmon, Carlos Ernesto G.</creatorcontrib><creatorcontrib>Darrigo-Junior, Luiz Guilherme</creatorcontrib><creatorcontrib>Grecco, Carlos Eduardo S.</creatorcontrib><creatorcontrib>Pieroni, Fabiano</creatorcontrib><creatorcontrib>Faria, Joana Teresa B.</creatorcontrib><creatorcontrib>Stracieri, Ana Beatriz P. L.</creatorcontrib><creatorcontrib>Dias, Juliana B. E.</creatorcontrib><creatorcontrib>de Moraes, Daniela Aparecida</creatorcontrib><creatorcontrib>Oliveira, Maria Carolina</creatorcontrib><creatorcontrib>Guerino-Cunha, Renato</creatorcontrib><creatorcontrib>Santos, Antônio Carlos</creatorcontrib><creatorcontrib>Simões, Belinda P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costa, Thalita Cristina de Mello</au><au>Chiari-Correia, Rodolfo</au><au>Salmon, Carlos Ernesto G.</au><au>Darrigo-Junior, Luiz Guilherme</au><au>Grecco, Carlos Eduardo S.</au><au>Pieroni, Fabiano</au><au>Faria, Joana Teresa B.</au><au>Stracieri, Ana Beatriz P. L.</au><au>Dias, Juliana B. E.</au><au>de Moraes, Daniela Aparecida</au><au>Oliveira, Maria Carolina</au><au>Guerino-Cunha, Renato</au><au>Santos, Antônio Carlos</au><au>Simões, Belinda P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hematopoietic stem cell transplantation reverses white matter injury measured by diffusion-tensor imaging (DTI) in sickle cell disease patients</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>56</volume><issue>11</issue><spage>2705</spage><epage>2713</epage><pages>2705-2713</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><abstract>Brain injury in sickle cell disease (SCD) comprises a wide spectrum of neurological damage. Neurocognitive deficits have been described even without established neurological lesions. DTI is a rapid, noninvasive, and non-contrast method that enables detection of normal-appearing white matter lesions not detected by conventional magnetic resonance imaging (MRI). The aim of the study was to evaluate if stem cell transplantation can revert white matter lesions in patients with SCD. Twenty-eight SCD patients were evaluated with MRI and DTI before and after allogeneic hematopoietic stem cell transplantation (HSCT), compared with 26 healthy controls (HC). DTI metrics included fractional anisotropy (FA), mean diffusivity (MD), radial (RD), and axial (AD) diffusivity maps, global efficiency, path length, and clustering coefficients. Compared to HC, SCD patients had a lower FA (
p
= 0.0086) before HSCT. After HSCT, FA increased and was not different from healthy controls (
p
= 0.1769). Mean MD, RD, and AD decreased after HSCT (
p
= 0.0049;
p
= 0.0029;
p
= 0.0408, respectively). We confirm previous data of white matter lesions in SCD and present evidence that HSCT promotes recovery of brain injury with potential improvement of brain structural connectivity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34234298</pmid><doi>10.1038/s41409-021-01365-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0691-2222</orcidid><orcidid>https://orcid.org/0000-0002-9398-3338</orcidid><orcidid>https://orcid.org/0000-0002-5502-4734</orcidid><orcidid>https://orcid.org/0000-0001-6007-8908</orcidid><orcidid>https://orcid.org/0000-0003-3936-0129</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2021-11, Vol.56 (11), p.2705-2713 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2549687858 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | 631/532/1542 692/699/1541/13 Anemia, Sickle Cell - pathology Anemia, Sickle Cell - therapy Anisotropy Brain Brain Injuries - pathology Brain injury Care and treatment Cell Biology Clustering Cognition Diagnosis Diffusion Tensor Imaging - methods Diffusivity Evaluation Head injuries Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Internal Medicine Lesions Magnetic resonance imaging Medical imaging Medicine Medicine & Public Health Neural networks Neuroimaging Neurological diseases Public Health Sickle cell anemia Sickle cell disease Stem cell transplantation Stem Cells Substantia alba Tensors Transplantation Traumatic brain injury White Matter - diagnostic imaging White Matter - pathology |
| title | Hematopoietic stem cell transplantation reverses white matter injury measured by diffusion-tensor imaging (DTI) in sickle cell disease patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T05%3A58%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hematopoietic%20stem%20cell%20transplantation%20reverses%20white%20matter%20injury%20measured%20by%20diffusion-tensor%20imaging%20(DTI)%20in%20sickle%20cell%20disease%20patients&rft.jtitle=Bone%20marrow%20transplantation%20(Basingstoke)&rft.au=Costa,%20Thalita%20Cristina%20de%20Mello&rft.date=2021-11-01&rft.volume=56&rft.issue=11&rft.spage=2705&rft.epage=2713&rft.pages=2705-2713&rft.issn=0268-3369&rft.eissn=1476-5365&rft_id=info:doi/10.1038/s41409-021-01365-z&rft_dat=%3Cgale_proqu%3EA681087667%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2591864012&rft_id=info:pmid/34234298&rft_galeid=A681087667&rfr_iscdi=true |