LincRNA-p21 Inhibits Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Epithelial Cells by Sponging miR-449a
Introduction: LincRNA-p21 is predicted to interact with miR-449a, which plays a protective role in cisplatin-induced acute kidney injury (CIA). Objective: This study aimed to analyze the involvement of lincRNA-p21 in breast cancer patients with CIA. Methods: Levels of lincRNA-p21 in plasma from CIA,...
Gespeichert in:
| Veröffentlicht in: | Kidney & blood pressure research 2021-08, Vol.46 (4), p.495-501 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 501 |
|---|---|
| container_issue | 4 |
| container_start_page | 495 |
| container_title | Kidney & blood pressure research |
| container_volume | 46 |
| creator | Li, Zhen Hou, Gang |
| description | Introduction: LincRNA-p21 is predicted to interact with miR-449a, which plays a protective role in cisplatin-induced acute kidney injury (CIA). Objective: This study aimed to analyze the involvement of lincRNA-p21 in breast cancer patients with CIA. Methods: Levels of lincRNA-p21 in plasma from CIA, triple negative breast cancer, and control groups were measured by performing RT-qPCR. The potential interaction between lincRNA-p21 and miR-449a was first predicted by RT-qPCR. The relationship between lincRNA-p21 and miR-449a was analyzed by overexpression experiment. Results: We found that lincRNA-p21 is downregulated in CIA. Dual luciferase activity assay showed that lincRNA-p21 and miR-449a can interact with each other, while overexpression of lincRNA-p21 and miR-449a failed to affect the expression of each other. In human renal proximal tubular epithelial cells (HRPTEpCs), cisplatin led to the upregulated miR-449a but downregulated lincRNA-p21. Interestingly, lincRNA-p21 overexpression led to reduced enhancing effects of miR-449a on the cisplatin-induced apoptosis of HRPTEpCs. Conclusion: Therefore, lincRNA-p21 is downregulated in CIA and may sponge miR-449a to inhibit cisplatin-induced apoptosis of HRPTEpCs. |
| doi_str_mv | 10.1159/000509229 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2548626406</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A673226923</galeid><doaj_id>oai_doaj_org_article_a3cc210145c04d879ef913096f619ecf</doaj_id><sourcerecordid>A673226923</sourcerecordid><originalsourceid>FETCH-LOGICAL-c530t-d45409a826de2ac2edd7f3400390b0ed0bbe202c58cd2c239fcd8b09910ba1343</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEoqVw4I6QJS5wSBl_JBsfl1VpV6wALeVsObaTeknsYCeI_vt6N8siIeSDR6PH77wznix7ieES44K_B4ACOCH8UXaOGaE5YEYfH2LIGfDyLHsW4-6AAXmanVFGcEUonGe_Ntap7edlPhCM1u7O1naMaGXj0MnRunzt9KSMRsvBD6OPNiLfoJuplw5tjZMd-hr8b9un4Haqp04GdDXY8c50NqVWpusiqu_Rt8G71roW9XabM8bl8-xJI7toXhzvi-z7x6vb1U2--XK9Xi03uSoojLlmRbIvK1JqQ6QiRutFQxkA5VCD0VDXhgBRRaU0UYTyRumqBs4x1BJTRi-y9ayrvdyJISSn4V54acUh4UMrZBit6oyQVCmC0-QKBUxXC24ajmkaXlNiblSTtN7OWkPwPycTR9HbqFKL0hk_RUEKVpWkZFAm9M0_6M5PIY1rT5WswGyx2Ju7nKlWpvrWNX4MUqWjTW-Vd6axKb8sF5SQkhOaHrybH6jgYwymOXWEQew3QZw2IbGvjxamujf6RP75-r8ef8jQmnACPn3YzhJi0PumX_2XOlZ5AKU7v4k</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2564514774</pqid></control><display><type>article</type><title>LincRNA-p21 Inhibits Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Epithelial Cells by Sponging miR-449a</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Karger Open Access</source><creator>Li, Zhen ; Hou, Gang</creator><creatorcontrib>Li, Zhen ; Hou, Gang</creatorcontrib><description>Introduction: LincRNA-p21 is predicted to interact with miR-449a, which plays a protective role in cisplatin-induced acute kidney injury (CIA). Objective: This study aimed to analyze the involvement of lincRNA-p21 in breast cancer patients with CIA. Methods: Levels of lincRNA-p21 in plasma from CIA, triple negative breast cancer, and control groups were measured by performing RT-qPCR. The potential interaction between lincRNA-p21 and miR-449a was first predicted by RT-qPCR. The relationship between lincRNA-p21 and miR-449a was analyzed by overexpression experiment. Results: We found that lincRNA-p21 is downregulated in CIA. Dual luciferase activity assay showed that lincRNA-p21 and miR-449a can interact with each other, while overexpression of lincRNA-p21 and miR-449a failed to affect the expression of each other. In human renal proximal tubular epithelial cells (HRPTEpCs), cisplatin led to the upregulated miR-449a but downregulated lincRNA-p21. Interestingly, lincRNA-p21 overexpression led to reduced enhancing effects of miR-449a on the cisplatin-induced apoptosis of HRPTEpCs. Conclusion: Therefore, lincRNA-p21 is downregulated in CIA and may sponge miR-449a to inhibit cisplatin-induced apoptosis of HRPTEpCs.</description><identifier>ISSN: 1420-4096</identifier><identifier>EISSN: 1423-0143</identifier><identifier>DOI: 10.1159/000509229</identifier><identifier>PMID: 34218230</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Acute Kidney Injury - chemically induced ; Acute Kidney Injury - genetics ; Adult ; Age ; Aged ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Apoptosis ; Apoptosis - drug effects ; Breast cancer ; Cancer ; Care and treatment ; Chemotherapy ; Cisplatin ; Cisplatin - adverse effects ; Cisplatin - therapeutic use ; cisplatin-induced acute kidney injury ; Complications and side effects ; Cyclin-dependent kinase inhibitor p21 ; Down-Regulation - drug effects ; Epithelial cells ; Epithelium ; Experiments ; Female ; Flow cytometry ; Gene expression ; Gene Expression Regulation, Neoplastic - drug effects ; Genetic aspects ; Humans ; Injury analysis ; Kidney failure ; Kidney Tubules, Proximal - cytology ; Kidney Tubules, Proximal - drug effects ; Kidneys ; lincrna-p21 ; MicroRNAs - genetics ; Middle Aged ; mir-449a ; Physiology ; Plasma ; renal proximal tubular epithelial cells ; Research Article ; Risk factors ; RNA, Long Noncoding - genetics ; Triple Negative Breast Neoplasms - drug therapy ; Triple Negative Breast Neoplasms - genetics ; Up-Regulation - drug effects</subject><ispartof>Kidney & blood pressure research, 2021-08, Vol.46 (4), p.495-501</ispartof><rights>2021 The Author(s). Published by S. Karger AG, Basel</rights><rights>2021 The Author(s). Published by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2021 S. Karger AG</rights><rights>2021 The Author(s). Published by S. Karger AG, Basel . This work is licensed under the Creative Commons Attribution – Non-Commercial – No Derivatives License https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-d45409a826de2ac2edd7f3400390b0ed0bbe202c58cd2c239fcd8b09910ba1343</citedby><cites>FETCH-LOGICAL-c530t-d45409a826de2ac2edd7f3400390b0ed0bbe202c58cd2c239fcd8b09910ba1343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,2096,27616,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34218230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Zhen</creatorcontrib><creatorcontrib>Hou, Gang</creatorcontrib><title>LincRNA-p21 Inhibits Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Epithelial Cells by Sponging miR-449a</title><title>Kidney & blood pressure research</title><addtitle>Kidney Blood Press Res</addtitle><description>Introduction: LincRNA-p21 is predicted to interact with miR-449a, which plays a protective role in cisplatin-induced acute kidney injury (CIA). Objective: This study aimed to analyze the involvement of lincRNA-p21 in breast cancer patients with CIA. Methods: Levels of lincRNA-p21 in plasma from CIA, triple negative breast cancer, and control groups were measured by performing RT-qPCR. The potential interaction between lincRNA-p21 and miR-449a was first predicted by RT-qPCR. The relationship between lincRNA-p21 and miR-449a was analyzed by overexpression experiment. Results: We found that lincRNA-p21 is downregulated in CIA. Dual luciferase activity assay showed that lincRNA-p21 and miR-449a can interact with each other, while overexpression of lincRNA-p21 and miR-449a failed to affect the expression of each other. In human renal proximal tubular epithelial cells (HRPTEpCs), cisplatin led to the upregulated miR-449a but downregulated lincRNA-p21. Interestingly, lincRNA-p21 overexpression led to reduced enhancing effects of miR-449a on the cisplatin-induced apoptosis of HRPTEpCs. Conclusion: Therefore, lincRNA-p21 is downregulated in CIA and may sponge miR-449a to inhibit cisplatin-induced apoptosis of HRPTEpCs.</description><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - genetics</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Cisplatin - adverse effects</subject><subject>Cisplatin - therapeutic use</subject><subject>cisplatin-induced acute kidney injury</subject><subject>Complications and side effects</subject><subject>Cyclin-dependent kinase inhibitor p21</subject><subject>Down-Regulation - drug effects</subject><subject>Epithelial cells</subject><subject>Epithelium</subject><subject>Experiments</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Injury analysis</subject><subject>Kidney failure</subject><subject>Kidney Tubules, Proximal - cytology</subject><subject>Kidney Tubules, Proximal - drug effects</subject><subject>Kidneys</subject><subject>lincrna-p21</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>mir-449a</subject><subject>Physiology</subject><subject>Plasma</subject><subject>renal proximal tubular epithelial cells</subject><subject>Research Article</subject><subject>Risk factors</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Triple Negative Breast Neoplasms - drug therapy</subject><subject>Triple Negative Breast Neoplasms - genetics</subject><subject>Up-Regulation - drug effects</subject><issn>1420-4096</issn><issn>1423-0143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEoqVw4I6QJS5wSBl_JBsfl1VpV6wALeVsObaTeknsYCeI_vt6N8siIeSDR6PH77wznix7ieES44K_B4ACOCH8UXaOGaE5YEYfH2LIGfDyLHsW4-6AAXmanVFGcEUonGe_Ntap7edlPhCM1u7O1naMaGXj0MnRunzt9KSMRsvBD6OPNiLfoJuplw5tjZMd-hr8b9un4Haqp04GdDXY8c50NqVWpusiqu_Rt8G71roW9XabM8bl8-xJI7toXhzvi-z7x6vb1U2--XK9Xi03uSoojLlmRbIvK1JqQ6QiRutFQxkA5VCD0VDXhgBRRaU0UYTyRumqBs4x1BJTRi-y9ayrvdyJISSn4V54acUh4UMrZBit6oyQVCmC0-QKBUxXC24ajmkaXlNiblSTtN7OWkPwPycTR9HbqFKL0hk_RUEKVpWkZFAm9M0_6M5PIY1rT5WswGyx2Ju7nKlWpvrWNX4MUqWjTW-Vd6axKb8sF5SQkhOaHrybH6jgYwymOXWEQew3QZw2IbGvjxamujf6RP75-r8ef8jQmnACPn3YzhJi0PumX_2XOlZ5AKU7v4k</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Li, Zhen</creator><creator>Hou, Gang</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20210801</creationdate><title>LincRNA-p21 Inhibits Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Epithelial Cells by Sponging miR-449a</title><author>Li, Zhen ; Hou, Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-d45409a826de2ac2edd7f3400390b0ed0bbe202c58cd2c239fcd8b09910ba1343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute Kidney Injury - chemically induced</topic><topic>Acute Kidney Injury - genetics</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>Cisplatin - adverse effects</topic><topic>Cisplatin - therapeutic use</topic><topic>cisplatin-induced acute kidney injury</topic><topic>Complications and side effects</topic><topic>Cyclin-dependent kinase inhibitor p21</topic><topic>Down-Regulation - drug effects</topic><topic>Epithelial cells</topic><topic>Epithelium</topic><topic>Experiments</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Injury analysis</topic><topic>Kidney failure</topic><topic>Kidney Tubules, Proximal - cytology</topic><topic>Kidney Tubules, Proximal - drug effects</topic><topic>Kidneys</topic><topic>lincrna-p21</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>mir-449a</topic><topic>Physiology</topic><topic>Plasma</topic><topic>renal proximal tubular epithelial cells</topic><topic>Research Article</topic><topic>Risk factors</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Triple Negative Breast Neoplasms - drug therapy</topic><topic>Triple Negative Breast Neoplasms - genetics</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhen</creatorcontrib><creatorcontrib>Hou, Gang</creatorcontrib><collection>Karger Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Kidney & blood pressure research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhen</au><au>Hou, Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LincRNA-p21 Inhibits Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Epithelial Cells by Sponging miR-449a</atitle><jtitle>Kidney & blood pressure research</jtitle><addtitle>Kidney Blood Press Res</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>46</volume><issue>4</issue><spage>495</spage><epage>501</epage><pages>495-501</pages><issn>1420-4096</issn><eissn>1423-0143</eissn><abstract>Introduction: LincRNA-p21 is predicted to interact with miR-449a, which plays a protective role in cisplatin-induced acute kidney injury (CIA). Objective: This study aimed to analyze the involvement of lincRNA-p21 in breast cancer patients with CIA. Methods: Levels of lincRNA-p21 in plasma from CIA, triple negative breast cancer, and control groups were measured by performing RT-qPCR. The potential interaction between lincRNA-p21 and miR-449a was first predicted by RT-qPCR. The relationship between lincRNA-p21 and miR-449a was analyzed by overexpression experiment. Results: We found that lincRNA-p21 is downregulated in CIA. Dual luciferase activity assay showed that lincRNA-p21 and miR-449a can interact with each other, while overexpression of lincRNA-p21 and miR-449a failed to affect the expression of each other. In human renal proximal tubular epithelial cells (HRPTEpCs), cisplatin led to the upregulated miR-449a but downregulated lincRNA-p21. Interestingly, lincRNA-p21 overexpression led to reduced enhancing effects of miR-449a on the cisplatin-induced apoptosis of HRPTEpCs. Conclusion: Therefore, lincRNA-p21 is downregulated in CIA and may sponge miR-449a to inhibit cisplatin-induced apoptosis of HRPTEpCs.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>34218230</pmid><doi>10.1159/000509229</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1420-4096 |
| ispartof | Kidney & blood pressure research, 2021-08, Vol.46 (4), p.495-501 |
| issn | 1420-4096 1423-0143 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2548626406 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Karger Open Access |
| subjects | Acute Kidney Injury - chemically induced Acute Kidney Injury - genetics Adult Age Aged Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Breast cancer Cancer Care and treatment Chemotherapy Cisplatin Cisplatin - adverse effects Cisplatin - therapeutic use cisplatin-induced acute kidney injury Complications and side effects Cyclin-dependent kinase inhibitor p21 Down-Regulation - drug effects Epithelial cells Epithelium Experiments Female Flow cytometry Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Humans Injury analysis Kidney failure Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - drug effects Kidneys lincrna-p21 MicroRNAs - genetics Middle Aged mir-449a Physiology Plasma renal proximal tubular epithelial cells Research Article Risk factors RNA, Long Noncoding - genetics Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Up-Regulation - drug effects |
| title | LincRNA-p21 Inhibits Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Epithelial Cells by Sponging miR-449a |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T01%3A47%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=LincRNA-p21%20Inhibits%20Cisplatin-Induced%20Apoptosis%20of%20Human%20Renal%20Proximal%20Tubular%20Epithelial%20Cells%20by%20Sponging%20miR-449a&rft.jtitle=Kidney%20&%20blood%20pressure%20research&rft.au=Li,%20Zhen&rft.date=2021-08-01&rft.volume=46&rft.issue=4&rft.spage=495&rft.epage=501&rft.pages=495-501&rft.issn=1420-4096&rft.eissn=1423-0143&rft_id=info:doi/10.1159/000509229&rft_dat=%3Cgale_proqu%3EA673226923%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2564514774&rft_id=info:pmid/34218230&rft_galeid=A673226923&rft_doaj_id=oai_doaj_org_article_a3cc210145c04d879ef913096f619ecf&rfr_iscdi=true |