Medical X‐band linear accelerator for high‐precision radiotherapy

Purpose Recently, high‐precision radiotherapy systems have been developed by integrating computerized tomography or magnetic resonance imaging to enhance the precision of radiotherapy. For integration with additional imaging systems in a limited space, miniaturization and weight reduction of the lin...

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Veröffentlicht in:Medical physics (Lancaster) 2021-09, Vol.48 (9), p.5327-5342
Hauptverfasser: Lee, Yong‐Seok, Kim, Sanghoon, Kim, Geun‐Ju, Lee, Jeong‐Hun, Kim, Insoo S., Kim, Jung‐Il, Shin, Ki Young, Seol, Yunji, Oh, Taegeon, An, Na‐Young, Lee, Jaehyeon, Hwang, Jinho, Oh, Youngah, Kang, Young‐Nam
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container_issue 9
container_start_page 5327
container_title Medical physics (Lancaster)
container_volume 48
creator Lee, Yong‐Seok
Kim, Sanghoon
Kim, Geun‐Ju
Lee, Jeong‐Hun
Kim, Insoo S.
Kim, Jung‐Il
Shin, Ki Young
Seol, Yunji
Oh, Taegeon
An, Na‐Young
Lee, Jaehyeon
Hwang, Jinho
Oh, Youngah
Kang, Young‐Nam
description Purpose Recently, high‐precision radiotherapy systems have been developed by integrating computerized tomography or magnetic resonance imaging to enhance the precision of radiotherapy. For integration with additional imaging systems in a limited space, miniaturization and weight reduction of the linear accelerator (linac) system have become important. The aim of this work is to develop a compact medical linac based on 9.3 GHz X‐band RF technology instead of the S‐band RF technology typically used in the radiotherapy field. Methods The accelerating tube was designed by 3D finite‐difference time‐domain and particle‐in‐cell simulations because the frequency variation resulting from the structural parameters and processing errors is relatively sensitive to the operating performance of the X‐band linac. Through the 3D simulation of the electric field distribution and beam dynamics process, we designed an accelerating tube to efficiently accelerate the electron beam and used a magnetron as the RF source to miniaturize the entire linac. In addition, a side‐coupled structure was adopted to design a compact linac to reduce the RF power loss. To verify the performance of the linac, we developed a beam diagnostic system to analyze the electron beam characteristics and a quality assurance (QA) experimental environment including 3D lateral water phantoms to analyze the primary performance parameters (energy, dose rate, flatness, symmetry, and penumbra) The QA process was based on the standard protocols AAPM TG‐51, 106, 142 and IAEA TRS‐398. Results The X‐band linac has high shunt impedance and electric field strength. Therefore, even though the length of the accelerating tube is 37 cm, the linac could accelerate an electron beam to more than 6 MeV and produce a beam current of more than 90 mA. The transmission ratio is measured to be approximately 30% ~ 40% when the electron gun operates in the constant emission region. The percent depth dose ratio at the measured depths of 10 and 20 cm was approximately 0.572, so we verified that the photon beam energy was matched to approximately 6 MV. The maximum dose rate was measured as 820 cGy/min when the source‐to‐skin distance was 80 cm. The symmetry was smaller than the QA standard and the flatness had a higher than standard value due to the flattening filter‐free beam characteristics. In the case of the penumbra, it was not sufficiently steep compared to commercial equipment, but it could be compensated by improving addition
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For integration with additional imaging systems in a limited space, miniaturization and weight reduction of the linear accelerator (linac) system have become important. The aim of this work is to develop a compact medical linac based on 9.3 GHz X‐band RF technology instead of the S‐band RF technology typically used in the radiotherapy field. Methods The accelerating tube was designed by 3D finite‐difference time‐domain and particle‐in‐cell simulations because the frequency variation resulting from the structural parameters and processing errors is relatively sensitive to the operating performance of the X‐band linac. Through the 3D simulation of the electric field distribution and beam dynamics process, we designed an accelerating tube to efficiently accelerate the electron beam and used a magnetron as the RF source to miniaturize the entire linac. In addition, a side‐coupled structure was adopted to design a compact linac to reduce the RF power loss. To verify the performance of the linac, we developed a beam diagnostic system to analyze the electron beam characteristics and a quality assurance (QA) experimental environment including 3D lateral water phantoms to analyze the primary performance parameters (energy, dose rate, flatness, symmetry, and penumbra) The QA process was based on the standard protocols AAPM TG‐51, 106, 142 and IAEA TRS‐398. Results The X‐band linac has high shunt impedance and electric field strength. Therefore, even though the length of the accelerating tube is 37 cm, the linac could accelerate an electron beam to more than 6 MeV and produce a beam current of more than 90 mA. The transmission ratio is measured to be approximately 30% ~ 40% when the electron gun operates in the constant emission region. The percent depth dose ratio at the measured depths of 10 and 20 cm was approximately 0.572, so we verified that the photon beam energy was matched to approximately 6 MV. The maximum dose rate was measured as 820 cGy/min when the source‐to‐skin distance was 80 cm. The symmetry was smaller than the QA standard and the flatness had a higher than standard value due to the flattening filter‐free beam characteristics. In the case of the penumbra, it was not sufficiently steep compared to commercial equipment, but it could be compensated by improving additional devices such as multileaf collimator and jaw. Conclusions A 9.3 GHz X‐band medical linac was developed for high‐precision radiotherapy. Since a more precise design and machining process are required for X‐band RF technology, this linac was developed by performing a 3D simulation and ultraprecision machining. The X‐band linac has a short length and a compact volume, but it can generate a validated therapeutic beam. Therefore, it has more flexibility to be coupled with imaging systems such as CT or MRI and can reduce the bore size of the gantry. In addition, the weight reduction can improve the mechanical stiffness of the unit and reduce the mechanical load.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1002/mp.15077</identifier><identifier>PMID: 34224166</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>high‐precision radiotherapy ; Life Sciences &amp; Biomedicine ; linear accelerator ; Radiology, Nuclear Medicine &amp; Medical Imaging ; Science &amp; Technology ; X‐band RF technology ; X‐ray production</subject><ispartof>Medical physics (Lancaster), 2021-09, Vol.48 (9), p.5327-5342</ispartof><rights>2021 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>6</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000678224800001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3327-bcdb9a0d44ab7b019da714afcbd8f9c9af20df3b59a3dd8f830058600d6633f73</citedby><cites>FETCH-LOGICAL-c3327-bcdb9a0d44ab7b019da714afcbd8f9c9af20df3b59a3dd8f830058600d6633f73</cites><orcidid>0000-0003-4927-9746 ; 0000-0002-0586-4989</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmp.15077$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmp.15077$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,39267,45583,45584</link.rule.ids></links><search><creatorcontrib>Lee, Yong‐Seok</creatorcontrib><creatorcontrib>Kim, Sanghoon</creatorcontrib><creatorcontrib>Kim, Geun‐Ju</creatorcontrib><creatorcontrib>Lee, Jeong‐Hun</creatorcontrib><creatorcontrib>Kim, Insoo S.</creatorcontrib><creatorcontrib>Kim, Jung‐Il</creatorcontrib><creatorcontrib>Shin, Ki Young</creatorcontrib><creatorcontrib>Seol, Yunji</creatorcontrib><creatorcontrib>Oh, Taegeon</creatorcontrib><creatorcontrib>An, Na‐Young</creatorcontrib><creatorcontrib>Lee, Jaehyeon</creatorcontrib><creatorcontrib>Hwang, Jinho</creatorcontrib><creatorcontrib>Oh, Youngah</creatorcontrib><creatorcontrib>Kang, Young‐Nam</creatorcontrib><title>Medical X‐band linear accelerator for high‐precision radiotherapy</title><title>Medical physics (Lancaster)</title><addtitle>MED PHYS</addtitle><description>Purpose Recently, high‐precision radiotherapy systems have been developed by integrating computerized tomography or magnetic resonance imaging to enhance the precision of radiotherapy. For integration with additional imaging systems in a limited space, miniaturization and weight reduction of the linear accelerator (linac) system have become important. The aim of this work is to develop a compact medical linac based on 9.3 GHz X‐band RF technology instead of the S‐band RF technology typically used in the radiotherapy field. Methods The accelerating tube was designed by 3D finite‐difference time‐domain and particle‐in‐cell simulations because the frequency variation resulting from the structural parameters and processing errors is relatively sensitive to the operating performance of the X‐band linac. Through the 3D simulation of the electric field distribution and beam dynamics process, we designed an accelerating tube to efficiently accelerate the electron beam and used a magnetron as the RF source to miniaturize the entire linac. In addition, a side‐coupled structure was adopted to design a compact linac to reduce the RF power loss. To verify the performance of the linac, we developed a beam diagnostic system to analyze the electron beam characteristics and a quality assurance (QA) experimental environment including 3D lateral water phantoms to analyze the primary performance parameters (energy, dose rate, flatness, symmetry, and penumbra) The QA process was based on the standard protocols AAPM TG‐51, 106, 142 and IAEA TRS‐398. Results The X‐band linac has high shunt impedance and electric field strength. Therefore, even though the length of the accelerating tube is 37 cm, the linac could accelerate an electron beam to more than 6 MeV and produce a beam current of more than 90 mA. The transmission ratio is measured to be approximately 30% ~ 40% when the electron gun operates in the constant emission region. The percent depth dose ratio at the measured depths of 10 and 20 cm was approximately 0.572, so we verified that the photon beam energy was matched to approximately 6 MV. The maximum dose rate was measured as 820 cGy/min when the source‐to‐skin distance was 80 cm. The symmetry was smaller than the QA standard and the flatness had a higher than standard value due to the flattening filter‐free beam characteristics. In the case of the penumbra, it was not sufficiently steep compared to commercial equipment, but it could be compensated by improving additional devices such as multileaf collimator and jaw. Conclusions A 9.3 GHz X‐band medical linac was developed for high‐precision radiotherapy. Since a more precise design and machining process are required for X‐band RF technology, this linac was developed by performing a 3D simulation and ultraprecision machining. The X‐band linac has a short length and a compact volume, but it can generate a validated therapeutic beam. Therefore, it has more flexibility to be coupled with imaging systems such as CT or MRI and can reduce the bore size of the gantry. In addition, the weight reduction can improve the mechanical stiffness of the unit and reduce the mechanical load.</description><subject>high‐precision radiotherapy</subject><subject>Life Sciences &amp; Biomedicine</subject><subject>linear accelerator</subject><subject>Radiology, Nuclear Medicine &amp; Medical Imaging</subject><subject>Science &amp; Technology</subject><subject>X‐band RF technology</subject><subject>X‐ray production</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkM1KAzEQx4MotlbBR9ijIFtnk-xmc5SlfkCLHhS8Ldl82Mh-mWyR3nwEn9EnMbVFT4KHYYbhN8OfH0KnCUwTAHzR9NMkBcb20BhTRmKKge-jMQCnMaaQjtCR9y8AkJEUDtGIUIxpkmVjNFtoZaWoo6fP949KtCqqbauFi4SUutZODJ2LTKilfV4GpHdaWm-7NnJC2W5YBqRfH6MDI2qvT3Z9gh6vZg_FTTy_u74tLuexJASzuJKq4gIUpaJiFSRcCZZQYWSlcsMlFwaDMqRKuSAqrHICkOYZgMoyQgwjE3S2_du77nWl_VA21oectWh1t_IlTmnAGQX-i0rXee-0KXtnG-HWZQLlRlrZ9OW3tICeb9E3XXXGS6tbqX_wjTWWB195mCAJdP5_urCDGIKtolu1QziNd6e21us_A5WL-22wL26Zjgo</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Lee, Yong‐Seok</creator><creator>Kim, Sanghoon</creator><creator>Kim, Geun‐Ju</creator><creator>Lee, Jeong‐Hun</creator><creator>Kim, Insoo S.</creator><creator>Kim, Jung‐Il</creator><creator>Shin, Ki Young</creator><creator>Seol, Yunji</creator><creator>Oh, Taegeon</creator><creator>An, Na‐Young</creator><creator>Lee, Jaehyeon</creator><creator>Hwang, Jinho</creator><creator>Oh, Youngah</creator><creator>Kang, Young‐Nam</creator><general>Wiley</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4927-9746</orcidid><orcidid>https://orcid.org/0000-0002-0586-4989</orcidid></search><sort><creationdate>202109</creationdate><title>Medical X‐band linear accelerator for high‐precision radiotherapy</title><author>Lee, Yong‐Seok ; Kim, Sanghoon ; Kim, Geun‐Ju ; Lee, Jeong‐Hun ; Kim, Insoo S. ; Kim, Jung‐Il ; Shin, Ki Young ; Seol, Yunji ; Oh, Taegeon ; An, Na‐Young ; Lee, Jaehyeon ; Hwang, Jinho ; Oh, Youngah ; Kang, Young‐Nam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3327-bcdb9a0d44ab7b019da714afcbd8f9c9af20df3b59a3dd8f830058600d6633f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>high‐precision radiotherapy</topic><topic>Life Sciences &amp; Biomedicine</topic><topic>linear accelerator</topic><topic>Radiology, Nuclear Medicine &amp; Medical Imaging</topic><topic>Science &amp; Technology</topic><topic>X‐band RF technology</topic><topic>X‐ray production</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Yong‐Seok</creatorcontrib><creatorcontrib>Kim, Sanghoon</creatorcontrib><creatorcontrib>Kim, Geun‐Ju</creatorcontrib><creatorcontrib>Lee, Jeong‐Hun</creatorcontrib><creatorcontrib>Kim, Insoo S.</creatorcontrib><creatorcontrib>Kim, Jung‐Il</creatorcontrib><creatorcontrib>Shin, Ki Young</creatorcontrib><creatorcontrib>Seol, Yunji</creatorcontrib><creatorcontrib>Oh, Taegeon</creatorcontrib><creatorcontrib>An, Na‐Young</creatorcontrib><creatorcontrib>Lee, Jaehyeon</creatorcontrib><creatorcontrib>Hwang, Jinho</creatorcontrib><creatorcontrib>Oh, Youngah</creatorcontrib><creatorcontrib>Kang, Young‐Nam</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Yong‐Seok</au><au>Kim, Sanghoon</au><au>Kim, Geun‐Ju</au><au>Lee, Jeong‐Hun</au><au>Kim, Insoo S.</au><au>Kim, Jung‐Il</au><au>Shin, Ki Young</au><au>Seol, Yunji</au><au>Oh, Taegeon</au><au>An, Na‐Young</au><au>Lee, Jaehyeon</au><au>Hwang, Jinho</au><au>Oh, Youngah</au><au>Kang, Young‐Nam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medical X‐band linear accelerator for high‐precision radiotherapy</atitle><jtitle>Medical physics (Lancaster)</jtitle><stitle>MED PHYS</stitle><date>2021-09</date><risdate>2021</risdate><volume>48</volume><issue>9</issue><spage>5327</spage><epage>5342</epage><pages>5327-5342</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><abstract>Purpose Recently, high‐precision radiotherapy systems have been developed by integrating computerized tomography or magnetic resonance imaging to enhance the precision of radiotherapy. For integration with additional imaging systems in a limited space, miniaturization and weight reduction of the linear accelerator (linac) system have become important. The aim of this work is to develop a compact medical linac based on 9.3 GHz X‐band RF technology instead of the S‐band RF technology typically used in the radiotherapy field. Methods The accelerating tube was designed by 3D finite‐difference time‐domain and particle‐in‐cell simulations because the frequency variation resulting from the structural parameters and processing errors is relatively sensitive to the operating performance of the X‐band linac. Through the 3D simulation of the electric field distribution and beam dynamics process, we designed an accelerating tube to efficiently accelerate the electron beam and used a magnetron as the RF source to miniaturize the entire linac. In addition, a side‐coupled structure was adopted to design a compact linac to reduce the RF power loss. To verify the performance of the linac, we developed a beam diagnostic system to analyze the electron beam characteristics and a quality assurance (QA) experimental environment including 3D lateral water phantoms to analyze the primary performance parameters (energy, dose rate, flatness, symmetry, and penumbra) The QA process was based on the standard protocols AAPM TG‐51, 106, 142 and IAEA TRS‐398. Results The X‐band linac has high shunt impedance and electric field strength. Therefore, even though the length of the accelerating tube is 37 cm, the linac could accelerate an electron beam to more than 6 MeV and produce a beam current of more than 90 mA. The transmission ratio is measured to be approximately 30% ~ 40% when the electron gun operates in the constant emission region. The percent depth dose ratio at the measured depths of 10 and 20 cm was approximately 0.572, so we verified that the photon beam energy was matched to approximately 6 MV. The maximum dose rate was measured as 820 cGy/min when the source‐to‐skin distance was 80 cm. The symmetry was smaller than the QA standard and the flatness had a higher than standard value due to the flattening filter‐free beam characteristics. In the case of the penumbra, it was not sufficiently steep compared to commercial equipment, but it could be compensated by improving additional devices such as multileaf collimator and jaw. Conclusions A 9.3 GHz X‐band medical linac was developed for high‐precision radiotherapy. Since a more precise design and machining process are required for X‐band RF technology, this linac was developed by performing a 3D simulation and ultraprecision machining. The X‐band linac has a short length and a compact volume, but it can generate a validated therapeutic beam. Therefore, it has more flexibility to be coupled with imaging systems such as CT or MRI and can reduce the bore size of the gantry. In addition, the weight reduction can improve the mechanical stiffness of the unit and reduce the mechanical load.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>34224166</pmid><doi>10.1002/mp.15077</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-4927-9746</orcidid><orcidid>https://orcid.org/0000-0002-0586-4989</orcidid><oa>free_for_read</oa></addata></record>
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subjects high‐precision radiotherapy
Life Sciences & Biomedicine
linear accelerator
Radiology, Nuclear Medicine & Medical Imaging
Science & Technology
X‐band RF technology
X‐ray production
title Medical X‐band linear accelerator for high‐precision radiotherapy
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