Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke
Gender-specific differences were found in serum uric acid (SUA) levels and the risk of isolated distal deep vein thrombosis (IDDVT). This study aimed to explore the association among gender, SUA, and IDDVT in stroke patients. Finally, 3404 patients were recruited and divided into two groups: IDDVT (...
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| Veröffentlicht in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-08, Vol.31 (9), p.2700-2706 |
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| creator | Ren, Wenwei Huang, Qiqi Fan, Kaili Hu, Jingjie Cheng, Qianqian Xu, Minjie Xu, Ruoting Liu, Yuntao Wang, Liping Chen, Siyan Zhang, Wanli Zhu, Zhenguo Wu, Chunxue Xue, Langlang Dai, Yanman Yan, Feifan Huang, Guiqian He, Jincai |
| description | Gender-specific differences were found in serum uric acid (SUA) levels and the risk of isolated distal deep vein thrombosis (IDDVT). This study aimed to explore the association among gender, SUA, and IDDVT in stroke patients.
Finally, 3404 patients were recruited and divided into two groups: IDDVT (n = 1233) and Non-IDDVT (n = 2171) groups. Propensity score matching (PSM) was conducted to match the patients. Binary logistic regression was adopted to explore the association between SUA and IDDVT, with the SUA divided into quartiles. After PSM, 975 patients were included in each group. Non-IDDVT group had a larger proportion of male than IDDVT group (64.9% vs. 52.7%, p |
| doi_str_mv | 10.1016/j.numecd.2021.05.032 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2548602781</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0939475321002556</els_id><sourcerecordid>2548602781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c339t-73fd5fc91c51efb9eb650927621dede3ff3186debb76bbdb5879d93f1dad90cd3</originalsourceid><addsrcrecordid>eNp9kL1OwzAYRS0EEuXnDRg8siTYcZ3UCxKq-JMqsdDZsv19oS5pHGyXqm9PSpmZ7nLPle4h5IazkjNe363LfrtBB2XFKl4yWTJRnZAJl4oVoqnUKZkwJVQxbaQ4JxcprRkTDRPTCVkvo3fUOA906MwegRoaQ4fU9zSvkJqUgvMm-9BTi3mH2NMP7AEjNT1QQBzoN_6WY9jYkHw6oMNIYJ8T3fm8oinH8IlX5Kw1XcLrv7wky6fH9_lLsXh7fp0_LAonhMpFI1qQrVPcSY6tVWhryVTV1BUHBBRtK_isBrS2qa0FK2eNAiVaDgYUcyAuye1xd4jha4sp641PDrvO9Bi2SVdyOqtZ1cz4WJ0eqy6GlCK2eoh-Y-Jec6YPavVaH9Xqg1rNpB7Vjtj9EcPxxrfHqJMb7zoEH9FlDcH_P_ADY5qGdw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2548602781</pqid></control><display><type>article</type><title>Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Ren, Wenwei ; Huang, Qiqi ; Fan, Kaili ; Hu, Jingjie ; Cheng, Qianqian ; Xu, Minjie ; Xu, Ruoting ; Liu, Yuntao ; Wang, Liping ; Chen, Siyan ; Zhang, Wanli ; Zhu, Zhenguo ; Wu, Chunxue ; Xue, Langlang ; Dai, Yanman ; Yan, Feifan ; Huang, Guiqian ; He, Jincai</creator><creatorcontrib>Ren, Wenwei ; Huang, Qiqi ; Fan, Kaili ; Hu, Jingjie ; Cheng, Qianqian ; Xu, Minjie ; Xu, Ruoting ; Liu, Yuntao ; Wang, Liping ; Chen, Siyan ; Zhang, Wanli ; Zhu, Zhenguo ; Wu, Chunxue ; Xue, Langlang ; Dai, Yanman ; Yan, Feifan ; Huang, Guiqian ; He, Jincai</creatorcontrib><description>Gender-specific differences were found in serum uric acid (SUA) levels and the risk of isolated distal deep vein thrombosis (IDDVT). This study aimed to explore the association among gender, SUA, and IDDVT in stroke patients.
Finally, 3404 patients were recruited and divided into two groups: IDDVT (n = 1233) and Non-IDDVT (n = 2171) groups. Propensity score matching (PSM) was conducted to match the patients. Binary logistic regression was adopted to explore the association between SUA and IDDVT, with the SUA divided into quartiles. After PSM, 975 patients were included in each group. Non-IDDVT group had a larger proportion of male than IDDVT group (64.9% vs. 52.7%, p < 0.001). Moreover, males showed higher SUA levels than females (316.7 ± 102.1 vs. 261.8 ± 94.0 μmol/L, t = 12.1, p < 0.001). The highest quartile of SUA (≥346 μmol/L) showed a lower risk of IDDVT (OR = 0.629, p = 0.001), while the lowest quartile (≤225 μmol/L) showed a higher risk of IDDVT (OR = 1.361, p = 0.022).
In patients with stroke, SUA played a protective role in IDDVT. Females had a higher risk of IDDVT, which may be owing to the lower SUA levels than males. In clinical practice, more attention should be paid to the risk of IDDVT in females, especially those with lower SUA levels.
•Female had lower uric acid levels and higher risk of IDDVT than male.•There was a U-shaped relationship between uric acid and risk of IDDVT.•Uric acid played a role in the relationship between gender and IDDVT.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2021.05.032</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Deep vein thrombosis ; Gender ; Uric acid</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2021-08, Vol.31 (9), p.2700-2706</ispartof><rights>2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-73fd5fc91c51efb9eb650927621dede3ff3186debb76bbdb5879d93f1dad90cd3</citedby><cites>FETCH-LOGICAL-c339t-73fd5fc91c51efb9eb650927621dede3ff3186debb76bbdb5879d93f1dad90cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939475321002556$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids></links><search><creatorcontrib>Ren, Wenwei</creatorcontrib><creatorcontrib>Huang, Qiqi</creatorcontrib><creatorcontrib>Fan, Kaili</creatorcontrib><creatorcontrib>Hu, Jingjie</creatorcontrib><creatorcontrib>Cheng, Qianqian</creatorcontrib><creatorcontrib>Xu, Minjie</creatorcontrib><creatorcontrib>Xu, Ruoting</creatorcontrib><creatorcontrib>Liu, Yuntao</creatorcontrib><creatorcontrib>Wang, Liping</creatorcontrib><creatorcontrib>Chen, Siyan</creatorcontrib><creatorcontrib>Zhang, Wanli</creatorcontrib><creatorcontrib>Zhu, Zhenguo</creatorcontrib><creatorcontrib>Wu, Chunxue</creatorcontrib><creatorcontrib>Xue, Langlang</creatorcontrib><creatorcontrib>Dai, Yanman</creatorcontrib><creatorcontrib>Yan, Feifan</creatorcontrib><creatorcontrib>Huang, Guiqian</creatorcontrib><creatorcontrib>He, Jincai</creatorcontrib><title>Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke</title><title>Nutrition, metabolism, and cardiovascular diseases</title><description>Gender-specific differences were found in serum uric acid (SUA) levels and the risk of isolated distal deep vein thrombosis (IDDVT). This study aimed to explore the association among gender, SUA, and IDDVT in stroke patients.
Finally, 3404 patients were recruited and divided into two groups: IDDVT (n = 1233) and Non-IDDVT (n = 2171) groups. Propensity score matching (PSM) was conducted to match the patients. Binary logistic regression was adopted to explore the association between SUA and IDDVT, with the SUA divided into quartiles. After PSM, 975 patients were included in each group. Non-IDDVT group had a larger proportion of male than IDDVT group (64.9% vs. 52.7%, p < 0.001). Moreover, males showed higher SUA levels than females (316.7 ± 102.1 vs. 261.8 ± 94.0 μmol/L, t = 12.1, p < 0.001). The highest quartile of SUA (≥346 μmol/L) showed a lower risk of IDDVT (OR = 0.629, p = 0.001), while the lowest quartile (≤225 μmol/L) showed a higher risk of IDDVT (OR = 1.361, p = 0.022).
In patients with stroke, SUA played a protective role in IDDVT. Females had a higher risk of IDDVT, which may be owing to the lower SUA levels than males. In clinical practice, more attention should be paid to the risk of IDDVT in females, especially those with lower SUA levels.
•Female had lower uric acid levels and higher risk of IDDVT than male.•There was a U-shaped relationship between uric acid and risk of IDDVT.•Uric acid played a role in the relationship between gender and IDDVT.</description><subject>Deep vein thrombosis</subject><subject>Gender</subject><subject>Uric acid</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kL1OwzAYRS0EEuXnDRg8siTYcZ3UCxKq-JMqsdDZsv19oS5pHGyXqm9PSpmZ7nLPle4h5IazkjNe363LfrtBB2XFKl4yWTJRnZAJl4oVoqnUKZkwJVQxbaQ4JxcprRkTDRPTCVkvo3fUOA906MwegRoaQ4fU9zSvkJqUgvMm-9BTi3mH2NMP7AEjNT1QQBzoN_6WY9jYkHw6oMNIYJ8T3fm8oinH8IlX5Kw1XcLrv7wky6fH9_lLsXh7fp0_LAonhMpFI1qQrVPcSY6tVWhryVTV1BUHBBRtK_isBrS2qa0FK2eNAiVaDgYUcyAuye1xd4jha4sp641PDrvO9Bi2SVdyOqtZ1cz4WJ0eqy6GlCK2eoh-Y-Jec6YPavVaH9Xqg1rNpB7Vjtj9EcPxxrfHqJMb7zoEH9FlDcH_P_ADY5qGdw</recordid><startdate>20210826</startdate><enddate>20210826</enddate><creator>Ren, Wenwei</creator><creator>Huang, Qiqi</creator><creator>Fan, Kaili</creator><creator>Hu, Jingjie</creator><creator>Cheng, Qianqian</creator><creator>Xu, Minjie</creator><creator>Xu, Ruoting</creator><creator>Liu, Yuntao</creator><creator>Wang, Liping</creator><creator>Chen, Siyan</creator><creator>Zhang, Wanli</creator><creator>Zhu, Zhenguo</creator><creator>Wu, Chunxue</creator><creator>Xue, Langlang</creator><creator>Dai, Yanman</creator><creator>Yan, Feifan</creator><creator>Huang, Guiqian</creator><creator>He, Jincai</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210826</creationdate><title>Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke</title><author>Ren, Wenwei ; Huang, Qiqi ; Fan, Kaili ; Hu, Jingjie ; Cheng, Qianqian ; Xu, Minjie ; Xu, Ruoting ; Liu, Yuntao ; Wang, Liping ; Chen, Siyan ; Zhang, Wanli ; Zhu, Zhenguo ; Wu, Chunxue ; Xue, Langlang ; Dai, Yanman ; Yan, Feifan ; Huang, Guiqian ; He, Jincai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-73fd5fc91c51efb9eb650927621dede3ff3186debb76bbdb5879d93f1dad90cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Deep vein thrombosis</topic><topic>Gender</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Wenwei</creatorcontrib><creatorcontrib>Huang, Qiqi</creatorcontrib><creatorcontrib>Fan, Kaili</creatorcontrib><creatorcontrib>Hu, Jingjie</creatorcontrib><creatorcontrib>Cheng, Qianqian</creatorcontrib><creatorcontrib>Xu, Minjie</creatorcontrib><creatorcontrib>Xu, Ruoting</creatorcontrib><creatorcontrib>Liu, Yuntao</creatorcontrib><creatorcontrib>Wang, Liping</creatorcontrib><creatorcontrib>Chen, Siyan</creatorcontrib><creatorcontrib>Zhang, Wanli</creatorcontrib><creatorcontrib>Zhu, Zhenguo</creatorcontrib><creatorcontrib>Wu, Chunxue</creatorcontrib><creatorcontrib>Xue, Langlang</creatorcontrib><creatorcontrib>Dai, Yanman</creatorcontrib><creatorcontrib>Yan, Feifan</creatorcontrib><creatorcontrib>Huang, Guiqian</creatorcontrib><creatorcontrib>He, Jincai</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Wenwei</au><au>Huang, Qiqi</au><au>Fan, Kaili</au><au>Hu, Jingjie</au><au>Cheng, Qianqian</au><au>Xu, Minjie</au><au>Xu, Ruoting</au><au>Liu, Yuntao</au><au>Wang, Liping</au><au>Chen, Siyan</au><au>Zhang, Wanli</au><au>Zhu, Zhenguo</au><au>Wu, Chunxue</au><au>Xue, Langlang</au><au>Dai, Yanman</au><au>Yan, Feifan</au><au>Huang, Guiqian</au><au>He, Jincai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><date>2021-08-26</date><risdate>2021</risdate><volume>31</volume><issue>9</issue><spage>2700</spage><epage>2706</epage><pages>2700-2706</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Gender-specific differences were found in serum uric acid (SUA) levels and the risk of isolated distal deep vein thrombosis (IDDVT). This study aimed to explore the association among gender, SUA, and IDDVT in stroke patients.
Finally, 3404 patients were recruited and divided into two groups: IDDVT (n = 1233) and Non-IDDVT (n = 2171) groups. Propensity score matching (PSM) was conducted to match the patients. Binary logistic regression was adopted to explore the association between SUA and IDDVT, with the SUA divided into quartiles. After PSM, 975 patients were included in each group. Non-IDDVT group had a larger proportion of male than IDDVT group (64.9% vs. 52.7%, p < 0.001). Moreover, males showed higher SUA levels than females (316.7 ± 102.1 vs. 261.8 ± 94.0 μmol/L, t = 12.1, p < 0.001). The highest quartile of SUA (≥346 μmol/L) showed a lower risk of IDDVT (OR = 0.629, p = 0.001), while the lowest quartile (≤225 μmol/L) showed a higher risk of IDDVT (OR = 1.361, p = 0.022).
In patients with stroke, SUA played a protective role in IDDVT. Females had a higher risk of IDDVT, which may be owing to the lower SUA levels than males. In clinical practice, more attention should be paid to the risk of IDDVT in females, especially those with lower SUA levels.
•Female had lower uric acid levels and higher risk of IDDVT than male.•There was a U-shaped relationship between uric acid and risk of IDDVT.•Uric acid played a role in the relationship between gender and IDDVT.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.numecd.2021.05.032</doi><tpages>7</tpages></addata></record> |
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| subjects | Deep vein thrombosis Gender Uric acid |
| title | Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke |
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