Stereoselective synthesis of (−)‐cytoxazone and its unnatural congener (+)‐5‐epi‐cytoxazone

An interesting protocol for stereoselective synthesis of (−)‐cytoxazone and its unnatural stereoisomer (+)‐5‐epi‐cytoxazone from d‐4‐hydroxyphenylglycine in overall yields of 10% and 16%, respectively, is described. The stereoselective addition of cyanide to an N‐Boc protected aminoaldehyde (tert‐bu...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2021-08, Vol.33 (8), p.479-489
Hauptverfasser:	Miranda, Izabel Luzia, Santos, Pedro Henrique Costa, Kohlhoff, Markus, Purgato, Gislaine Aparecida, Diaz, Marisa Alves Nogueira, Diaz‐Muñoz, Gaspar
Format:	Artikel
Sprache:	eng
Schlagworte:	Congeners Cyanides d‐4‐hydroxyphenylglycine Isomers oxazolidinone stereoisomer Stereoisomerism Stereoisomers stereoselective addition Stereoselectivity Synthesis
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