Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development

During the development of the retina and the nervous system, high levels of energy are required by the axons of retinal ganglion cells (RGCs) to grow towards their brain targets. This energy demand leads to an increase of glycolysis and L-lactate concentrations in the retina. L-lactate is known to b...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2021-06, Vol.10 (7), p.1640
Hauptverfasser:	Laroche, Samuel, Stil, Aurélie, Germain, Philippe, Cherif, Hosni, Chemtob, Sylvain, Bouchard, Jean-François
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Axon guidance Axons - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism dLGN DNA polymerase Explants Filopodia Glycolysis GPR81 growth cone Growth Cones - metabolism HCAR1 Immunohistochemistry lactate Lactates - metabolism Lactic acid Lateral geniculate nucleus Metabolism Mice Mice, Inbred C57BL Morphology Nervous system Nervous System - embryology Phosphorylation Physiology Potassium Protein kinase Protein Kinase C - metabolism Receptors, G-Protein-Coupled - metabolism Retina Retina - metabolism Retinal ganglion cells Sucrose Thalamus - metabolism Transgenic mice Vision, Ocular - physiology
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