May oxygen depletion explain the FLASH effect? A chemical track structure analysis

•Bottom-up radiation chemistry study reproduced observed radiolytic oxygen depletion (ROD) with high accuracy.•Dynamical nature of oxygen depletion and its impact on OER taken into account for the first time.•Negligible impact of ROD on radiosensitivity through transient hypoxia in conditions of rep...

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Veröffentlicht in:	Radiotherapy and oncology 2021-09, Vol.162, p.68-75
Hauptverfasser:	Boscolo, Daria, Scifoni, Emanuele, Durante, Marco, Krämer, Michael, Fuss, Martina C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Electrons FLASH effect mechanism Monte Carlo Method Oxygen Oxygen Consumption Oxygen depletion Radiation track structure simulation Radiobiology Reactive oxygen species
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