Noninvasively visualize the expression of LAPTM4B protein using a novel 18F-labeled peptide PET probe in hepatocellular carcinoma

Lysosomal protein transmembrane 4 beta (LAPTM4B) is selectively expressed in hepatocellular carcinoma (HCC) cells and thus a potential biomarker for diagnosing HCC. In this study, we designed a novel 18F-labeled PET probe to non-invasively visualize LAPTM4B expression in mouse model of HCC tumor. A...

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Veröffentlicht in:	Nuclear medicine and biology 2021-09, Vol.100-101, p.52-60
Hauptverfasser:	Ren, Yunyan, Hu, Kongzhen, Bi, Lei, Wu, Hong, Li, Youcai, Han, Yanjiang, Zhou, Wenlan, Li, Hongsheng, Jin, Hongjun, Wu, Hubing
Format:	Artikel
Sprache:	eng
Schlagworte:	AP2H peptide Biodistribution Biomarkers Computed tomography Fluorine isotopes Hepatocellular carcinoma In vivo methods and tests LAPTM4B Liver Liver cancer Lysosomal protein Peptides PET Positron emission Protein targeting imaging Proteins Radioactivity Radiochemistry Stability Synthesis Tomography Tumors
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