Disordered glycemic control in women with type 2 diabetes is associated with increased TNF receptor-2 levels
Evidence implicates tumor necrosis factor (TNF) in the pathophysiology of Type 2 Diabetes (T2D) through unclear mechanisms. We hypothesized that disordered glycemic control leads to TNF activation and increases in soluble-TNF (sTNF) and its receptors-1 (sTNFR1) and -2 (sTNFR2). We characterized 265...
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| Veröffentlicht in: | Journal of diabetes and its complications 2021-09, Vol.35 (9), p.107974-107974, Article 107974 |
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| container_title | Journal of diabetes and its complications |
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| creator | Pulido-Perez, Patricia Torres-Rasgado, Enrique Pérez-Fuentes, Ricardo Rosales-Encina, José Luis Rodríguez-Antolín, Jorge Romero, Jose R. |
| description | Evidence implicates tumor necrosis factor (TNF) in the pathophysiology of Type 2 Diabetes (T2D) through unclear mechanisms. We hypothesized that disordered glycemic control leads to TNF activation and increases in soluble-TNF (sTNF) and its receptors-1 (sTNFR1) and -2 (sTNFR2).
We characterized 265 T2D and non-diabetic Latin American subjects and assessed the relationship between the TNF system and fasting plasma glucose (FPG), hemoglobin-A1C (A1C), insulin (FPI), C-peptide and HOMA-Beta.
sTNF and sTNFR2 but not sTNFR1 levels were higher in T2D than non-diabetics (P |
| doi_str_mv | 10.1016/j.jdiacomp.2021.107974 |
| format | Article |
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We characterized 265 T2D and non-diabetic Latin American subjects and assessed the relationship between the TNF system and fasting plasma glucose (FPG), hemoglobin-A1C (A1C), insulin (FPI), C-peptide and HOMA-Beta.
sTNF and sTNFR2 but not sTNFR1 levels were higher in T2D than non-diabetics (P<0.0001). In T2D, sTNFR2 was associated with A1C and C-peptide (R2=0.354, b=0.504, P<0.0001; b=0.167, P=0.049). Also, T2D patients with disordered glycemic control had increased sTNFR2 levels that correlated with FPG (Rho:0.393, P<0.001), A1C (Rho:0.451, P<0.001) and HOMA-Beta (Rho:-0.308, P=0.005); events not observed in T2D patients with adequate glycemic control. Furthermore, sex-based comparative analyses of T2D patients showed that women compared to men had higher sTNFR2 levels (P=0.017) that correlated with FPG, A1C, FPI and HOMA-Beta.
Disordered glycemic control is associated with sTNF and sTNFR2. sTNFR2 levels were higher in T2D women than men. Thus, increased sTNFR2 levels may be an important biomarker for disordered glucose and inflammatory complications in T2D patients and women in particular.
•sTNF and sTNFR2 but not sTNFR1 levels are higher in T2D than non-diabetic subjects.•Disordered glycemic control is associated with increased sTNF and sTNFR2 levels.•Women with T2D had higher sTNFR2 levels than men with T2D.•sTNFR2 in T2D women is associated with disordered glycemic control.</description><identifier>ISSN: 1056-8727</identifier><identifier>EISSN: 1873-460X</identifier><identifier>DOI: 10.1016/j.jdiacomp.2021.107974</identifier><identifier>PMID: 34210601</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Body mass index ; C-Peptide ; Cholesterol ; Cytokines ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Disease ; Disordered glycemic control ; Enzymes ; Female ; Glucose ; Glycated Hemoglobin A - analysis ; Glycemic Control ; Hispanic people ; Humans ; Insulin resistance ; Male ; Metabolism ; Overweight ; Pathophysiology ; Peptides ; Plasma ; Receptors, Tumor Necrosis Factor, Type II - blood ; Regression analysis ; Sex difference ; Soluble TNF system ; sTNFR2 ; Tumor Necrosis Factor-alpha - blood ; Tumor necrosis factor-TNF ; Type 2 diabetes ; Womens health</subject><ispartof>Journal of diabetes and its complications, 2021-09, Vol.35 (9), p.107974-107974, Article 107974</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><rights>2021. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-6dbeece8c57165bcc9b973996e677d27e71194897f11bf27d5046898dd5eadb23</citedby><cites>FETCH-LOGICAL-c396t-6dbeece8c57165bcc9b973996e677d27e71194897f11bf27d5046898dd5eadb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1056872721001719$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34210601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pulido-Perez, Patricia</creatorcontrib><creatorcontrib>Torres-Rasgado, Enrique</creatorcontrib><creatorcontrib>Pérez-Fuentes, Ricardo</creatorcontrib><creatorcontrib>Rosales-Encina, José Luis</creatorcontrib><creatorcontrib>Rodríguez-Antolín, Jorge</creatorcontrib><creatorcontrib>Romero, Jose R.</creatorcontrib><title>Disordered glycemic control in women with type 2 diabetes is associated with increased TNF receptor-2 levels</title><title>Journal of diabetes and its complications</title><addtitle>J Diabetes Complications</addtitle><description>Evidence implicates tumor necrosis factor (TNF) in the pathophysiology of Type 2 Diabetes (T2D) through unclear mechanisms. We hypothesized that disordered glycemic control leads to TNF activation and increases in soluble-TNF (sTNF) and its receptors-1 (sTNFR1) and -2 (sTNFR2).
We characterized 265 T2D and non-diabetic Latin American subjects and assessed the relationship between the TNF system and fasting plasma glucose (FPG), hemoglobin-A1C (A1C), insulin (FPI), C-peptide and HOMA-Beta.
sTNF and sTNFR2 but not sTNFR1 levels were higher in T2D than non-diabetics (P<0.0001). In T2D, sTNFR2 was associated with A1C and C-peptide (R2=0.354, b=0.504, P<0.0001; b=0.167, P=0.049). Also, T2D patients with disordered glycemic control had increased sTNFR2 levels that correlated with FPG (Rho:0.393, P<0.001), A1C (Rho:0.451, P<0.001) and HOMA-Beta (Rho:-0.308, P=0.005); events not observed in T2D patients with adequate glycemic control. Furthermore, sex-based comparative analyses of T2D patients showed that women compared to men had higher sTNFR2 levels (P=0.017) that correlated with FPG, A1C, FPI and HOMA-Beta.
Disordered glycemic control is associated with sTNF and sTNFR2. sTNFR2 levels were higher in T2D women than men. Thus, increased sTNFR2 levels may be an important biomarker for disordered glucose and inflammatory complications in T2D patients and women in particular.
•sTNF and sTNFR2 but not sTNFR1 levels are higher in T2D than non-diabetic subjects.•Disordered glycemic control is associated with increased sTNF and sTNFR2 levels.•Women with T2D had higher sTNFR2 levels than men with T2D.•sTNFR2 in T2D women is associated with disordered glycemic control.</description><subject>Body mass index</subject><subject>C-Peptide</subject><subject>Cholesterol</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Disease</subject><subject>Disordered glycemic control</subject><subject>Enzymes</subject><subject>Female</subject><subject>Glucose</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Glycemic Control</subject><subject>Hispanic people</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Male</subject><subject>Metabolism</subject><subject>Overweight</subject><subject>Pathophysiology</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Receptors, Tumor Necrosis Factor, Type II - blood</subject><subject>Regression analysis</subject><subject>Sex difference</subject><subject>Soluble TNF system</subject><subject>sTNFR2</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor necrosis factor-TNF</subject><subject>Type 2 diabetes</subject><subject>Womens health</subject><issn>1056-8727</issn><issn>1873-460X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1v1DAQhi0EoqXwFypLXLhk8Tjx1w1UaEGq6KWVuFmJPQuOkjjY3qL997jdlkMvvfhLzztjzUPIKbANMJAfx83oQ-_ivG4441AflVHdC3IMWrVNJ9nPl_XMhGy04uqIvMl5ZIxJIeA1OWo7DkwyOCbTl5Bj8pjQ01_T3uEcHHVxKSlONCz0b5yxrqH8pmW_IuW0th2wYKYh0z7n6EJfavgeCYtL2Od6vf5xThM6XEtMDacT3uKU35JX237K-O5hPyE351-vz741l1cX388-XzauNbI00g9Yo9oJBVIMzpnBqNYYiVIpzxUqANNpo7YAw5YrL1gntdHeC-z9wNsT8uFQd03xzw5zsXPIDqepXzDusuWi0x0A17qi75-gY9ylpf6uUkJ1wFtQlZIHyqWYc8KtXVOY-7S3wOydDzvaRx_2zoc9-KjB04fyu2FG_z_2KKACnw5AHQ_eBkw2u4CLQx_q-Ir1MTzX4x9KRp8o</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Pulido-Perez, Patricia</creator><creator>Torres-Rasgado, Enrique</creator><creator>Pérez-Fuentes, Ricardo</creator><creator>Rosales-Encina, José Luis</creator><creator>Rodríguez-Antolín, Jorge</creator><creator>Romero, Jose R.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202109</creationdate><title>Disordered glycemic control in women with type 2 diabetes is associated with increased TNF receptor-2 levels</title><author>Pulido-Perez, Patricia ; Torres-Rasgado, Enrique ; Pérez-Fuentes, Ricardo ; Rosales-Encina, José Luis ; Rodríguez-Antolín, Jorge ; Romero, Jose R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-6dbeece8c57165bcc9b973996e677d27e71194897f11bf27d5046898dd5eadb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Body mass index</topic><topic>C-Peptide</topic><topic>Cholesterol</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Disease</topic><topic>Disordered glycemic control</topic><topic>Enzymes</topic><topic>Female</topic><topic>Glucose</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Glycemic Control</topic><topic>Hispanic people</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Male</topic><topic>Metabolism</topic><topic>Overweight</topic><topic>Pathophysiology</topic><topic>Peptides</topic><topic>Plasma</topic><topic>Receptors, Tumor Necrosis Factor, Type II - blood</topic><topic>Regression analysis</topic><topic>Sex difference</topic><topic>Soluble TNF system</topic><topic>sTNFR2</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor necrosis factor-TNF</topic><topic>Type 2 diabetes</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pulido-Perez, Patricia</creatorcontrib><creatorcontrib>Torres-Rasgado, Enrique</creatorcontrib><creatorcontrib>Pérez-Fuentes, Ricardo</creatorcontrib><creatorcontrib>Rosales-Encina, José Luis</creatorcontrib><creatorcontrib>Rodríguez-Antolín, Jorge</creatorcontrib><creatorcontrib>Romero, Jose R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of diabetes and its complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pulido-Perez, Patricia</au><au>Torres-Rasgado, Enrique</au><au>Pérez-Fuentes, Ricardo</au><au>Rosales-Encina, José Luis</au><au>Rodríguez-Antolín, Jorge</au><au>Romero, Jose R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disordered glycemic control in women with type 2 diabetes is associated with increased TNF receptor-2 levels</atitle><jtitle>Journal of diabetes and its complications</jtitle><addtitle>J Diabetes Complications</addtitle><date>2021-09</date><risdate>2021</risdate><volume>35</volume><issue>9</issue><spage>107974</spage><epage>107974</epage><pages>107974-107974</pages><artnum>107974</artnum><issn>1056-8727</issn><eissn>1873-460X</eissn><abstract>Evidence implicates tumor necrosis factor (TNF) in the pathophysiology of Type 2 Diabetes (T2D) through unclear mechanisms. We hypothesized that disordered glycemic control leads to TNF activation and increases in soluble-TNF (sTNF) and its receptors-1 (sTNFR1) and -2 (sTNFR2).
We characterized 265 T2D and non-diabetic Latin American subjects and assessed the relationship between the TNF system and fasting plasma glucose (FPG), hemoglobin-A1C (A1C), insulin (FPI), C-peptide and HOMA-Beta.
sTNF and sTNFR2 but not sTNFR1 levels were higher in T2D than non-diabetics (P<0.0001). In T2D, sTNFR2 was associated with A1C and C-peptide (R2=0.354, b=0.504, P<0.0001; b=0.167, P=0.049). Also, T2D patients with disordered glycemic control had increased sTNFR2 levels that correlated with FPG (Rho:0.393, P<0.001), A1C (Rho:0.451, P<0.001) and HOMA-Beta (Rho:-0.308, P=0.005); events not observed in T2D patients with adequate glycemic control. Furthermore, sex-based comparative analyses of T2D patients showed that women compared to men had higher sTNFR2 levels (P=0.017) that correlated with FPG, A1C, FPI and HOMA-Beta.
Disordered glycemic control is associated with sTNF and sTNFR2. sTNFR2 levels were higher in T2D women than men. Thus, increased sTNFR2 levels may be an important biomarker for disordered glucose and inflammatory complications in T2D patients and women in particular.
•sTNF and sTNFR2 but not sTNFR1 levels are higher in T2D than non-diabetic subjects.•Disordered glycemic control is associated with increased sTNF and sTNFR2 levels.•Women with T2D had higher sTNFR2 levels than men with T2D.•sTNFR2 in T2D women is associated with disordered glycemic control.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34210601</pmid><doi>10.1016/j.jdiacomp.2021.107974</doi><tpages>1</tpages></addata></record> |
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| ispartof | Journal of diabetes and its complications, 2021-09, Vol.35 (9), p.107974-107974, Article 107974 |
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| subjects | Body mass index C-Peptide Cholesterol Cytokines Diabetes Diabetes Mellitus, Type 2 - complications Disease Disordered glycemic control Enzymes Female Glucose Glycated Hemoglobin A - analysis Glycemic Control Hispanic people Humans Insulin resistance Male Metabolism Overweight Pathophysiology Peptides Plasma Receptors, Tumor Necrosis Factor, Type II - blood Regression analysis Sex difference Soluble TNF system sTNFR2 Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF Type 2 diabetes Womens health |
| title | Disordered glycemic control in women with type 2 diabetes is associated with increased TNF receptor-2 levels |
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