Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene expression

To understand how chromatin domains coordinate gene expression, we dissected select genetic elements organizing topology and transcription around the Prdm14 super enhancer in mouse embryonic stem cells. Taking advantage of allelic polymorphisms, we developed methods to sensitively analyze changes in...

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Veröffentlicht in:	Molecular cell 2021-08, Vol.81 (15), p.3082-3095.e6
Hauptverfasser:	Vos, Erica S.M., Valdes-Quezada, Christian, Huang, Yike, Allahyar, Amin, Verstegen, Marjon J.A.M., Felder, Anna-Karina, van der Vegt, Floor, Uijttewaal, Esther C.H., Krijger, Peter H.L., de Laat, Wouter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CCCTC-Binding Factor - genetics CCCTC-Binding Factor - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism chromatin Chromatin - genetics Chromatin - metabolism Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism cohesin Cohesins CTCF DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism domains Enhancer Elements, Genetic enhancers Gene Expression gene regulation genome organization loop extrusion loops Mice Mouse Embryonic Stem Cells Nuclear Receptor Coactivator 2 - genetics Promoter Regions, Genetic RNA-Binding Proteins - genetics TADs Transcription Factors - genetics
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