Overexpression of microRNA-100-5p attenuates the endothelial cell dysfunction by targeting HIPK2 under hypoxia and reoxygenation treatment

MicroRNAs (miRNAs) are important regulators of many cellular processes, and the dysregulation of miRNAs is associated with various diseases. MiR-100-5p is revealed to be downregulated in gestational hypertension, while its underlying regulatory mechanism remains unclear. The pathological condition o...

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Veröffentlicht in:	Journal of molecular histology 2021-10, Vol.52 (5), p.1115-1125
Hauptverfasser:	Zheng, Haoyu, Sun, Yanlan, Shu, Xiaoming, Gao, Qiong, Chen, Xiaoqin
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Base Sequence Biomedical and Life Sciences Biomedicine Carrier Proteins - metabolism Cell Biology Cell Hypoxia - drug effects Cell Hypoxia - genetics Cell Proliferation - drug effects Cholecystokinin Developmental Biology Down-Regulation - drug effects Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Enzyme-linked immunosorbent assay Female Gene expression HIPK2 protein Homeobox Humans Hypertension Hypoxia Kinases Life Sciences MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Microvasculature Microvessels - pathology miRNA mRNA Neovascularization, Physiologic - drug effects Original Paper Oxygen - pharmacology Phosphatidylinositol 3-Kinases - metabolism Placenta - blood supply Pregnancy Protein kinase Protein Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins c-akt - metabolism Viability Western blotting
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