Serine hydroxymethyltransferase 2: a novel target for human cancer therapy

Summary Serine and glycine are the primary sources of one-carbon units that are vital for cell proliferation. Their abnormal metabolism is known to be associated with cancer progression. As the key enzyme of serine metabolism, Serine Hydroxymethyltransferase 2 (SHMT2) has been a research hotspot in...

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Veröffentlicht in:	Investigational new drugs 2021-12, Vol.39 (6), p.1671-1681
Hauptverfasser:	Xie, Min, Pei, Dong-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Cancer Cancer therapies Carbon Carbon sources Cell growth Cell proliferation Cell Proliferation - physiology Deubiquitinating Enzymes - metabolism Drug Resistance - physiology Enzymes Epigenetics Glutathione Glutathione - metabolism Glycine Glycine Hydroxymethyltransferase - metabolism Humans Hypoxia Hypoxia - physiopathology Medicine Medicine & Public Health Metabolism Molecular modelling NADP - metabolism NADPH-diaphorase Neoplasms - physiopathology Nicotinamide Nicotinamide adenine dinucleotide Oncology Pharmacology/Toxicology Pyruvate Kinase - metabolism Review Serine Sirtuins - metabolism STAT3 Transcription Factor - metabolism Tumors
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