Spleen route accelerates engraftment of human hematopoietic stem cells

Intravenous injections of human hematopoietic stem cells (hHSCs) is routinely used in clinic and for modeling hematopoiesis in mice. However, unspecific dilution in vascular system and non-hematopoietic organs challenges engraftment efficiency. Although spleen is capable of extra medullar hematopoie...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-09, Vol.569, p.23-28
Hauptverfasser:	Bedel, A., Boutin, J., Amintas, S., Lamrissi-Garcia, I., Rousseau, B., Poglio, S., Brunet de la Grange, P., Moranvillier, I., Blouin, J.M., Richard, E., Moreau-Gaudry, F., Dabernat, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - metabolism Extra-medullar hematopoiesis Female Flow Cytometry - methods Graft Graft Survival - physiology Hematopoiesis - physiology Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism HSC Humans Injections Luciferases - genetics Luciferases - metabolism Luminescent Measurements - methods Mice Mice, Inbred NOD Mice, Knockout Mice, SCID Spleen Spleen - cytology Spleen - metabolism Transplantation Chimera Transplantation, Heterologous
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