Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

Aneuploidy, an unbalanced number of chromosomes, is highly deleterious at the cellular level and leads to senescence, a stress-induced response characterized by permanent cell-cycle arrest and a well-defined associated secretory phenotype. Here, we use a Drosophila epithelial model to delineate the...

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Veröffentlicht in:	Developmental cell 2021-07, Vol.56 (14), p.2043-2058.e7
Hauptverfasser:	Joy, Jery, Barrio, Lara, Santos-Tapia, Celia, Romão, Daniela, Giakoumakis, Nikolaos Nikiforos, Clemente-Ruiz, Marta, Milán, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	aneuploidy autophagy chromosomal instability Drosophila mitochondrial dysfunction mitophagy proteotoxic stress senescence tissue repair
Online-Zugang:	Volltext
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