Development and Full Validation of a Bioanalytical Method for Quantifying Letermovir in Human Plasma Using Ultra-Performance Liquid Chromatography Coupled with Mass Spectrometry

With the aim of studying the pharmacokinetics of letermovir, which is a newly developed antiviral agent for human cytomegalovirus, a rapid and simple ultra-performance liquid chromatography coupled with mass spectrometry (UPLC/MS) method was developed and validated for the quantification of letermov...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2021/07/01, Vol.69(7), pp.646-651
Hauptverfasser:	Belabbas, Tassadit, Yamada, Takaaki, Tsuchiya, Yuichi, Suetsugu, Kimitaka, Egashira, Nobuaki, Ieiri, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Acetonitrile Ammonium Ammonium acetate Antiviral drugs bioanalytical method development Blood plasma Chromatography Coupling Dilution Flow velocity Formic acid Human performance human plasma Ions letermovir Liquid chromatography Mass spectrometry Mass spectroscopy Pharmacodynamics Pharmacokinetics Pharmacology Regression analysis Scientific imaging Spectroscopy ultra-performance liquid chromatography coupled with mass spectrometry validation
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