Establishment of a new valid animal model for the evaluation of hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric rhabdomyosarcoma

Background Cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy has been established as a novel treatment approach for peritoneal sarcomatosis. Despite promising clinical reports, there is still a lack of knowledge regarding optimal drug usage and local effects. Theref...

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Veröffentlicht in:	Pediatric blood & cancer 2021-11, Vol.68 (11), p.e29202-n/a
Hauptverfasser:	Wagner, Benedikt R., Adamus, Anna L., Sönnecken, Dörthe, Vahdad, Reza, Jank, Paul, Denkert, Carsten, Mahnken, Andreas H., Seitz, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	alveolar rhabdomyosarcoma Alveoli animal model Animal models Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Caspase-3 Chemotherapy Child Cisplatin Cisplatin - therapeutic use Combined Modality Therapy cytoreductive surgery (CRS) Disease Models, Animal Gastric cancer Hematology Humans Hyperthermic Intraperitoneal Chemotherapy hyperthermic intraperitoneal chemotherapy (HIPEC) Ki-67 Antigen Magnetic resonance imaging Mice Mice, Inbred NOD Oncology Pediatrics Perfusion Peritoneal Neoplasms - therapy Peritoneum Rhabdomyosarcoma Rhabdomyosarcoma, Embryonal - therapy Tumors Xenograft Model Antitumor Assays Xenografts
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