Sex differences in the vascular response to sympathetic activation during acute hypoxaemia
New Findings What is the central question of this study? Sympathetically mediated vasoconstriction is preserved during hypoxaemia in humans, but our understanding of vascular control comes from predominantly male cohorts. We tested the hypothesis that young women attenuate sympathetically mediated v...
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| Veröffentlicht in: | Experimental physiology 2021-08, Vol.106 (8), p.1689-1698 |
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| creator | Jacob, Dain W. Harper, Jennifer L. Ivie, Clayton L. Ott, Elizabeth P. Limberg, Jacqueline K. |
| description | New Findings
What is the central question of this study?
Sympathetically mediated vasoconstriction is preserved during hypoxaemia in humans, but our understanding of vascular control comes from predominantly male cohorts. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady‐state hypoxaemia, whereas men do not?
What is the main finding and its importance?
Sympathetically mediated vasoconstriction is preserved or even enhanced during steady‐state hypoxia in young men, and the peripheral vascular response to sympathetic activation during hypoxaemia is attenuated in young women. These data advance our understanding of sex‐related differences in hypoxic vascular control.
Activation of the sympathetic nervous system causes vasoconstriction and a reduction in peripheral blood flow. Sympathetically mediated vasoconstriction may be attenuated during systemic hypoxia to maintain oxygen delivery; however, in predominantly male participants sympathetically mediated vasoconstriction is preserved or even enhanced during hypoxaemia. Given the potential for sex‐specific differences in hypoxic vascular control, prior results are limited in application. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady‐state hypoxaemia, whereas men do not. Healthy young men (n = 13, 25 ± 4 years) and women (n = 11, 24 ± 4 years) completed two trials consisting of a 2‐min cold pressor test (CPT, a well‐established sympathoexcitatory stimulus) during baseline normoxia and steady‐state hypoxaemia. Beat‐to‐beat blood pressure (finger photoplethysmography) and forearm blood flow (venous occlusion plethysmography) were measured continuously. Total and forearm vascular conductance (TVC and FVC, respectfully) were calculated. A change (Δ) in TVC and FVC from steady‐state during the last 1 min of CPT was calculated and differences between normoxia and systemic hypoxia were assessed. In men, the reduction in TVC during CPT was greater during hypoxia compared to normoxia (ΔTVC, P = 0.02), whereas ΔTVC did not differ between conditions in women (P = 0.49). In men, ΔFVC did not differ between normoxia and hypoxia (P = 0.92). In women, the reduction in FVC during CPT was attenuated during hypoxia (ΔFVC, P |
| doi_str_mv | 10.1113/EP089461 |
| format | Article |
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What is the central question of this study?
Sympathetically mediated vasoconstriction is preserved during hypoxaemia in humans, but our understanding of vascular control comes from predominantly male cohorts. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady‐state hypoxaemia, whereas men do not?
What is the main finding and its importance?
Sympathetically mediated vasoconstriction is preserved or even enhanced during steady‐state hypoxia in young men, and the peripheral vascular response to sympathetic activation during hypoxaemia is attenuated in young women. These data advance our understanding of sex‐related differences in hypoxic vascular control.
Activation of the sympathetic nervous system causes vasoconstriction and a reduction in peripheral blood flow. Sympathetically mediated vasoconstriction may be attenuated during systemic hypoxia to maintain oxygen delivery; however, in predominantly male participants sympathetically mediated vasoconstriction is preserved or even enhanced during hypoxaemia. Given the potential for sex‐specific differences in hypoxic vascular control, prior results are limited in application. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady‐state hypoxaemia, whereas men do not. Healthy young men (n = 13, 25 ± 4 years) and women (n = 11, 24 ± 4 years) completed two trials consisting of a 2‐min cold pressor test (CPT, a well‐established sympathoexcitatory stimulus) during baseline normoxia and steady‐state hypoxaemia. Beat‐to‐beat blood pressure (finger photoplethysmography) and forearm blood flow (venous occlusion plethysmography) were measured continuously. Total and forearm vascular conductance (TVC and FVC, respectfully) were calculated. A change (Δ) in TVC and FVC from steady‐state during the last 1 min of CPT was calculated and differences between normoxia and systemic hypoxia were assessed. In men, the reduction in TVC during CPT was greater during hypoxia compared to normoxia (ΔTVC, P = 0.02), whereas ΔTVC did not differ between conditions in women (P = 0.49). In men, ΔFVC did not differ between normoxia and hypoxia (P = 0.92). In women, the reduction in FVC during CPT was attenuated during hypoxia (ΔFVC, P < 0.01). We confirm sympathetically mediated vasoconstriction is preserved or enhanced during hypoxaemia in young men, whereas peripheral vascular responsiveness to sympathetic activation during hypoxaemia is attenuated in young women. The results advance our understanding of sex‐related differences in hypoxic vascular control.</description><identifier>ISSN: 0958-0670</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/EP089461</identifier><identifier>PMID: 34187092</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Blood flow ; Blood Pressure ; Female ; Forearm ; Forearm - blood supply ; forearm blood flow ; Humans ; Hypoxia ; Male ; Occlusion ; Peripheral blood ; Regional Blood Flow - physiology ; Sex Characteristics ; Sex differences ; Sympathetic nervous system ; Sympathetic Nervous System - physiology ; vascular resistance ; Vasoconstriction ; Vasoconstriction - physiology ; women ; Young adults</subject><ispartof>Experimental physiology, 2021-08, Vol.106 (8), p.1689-1698</ispartof><rights>2021 The Authors. Experimental Physiology © 2021 The Physiological Society</rights><rights>2021 The Authors. Experimental Physiology © 2021 The Physiological Society.</rights><rights>2021 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3847-b975a1a92a00ebc91d1927d43e7aa34d03c5de279608763b31d7440315bb9a4d3</citedby><cites>FETCH-LOGICAL-c3847-b975a1a92a00ebc91d1927d43e7aa34d03c5de279608763b31d7440315bb9a4d3</cites><orcidid>0000-0001-9982-5851</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2FEP089461$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2FEP089461$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34187092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacob, Dain W.</creatorcontrib><creatorcontrib>Harper, Jennifer L.</creatorcontrib><creatorcontrib>Ivie, Clayton L.</creatorcontrib><creatorcontrib>Ott, Elizabeth P.</creatorcontrib><creatorcontrib>Limberg, Jacqueline K.</creatorcontrib><title>Sex differences in the vascular response to sympathetic activation during acute hypoxaemia</title><title>Experimental physiology</title><addtitle>Exp Physiol</addtitle><description>New Findings
What is the central question of this study?
Sympathetically mediated vasoconstriction is preserved during hypoxaemia in humans, but our understanding of vascular control comes from predominantly male cohorts. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady‐state hypoxaemia, whereas men do not?
What is the main finding and its importance?
Sympathetically mediated vasoconstriction is preserved or even enhanced during steady‐state hypoxia in young men, and the peripheral vascular response to sympathetic activation during hypoxaemia is attenuated in young women. These data advance our understanding of sex‐related differences in hypoxic vascular control.
Activation of the sympathetic nervous system causes vasoconstriction and a reduction in peripheral blood flow. Sympathetically mediated vasoconstriction may be attenuated during systemic hypoxia to maintain oxygen delivery; however, in predominantly male participants sympathetically mediated vasoconstriction is preserved or even enhanced during hypoxaemia. Given the potential for sex‐specific differences in hypoxic vascular control, prior results are limited in application. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady‐state hypoxaemia, whereas men do not. Healthy young men (n = 13, 25 ± 4 years) and women (n = 11, 24 ± 4 years) completed two trials consisting of a 2‐min cold pressor test (CPT, a well‐established sympathoexcitatory stimulus) during baseline normoxia and steady‐state hypoxaemia. Beat‐to‐beat blood pressure (finger photoplethysmography) and forearm blood flow (venous occlusion plethysmography) were measured continuously. Total and forearm vascular conductance (TVC and FVC, respectfully) were calculated. A change (Δ) in TVC and FVC from steady‐state during the last 1 min of CPT was calculated and differences between normoxia and systemic hypoxia were assessed. In men, the reduction in TVC during CPT was greater during hypoxia compared to normoxia (ΔTVC, P = 0.02), whereas ΔTVC did not differ between conditions in women (P = 0.49). In men, ΔFVC did not differ between normoxia and hypoxia (P = 0.92). In women, the reduction in FVC during CPT was attenuated during hypoxia (ΔFVC, P < 0.01). We confirm sympathetically mediated vasoconstriction is preserved or enhanced during hypoxaemia in young men, whereas peripheral vascular responsiveness to sympathetic activation during hypoxaemia is attenuated in young women. The results advance our understanding of sex‐related differences in hypoxic vascular control.</description><subject>Blood flow</subject><subject>Blood Pressure</subject><subject>Female</subject><subject>Forearm</subject><subject>Forearm - blood supply</subject><subject>forearm blood flow</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Male</subject><subject>Occlusion</subject><subject>Peripheral blood</subject><subject>Regional Blood Flow - physiology</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Sympathetic nervous system</subject><subject>Sympathetic Nervous System - physiology</subject><subject>vascular resistance</subject><subject>Vasoconstriction</subject><subject>Vasoconstriction - physiology</subject><subject>women</subject><subject>Young adults</subject><issn>0958-0670</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1LxDAQhoMo7voB_gIJePFSTZq0aY4iqyssKKggXkqazLqRtqlJu9p_b8QvEDzNMPPwMjyD0AElJ5RSdjq7IYXkOd1AU8pzmXCePWyiKZFZkZBckAnaCeGZEMpIwbfRhHFaCCLTKXq8hTds7HIJHloNAdsW9yvAaxX0UCuPPYTOtQFw73AYm07FbW81Vrq3a9Vb12IzeNs-xcnQA16NnXtT0Fi1h7aWqg6w_1V30f3F7O58niyuL6_OzxaJZgUXSSVFpqiSqSIEKi2poTIVhjMQSjFuCNOZgVTInBQiZxWjRnBOGM2qSipu2C46_sztvHsZIPRlY4OGulYtuCGUaRaViKgijejRH_TZDb6N10UqyykXeSZ_A7V3IXhYlp23jfJjSUn54bv89h3Rw6_AoWrA_IDfgiNw8gm82hrGf4NiM4_P4YK9A3T-h7Y</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Jacob, Dain W.</creator><creator>Harper, Jennifer L.</creator><creator>Ivie, Clayton L.</creator><creator>Ott, Elizabeth P.</creator><creator>Limberg, Jacqueline K.</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9982-5851</orcidid></search><sort><creationdate>20210801</creationdate><title>Sex differences in the vascular response to sympathetic activation during acute hypoxaemia</title><author>Jacob, Dain W. ; Harper, Jennifer L. ; Ivie, Clayton L. ; Ott, Elizabeth P. ; Limberg, Jacqueline K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3847-b975a1a92a00ebc91d1927d43e7aa34d03c5de279608763b31d7440315bb9a4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Blood flow</topic><topic>Blood Pressure</topic><topic>Female</topic><topic>Forearm</topic><topic>Forearm - blood supply</topic><topic>forearm blood flow</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Male</topic><topic>Occlusion</topic><topic>Peripheral blood</topic><topic>Regional Blood Flow - physiology</topic><topic>Sex Characteristics</topic><topic>Sex differences</topic><topic>Sympathetic nervous system</topic><topic>Sympathetic Nervous System - physiology</topic><topic>vascular resistance</topic><topic>Vasoconstriction</topic><topic>Vasoconstriction - physiology</topic><topic>women</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacob, Dain W.</creatorcontrib><creatorcontrib>Harper, Jennifer L.</creatorcontrib><creatorcontrib>Ivie, Clayton L.</creatorcontrib><creatorcontrib>Ott, Elizabeth P.</creatorcontrib><creatorcontrib>Limberg, Jacqueline K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacob, Dain W.</au><au>Harper, Jennifer L.</au><au>Ivie, Clayton L.</au><au>Ott, Elizabeth P.</au><au>Limberg, Jacqueline K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in the vascular response to sympathetic activation during acute hypoxaemia</atitle><jtitle>Experimental physiology</jtitle><addtitle>Exp Physiol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>106</volume><issue>8</issue><spage>1689</spage><epage>1698</epage><pages>1689-1698</pages><issn>0958-0670</issn><eissn>1469-445X</eissn><abstract>New Findings
What is the central question of this study?
Sympathetically mediated vasoconstriction is preserved during hypoxaemia in humans, but our understanding of vascular control comes from predominantly male cohorts. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady‐state hypoxaemia, whereas men do not?
What is the main finding and its importance?
Sympathetically mediated vasoconstriction is preserved or even enhanced during steady‐state hypoxia in young men, and the peripheral vascular response to sympathetic activation during hypoxaemia is attenuated in young women. These data advance our understanding of sex‐related differences in hypoxic vascular control.
Activation of the sympathetic nervous system causes vasoconstriction and a reduction in peripheral blood flow. Sympathetically mediated vasoconstriction may be attenuated during systemic hypoxia to maintain oxygen delivery; however, in predominantly male participants sympathetically mediated vasoconstriction is preserved or even enhanced during hypoxaemia. Given the potential for sex‐specific differences in hypoxic vascular control, prior results are limited in application. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady‐state hypoxaemia, whereas men do not. Healthy young men (n = 13, 25 ± 4 years) and women (n = 11, 24 ± 4 years) completed two trials consisting of a 2‐min cold pressor test (CPT, a well‐established sympathoexcitatory stimulus) during baseline normoxia and steady‐state hypoxaemia. Beat‐to‐beat blood pressure (finger photoplethysmography) and forearm blood flow (venous occlusion plethysmography) were measured continuously. Total and forearm vascular conductance (TVC and FVC, respectfully) were calculated. A change (Δ) in TVC and FVC from steady‐state during the last 1 min of CPT was calculated and differences between normoxia and systemic hypoxia were assessed. In men, the reduction in TVC during CPT was greater during hypoxia compared to normoxia (ΔTVC, P = 0.02), whereas ΔTVC did not differ between conditions in women (P = 0.49). In men, ΔFVC did not differ between normoxia and hypoxia (P = 0.92). In women, the reduction in FVC during CPT was attenuated during hypoxia (ΔFVC, P < 0.01). We confirm sympathetically mediated vasoconstriction is preserved or enhanced during hypoxaemia in young men, whereas peripheral vascular responsiveness to sympathetic activation during hypoxaemia is attenuated in young women. The results advance our understanding of sex‐related differences in hypoxic vascular control.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>34187092</pmid><doi>10.1113/EP089461</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9982-5851</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Blood flow Blood Pressure Female Forearm Forearm - blood supply forearm blood flow Humans Hypoxia Male Occlusion Peripheral blood Regional Blood Flow - physiology Sex Characteristics Sex differences Sympathetic nervous system Sympathetic Nervous System - physiology vascular resistance Vasoconstriction Vasoconstriction - physiology women Young adults |
| title | Sex differences in the vascular response to sympathetic activation during acute hypoxaemia |
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