Cytokine and epigenetic regulation of programmed death‐ligand 1 in stem cell differentiation and cancer cell plasticity

Programmed death‐ligand 1 (PD‐L1), an immune checkpoint ligand, is recognized as a potential target for cancer immunotherapy as well as for the induction of transplantation tolerance. However, how the crosstalk between stem cell programming and cytokine signaling regulates PD‐L1 expression during st...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2021-10, Vol.39 (10), p.1298-1309
Hauptverfasser:	Kuo, Ming‐Han, Chen, Pei‐Yu, Yang, Yi‐Ping, Zheng, Ming‐Yi, Miao, Chia‐Cheng, Wen, Kuo‐Chang, Chang, Kuo‐Ming, Chou, Shih‐Jie, Wang, Mong‐Lien, Chiou, Shih‐Hwa, Chou, Yu‐Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis B7-H1 Antigen - metabolism Cancer immunotherapy Cell activation Cell death Cell differentiation Cell Differentiation - genetics cell plasticity Cell Plasticity - genetics Crosstalk cytokine Cytokines Cytokines - metabolism differentiation Differentiation (biology) Epidermal growth factor receptors Epigenesis, Genetic Epigenetics ErbB Receptors - metabolism Fibroblasts Humans Immune checkpoint Immunological tolerance Immunotherapy Inhibitory postsynaptic potentials Ligands Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism PD-L1 protein PD‐L1 Plastic properties Plasticity Pluripotency Signaling SOX2 Stem cells Stem Cells - cytology Stimulation Transplantation
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