FBXO22, ubiquitination degradation of PHLPP1, ameliorates rotenone induced neurotoxicity by activating AKT pathway

•Reveal the role and related regulatory mechanism of FBXO22 in Parkinson's disease.•FBXO22 degraded PHLPP1 by ubiquitination to ameliorate rotenone induced neurotoxicity by activating AKT pathway.•Investigated the function of FBXO22/PHLPP1 axis on rotenone. Parkinson's disease (PD) is a ne...

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Veröffentlicht in:	Toxicology letters 2021-10, Vol.350, p.1-9
Hauptverfasser:	Zheng, Xiuqin, Yu, Suwen, Xue, Yang, Yan, Fuling
Format:	Artikel
Sprache:	eng
Schlagworte:	FBXO22 Neurotoxicity PHLPP1 Rotenone Ubiquitination
Online-Zugang:	Volltext
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