KLF4 Upregulation in Atherosclerotic Thoracic Aortas: Exploring the Protective Effect of Colchicine-based Regimens in a Hyperlipidemic Rabbit Model

•Rabbits were fed regular or hyperlipidemic diets ± colchicine-based regimens.•KLF4 was upregulated in the thoracic aortas of all hyperlipidemic groups.•Smaller plaques were found when combining NAC with colchicine instead of fibrate.•Less KLF4 upregulation was noted in the colchicine plus N-acetylc...

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Veröffentlicht in:	Annals of vascular surgery 2022-01, Vol.78, p.328-335
Hauptverfasser:	Mylonas, Konstantinos S., Kapelouzou, Alkistis, Spartalis, Michael, Mastrogeorgiou, Michael, Spartalis, Eletherios, Bakoyiannis, Christos, Liakakos, Theodoros, Schizas, Dimitrios, Iliopoulos, Dimitrios, Nikiteas, Nikolaos
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Anti-Inflammatory Agents - pharmacology Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Aortic Diseases - drug therapy Aortic Diseases - etiology Aortic Diseases - metabolism Aortic Diseases - pathology Atherosclerosis - drug therapy Atherosclerosis - etiology Atherosclerosis - metabolism Atherosclerosis - pathology Colchicine - pharmacology Disease Models, Animal Drug Therapy, Combination Fibric Acids - pharmacology Hyperlipidemias - complications Kruppel-Like Factor 4 - genetics Kruppel-Like Factor 4 - metabolism Male Plaque, Atherosclerotic Rabbits Up-Regulation
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