Histogram analysis of arterial spin labeling perfusion data to determine the human papillomavirus status of oropharyngeal squamous cell carcinomas
Purpose To evaluate the correlation between histogram parameters derived from pseudo-continuous arterial spin labeling (PCASL) and human papillomavirus (HPV) status in patients with oropharyngeal squamous cell carcinoma (OPSCC). Methods This study included a total of 58 patients (HPV-positive: n = 4...
Gespeichert in:
| Veröffentlicht in: | Neuroradiology 2021-08, Vol.63 (8), p.1345-1352 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1352 |
|---|---|
| container_issue | 8 |
| container_start_page | 1345 |
| container_title | Neuroradiology |
| container_volume | 63 |
| creator | Ahn, Yura Choi, Young Jun Sung, Yu Sub Pfeuffer, Josef Suh, Chong Hyun Chung, Sae Rom Baek, Jung Hwan Lee, Jeong Hyun |
| description | Purpose
To evaluate the correlation between histogram parameters derived from pseudo-continuous arterial spin labeling (PCASL) and human papillomavirus (HPV) status in patients with oropharyngeal squamous cell carcinoma (OPSCC).
Methods
This study included a total of 58 patients (HPV-positive: n = 45; -negative: n = 13) from a prospective cohort of consecutive patients aged ≥ 18 years, who were newly diagnosed with oropharyngeal squamous cell carcinoma. All patients were required to have undergone pre-treatment MRI with PCASL to measure regional perfusion. The region of interest was drawn by two radiologists, encompassing the entire tumor volume on all corresponding slices. Differences in the histogram parameters derived from tumor blood flow (TBF) in ASL were assessed for HPV-positive and -negative patients. Receiver operating characteristic curve analysis was performed to determine the best differentiating parameters, and a leave-one-out cross-validation was used.
Results
Patients with HPV-positive OPSCC showed a significantly lower overall standard deviation and 95th percentile value of tumor blood flow (P |
| doi_str_mv | 10.1007/s00234-021-02751-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2546600588</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2546600588</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-36b2e89fe310bd9c68c3455a612f4ab500321aadee596602d00a219a866639a3</originalsourceid><addsrcrecordid>eNp9kcGKFDEQhoMoOK6-gKeAFy-tlaSTSR9l0V1hwcveQ013eiZLOulNpYV9DZ_YzI4gePBQ1KG-_6eqfsbeC_gkAPafCUCqvgMpWu216MwLthO9kp0YJLxkuza3nRp6eM3eED0AgNqr_Y79ug1U87HgwjFhfKJAPM8cS_UlYOS0hsQjHnwM6chXX-aNQk58woq8Zj75Bi4heV5Pnp-2BRNfcQ0x5gV_hrIRp4p1e3bNJa8nLE_p6M_WjxsuuU1GHyMfsYwhNRG9Za9mjOTf_elX7P7b1_vr2-7ux8336y933dgLWztlDtLbYfZKwGEaRmNH1WuNRsi5x4NuF0qBOHmvB2NATgAoxYDWGKMGVFfs48V2Lflx81TdEui8CibftnJS900G2tqGfvgHfchbae86U1oZYa3VjZIXaiyZqPjZrSUs7VwnwJ1TcpeUXEvJPafkTBOpi4ga3P5S_lr_R_UbIj-X-Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2553618885</pqid></control><display><type>article</type><title>Histogram analysis of arterial spin labeling perfusion data to determine the human papillomavirus status of oropharyngeal squamous cell carcinomas</title><source>SpringerNature Journals</source><creator>Ahn, Yura ; Choi, Young Jun ; Sung, Yu Sub ; Pfeuffer, Josef ; Suh, Chong Hyun ; Chung, Sae Rom ; Baek, Jung Hwan ; Lee, Jeong Hyun</creator><creatorcontrib>Ahn, Yura ; Choi, Young Jun ; Sung, Yu Sub ; Pfeuffer, Josef ; Suh, Chong Hyun ; Chung, Sae Rom ; Baek, Jung Hwan ; Lee, Jeong Hyun</creatorcontrib><description>Purpose
To evaluate the correlation between histogram parameters derived from pseudo-continuous arterial spin labeling (PCASL) and human papillomavirus (HPV) status in patients with oropharyngeal squamous cell carcinoma (OPSCC).
Methods
This study included a total of 58 patients (HPV-positive: n = 45; -negative: n = 13) from a prospective cohort of consecutive patients aged ≥ 18 years, who were newly diagnosed with oropharyngeal squamous cell carcinoma. All patients were required to have undergone pre-treatment MRI with PCASL to measure regional perfusion. The region of interest was drawn by two radiologists, encompassing the entire tumor volume on all corresponding slices. Differences in the histogram parameters derived from tumor blood flow (TBF) in ASL were assessed for HPV-positive and -negative patients. Receiver operating characteristic curve analysis was performed to determine the best differentiating parameters, and a leave-one-out cross-validation was used.
Results
Patients with HPV-positive OPSCC showed a significantly lower overall standard deviation and 95th percentile value of tumor blood flow (P < .007). The standard deviation of TBF was the single best predictive parameter. Leave-one-out cross-validation tests revealed that the area under the receiver operating characteristic curve, accuracy, sensitivity, and specificity were 0.745, 75.9%, 75.6%, and 76.9%, respectively.
Conclusion
PCASL revealed differences in perfusion parameters according to HPV status in patients with OPSCC, reflecting their distinct histopathology.</description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-021-02751-6</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Blood flow ; Head-Neck-ENT Radiology ; Histograms ; Histopathology ; Human papillomavirus ; Imaging ; Labeling ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Oropharyngolaryngeal carcinoma ; Parameters ; Patients ; Perfusion ; Radiology ; Spin labeling ; Squamous cell carcinoma ; Standard deviation ; Throat cancer ; Tumors</subject><ispartof>Neuroradiology, 2021-08, Vol.63 (8), p.1345-1352</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-36b2e89fe310bd9c68c3455a612f4ab500321aadee596602d00a219a866639a3</citedby><cites>FETCH-LOGICAL-c418t-36b2e89fe310bd9c68c3455a612f4ab500321aadee596602d00a219a866639a3</cites><orcidid>0000-0001-7098-5042</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00234-021-02751-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00234-021-02751-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Ahn, Yura</creatorcontrib><creatorcontrib>Choi, Young Jun</creatorcontrib><creatorcontrib>Sung, Yu Sub</creatorcontrib><creatorcontrib>Pfeuffer, Josef</creatorcontrib><creatorcontrib>Suh, Chong Hyun</creatorcontrib><creatorcontrib>Chung, Sae Rom</creatorcontrib><creatorcontrib>Baek, Jung Hwan</creatorcontrib><creatorcontrib>Lee, Jeong Hyun</creatorcontrib><title>Histogram analysis of arterial spin labeling perfusion data to determine the human papillomavirus status of oropharyngeal squamous cell carcinomas</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><description>Purpose
To evaluate the correlation between histogram parameters derived from pseudo-continuous arterial spin labeling (PCASL) and human papillomavirus (HPV) status in patients with oropharyngeal squamous cell carcinoma (OPSCC).
Methods
This study included a total of 58 patients (HPV-positive: n = 45; -negative: n = 13) from a prospective cohort of consecutive patients aged ≥ 18 years, who were newly diagnosed with oropharyngeal squamous cell carcinoma. All patients were required to have undergone pre-treatment MRI with PCASL to measure regional perfusion. The region of interest was drawn by two radiologists, encompassing the entire tumor volume on all corresponding slices. Differences in the histogram parameters derived from tumor blood flow (TBF) in ASL were assessed for HPV-positive and -negative patients. Receiver operating characteristic curve analysis was performed to determine the best differentiating parameters, and a leave-one-out cross-validation was used.
Results
Patients with HPV-positive OPSCC showed a significantly lower overall standard deviation and 95th percentile value of tumor blood flow (P < .007). The standard deviation of TBF was the single best predictive parameter. Leave-one-out cross-validation tests revealed that the area under the receiver operating characteristic curve, accuracy, sensitivity, and specificity were 0.745, 75.9%, 75.6%, and 76.9%, respectively.
Conclusion
PCASL revealed differences in perfusion parameters according to HPV status in patients with OPSCC, reflecting their distinct histopathology.</description><subject>Blood flow</subject><subject>Head-Neck-ENT Radiology</subject><subject>Histograms</subject><subject>Histopathology</subject><subject>Human papillomavirus</subject><subject>Imaging</subject><subject>Labeling</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Oropharyngolaryngeal carcinoma</subject><subject>Parameters</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Radiology</subject><subject>Spin labeling</subject><subject>Squamous cell carcinoma</subject><subject>Standard deviation</subject><subject>Throat cancer</subject><subject>Tumors</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kcGKFDEQhoMoOK6-gKeAFy-tlaSTSR9l0V1hwcveQ013eiZLOulNpYV9DZ_YzI4gePBQ1KG-_6eqfsbeC_gkAPafCUCqvgMpWu216MwLthO9kp0YJLxkuza3nRp6eM3eED0AgNqr_Y79ug1U87HgwjFhfKJAPM8cS_UlYOS0hsQjHnwM6chXX-aNQk58woq8Zj75Bi4heV5Pnp-2BRNfcQ0x5gV_hrIRp4p1e3bNJa8nLE_p6M_WjxsuuU1GHyMfsYwhNRG9Za9mjOTf_elX7P7b1_vr2-7ux8336y933dgLWztlDtLbYfZKwGEaRmNH1WuNRsi5x4NuF0qBOHmvB2NATgAoxYDWGKMGVFfs48V2Lflx81TdEui8CibftnJS900G2tqGfvgHfchbae86U1oZYa3VjZIXaiyZqPjZrSUs7VwnwJ1TcpeUXEvJPafkTBOpi4ga3P5S_lr_R_UbIj-X-Q</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Ahn, Yura</creator><creator>Choi, Young Jun</creator><creator>Sung, Yu Sub</creator><creator>Pfeuffer, Josef</creator><creator>Suh, Chong Hyun</creator><creator>Chung, Sae Rom</creator><creator>Baek, Jung Hwan</creator><creator>Lee, Jeong Hyun</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7098-5042</orcidid></search><sort><creationdate>20210801</creationdate><title>Histogram analysis of arterial spin labeling perfusion data to determine the human papillomavirus status of oropharyngeal squamous cell carcinomas</title><author>Ahn, Yura ; Choi, Young Jun ; Sung, Yu Sub ; Pfeuffer, Josef ; Suh, Chong Hyun ; Chung, Sae Rom ; Baek, Jung Hwan ; Lee, Jeong Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-36b2e89fe310bd9c68c3455a612f4ab500321aadee596602d00a219a866639a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Blood flow</topic><topic>Head-Neck-ENT Radiology</topic><topic>Histograms</topic><topic>Histopathology</topic><topic>Human papillomavirus</topic><topic>Imaging</topic><topic>Labeling</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Oropharyngolaryngeal carcinoma</topic><topic>Parameters</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Radiology</topic><topic>Spin labeling</topic><topic>Squamous cell carcinoma</topic><topic>Standard deviation</topic><topic>Throat cancer</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Yura</creatorcontrib><creatorcontrib>Choi, Young Jun</creatorcontrib><creatorcontrib>Sung, Yu Sub</creatorcontrib><creatorcontrib>Pfeuffer, Josef</creatorcontrib><creatorcontrib>Suh, Chong Hyun</creatorcontrib><creatorcontrib>Chung, Sae Rom</creatorcontrib><creatorcontrib>Baek, Jung Hwan</creatorcontrib><creatorcontrib>Lee, Jeong Hyun</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Yura</au><au>Choi, Young Jun</au><au>Sung, Yu Sub</au><au>Pfeuffer, Josef</au><au>Suh, Chong Hyun</au><au>Chung, Sae Rom</au><au>Baek, Jung Hwan</au><au>Lee, Jeong Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histogram analysis of arterial spin labeling perfusion data to determine the human papillomavirus status of oropharyngeal squamous cell carcinomas</atitle><jtitle>Neuroradiology</jtitle><stitle>Neuroradiology</stitle><date>2021-08-01</date><risdate>2021</risdate><volume>63</volume><issue>8</issue><spage>1345</spage><epage>1352</epage><pages>1345-1352</pages><issn>0028-3940</issn><eissn>1432-1920</eissn><abstract>Purpose
To evaluate the correlation between histogram parameters derived from pseudo-continuous arterial spin labeling (PCASL) and human papillomavirus (HPV) status in patients with oropharyngeal squamous cell carcinoma (OPSCC).
Methods
This study included a total of 58 patients (HPV-positive: n = 45; -negative: n = 13) from a prospective cohort of consecutive patients aged ≥ 18 years, who were newly diagnosed with oropharyngeal squamous cell carcinoma. All patients were required to have undergone pre-treatment MRI with PCASL to measure regional perfusion. The region of interest was drawn by two radiologists, encompassing the entire tumor volume on all corresponding slices. Differences in the histogram parameters derived from tumor blood flow (TBF) in ASL were assessed for HPV-positive and -negative patients. Receiver operating characteristic curve analysis was performed to determine the best differentiating parameters, and a leave-one-out cross-validation was used.
Results
Patients with HPV-positive OPSCC showed a significantly lower overall standard deviation and 95th percentile value of tumor blood flow (P < .007). The standard deviation of TBF was the single best predictive parameter. Leave-one-out cross-validation tests revealed that the area under the receiver operating characteristic curve, accuracy, sensitivity, and specificity were 0.745, 75.9%, 75.6%, and 76.9%, respectively.
Conclusion
PCASL revealed differences in perfusion parameters according to HPV status in patients with OPSCC, reflecting their distinct histopathology.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00234-021-02751-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7098-5042</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3940 |
| ispartof | Neuroradiology, 2021-08, Vol.63 (8), p.1345-1352 |
| issn | 0028-3940 1432-1920 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2546600588 |
| source | SpringerNature Journals |
| subjects | Blood flow Head-Neck-ENT Radiology Histograms Histopathology Human papillomavirus Imaging Labeling Magnetic resonance imaging Medicine Medicine & Public Health Neurology Neuroradiology Neurosciences Neurosurgery Oropharyngolaryngeal carcinoma Parameters Patients Perfusion Radiology Spin labeling Squamous cell carcinoma Standard deviation Throat cancer Tumors |
| title | Histogram analysis of arterial spin labeling perfusion data to determine the human papillomavirus status of oropharyngeal squamous cell carcinomas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T14%3A22%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Histogram%20analysis%20of%20arterial%20spin%20labeling%20perfusion%20data%20to%20determine%20the%20human%20papillomavirus%20status%20of%20oropharyngeal%20squamous%20cell%20carcinomas&rft.jtitle=Neuroradiology&rft.au=Ahn,%20Yura&rft.date=2021-08-01&rft.volume=63&rft.issue=8&rft.spage=1345&rft.epage=1352&rft.pages=1345-1352&rft.issn=0028-3940&rft.eissn=1432-1920&rft_id=info:doi/10.1007/s00234-021-02751-6&rft_dat=%3Cproquest_cross%3E2546600588%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2553618885&rft_id=info:pmid/&rfr_iscdi=true |