Preparation of a polydopamine/β‐cyclodextrin coated open tubular capillary electrochromatography column and application for enantioseparation of five proton pump inhibitors
An open tubular capillary electrochromatography column was prepared by immobilizing β‐cyclodextrin on the inner wall of pretreated capillary via noncovalent adsorption of polydopamine. The resulting coating layer on the capillary was characterized by scanning electron microscopy and Fourier transfor...
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| Veröffentlicht in: | Journal of separation science 2021-09, Vol.44 (17), p.3295-3304 |
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| creator | Sui, Xiuyu Guan, Jin Li, Xiaoyu Gu, Lei Yan, Feng Shi, Shuang Zhang, Dongxiang |
| description | An open tubular capillary electrochromatography column was prepared by immobilizing β‐cyclodextrin on the inner wall of pretreated capillary via noncovalent adsorption of polydopamine. The resulting coating layer on the capillary was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. Electroosmotic flow was studied to evaluate the variation of the immobilized columns. The prepared columns showed good chiral separation performance toward five proton pump inhibitors including lansoprazole, pantoprazole, tenatoprazole, rabeprazole, and omeprazole. The influences of β‐cyclodextrin concentration, coating time, buffer pH, buffer concentration, and applied voltage on separation were investigated. In the optimum conditions, the enantiomers of five analytes were fully resolved within 15 min with high resolutions of 4.57 to 8.13. The method was extensively validated in terms of accuracy, precision, and linearity and proved to be robust. The relative standard deviation values for migration times and peak areas of the analytes representing intraday and interday were less than 1.9 and 3.6%, respectively. Further, the polydopamine/β‐cyclodextrin coated capillary column could be successively used over 100 runs without showing significant decrease in the separation efficiency. |
| doi_str_mv | 10.1002/jssc.202100298 |
| format | Article |
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The resulting coating layer on the capillary was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. Electroosmotic flow was studied to evaluate the variation of the immobilized columns. The prepared columns showed good chiral separation performance toward five proton pump inhibitors including lansoprazole, pantoprazole, tenatoprazole, rabeprazole, and omeprazole. The influences of β‐cyclodextrin concentration, coating time, buffer pH, buffer concentration, and applied voltage on separation were investigated. In the optimum conditions, the enantiomers of five analytes were fully resolved within 15 min with high resolutions of 4.57 to 8.13. The method was extensively validated in terms of accuracy, precision, and linearity and proved to be robust. The relative standard deviation values for migration times and peak areas of the analytes representing intraday and interday were less than 1.9 and 3.6%, respectively. Further, the polydopamine/β‐cyclodextrin coated capillary column could be successively used over 100 runs without showing significant decrease in the separation efficiency.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.202100298</identifier><identifier>PMID: 34185396</identifier><language>eng</language><publisher>WEINHEIM: Wiley</publisher><subject>beta-Cyclodextrins - analysis ; beta-Cyclodextrins - chemical synthesis ; Buffers ; Capillary Electrochromatography ; Chemistry ; Chemistry, Analytical ; Chiral separation ; Cyclodextrins ; Electrochromatography ; Electroosmosis ; Enantiomers ; Fourier transforms ; Indoles - analysis ; Indoles - chemical synthesis ; Inhibitors ; Molecular Structure ; Open tubular capillary electrochromatography ; Physical Sciences ; Polydopamine ; Polymers - analysis ; Polymers - chemical synthesis ; Proton pump inhibitors ; Proton Pump Inhibitors - analysis ; Proton Pump Inhibitors - chemical synthesis ; Protons ; Science & Technology ; Separation ; Stereoisomerism</subject><ispartof>Journal of separation science, 2021-09, Vol.44 (17), p.3295-3304</ispartof><rights>2021 Wiley‐VCH GmbH</rights><rights>2021 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>10</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000671746800001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3685-451b31b4680aeadab54f6f1f31222812e5fabb4448264d226180a78e39a4e63a3</citedby><cites>FETCH-LOGICAL-c3685-451b31b4680aeadab54f6f1f31222812e5fabb4448264d226180a78e39a4e63a3</cites><orcidid>0000-0002-4270-7835</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.202100298$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.202100298$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34185396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sui, Xiuyu</creatorcontrib><creatorcontrib>Guan, Jin</creatorcontrib><creatorcontrib>Li, Xiaoyu</creatorcontrib><creatorcontrib>Gu, Lei</creatorcontrib><creatorcontrib>Yan, Feng</creatorcontrib><creatorcontrib>Shi, Shuang</creatorcontrib><creatorcontrib>Zhang, Dongxiang</creatorcontrib><title>Preparation of a polydopamine/β‐cyclodextrin coated open tubular capillary electrochromatography column and application for enantioseparation of five proton pump inhibitors</title><title>Journal of separation science</title><addtitle>J SEP SCI</addtitle><addtitle>J Sep Sci</addtitle><description>An open tubular capillary electrochromatography column was prepared by immobilizing β‐cyclodextrin on the inner wall of pretreated capillary via noncovalent adsorption of polydopamine. The resulting coating layer on the capillary was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. Electroosmotic flow was studied to evaluate the variation of the immobilized columns. The prepared columns showed good chiral separation performance toward five proton pump inhibitors including lansoprazole, pantoprazole, tenatoprazole, rabeprazole, and omeprazole. The influences of β‐cyclodextrin concentration, coating time, buffer pH, buffer concentration, and applied voltage on separation were investigated. In the optimum conditions, the enantiomers of five analytes were fully resolved within 15 min with high resolutions of 4.57 to 8.13. The method was extensively validated in terms of accuracy, precision, and linearity and proved to be robust. The relative standard deviation values for migration times and peak areas of the analytes representing intraday and interday were less than 1.9 and 3.6%, respectively. Further, the polydopamine/β‐cyclodextrin coated capillary column could be successively used over 100 runs without showing significant decrease in the separation efficiency.</description><subject>beta-Cyclodextrins - analysis</subject><subject>beta-Cyclodextrins - chemical synthesis</subject><subject>Buffers</subject><subject>Capillary Electrochromatography</subject><subject>Chemistry</subject><subject>Chemistry, Analytical</subject><subject>Chiral separation</subject><subject>Cyclodextrins</subject><subject>Electrochromatography</subject><subject>Electroosmosis</subject><subject>Enantiomers</subject><subject>Fourier transforms</subject><subject>Indoles - analysis</subject><subject>Indoles - chemical synthesis</subject><subject>Inhibitors</subject><subject>Molecular Structure</subject><subject>Open tubular capillary electrochromatography</subject><subject>Physical Sciences</subject><subject>Polydopamine</subject><subject>Polymers - analysis</subject><subject>Polymers - chemical synthesis</subject><subject>Proton pump inhibitors</subject><subject>Proton Pump Inhibitors - analysis</subject><subject>Proton Pump Inhibitors - chemical synthesis</subject><subject>Protons</subject><subject>Science & Technology</subject><subject>Separation</subject><subject>Stereoisomerism</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc2KFDEUhQtRnHF061ICbgTpnvxXaimNjsqAwui6SKVu2WmqkpikRnvnI8ybCD6ID-GTmLbbBt1oNrkXvnNzck9VPSR4STCm55uUzJJiumsadas6JZKIRcMIv32ssTyp7qW0wZjUqsF3qxPGiRKskafV17cRgo46W--QH5BGwY_b3gc9WQfn37_9-HJjtmb0PXzO0TpkvM7QIx_AoTx386gjMjrYsRRbBCOYHL1ZRz_p7D9EHdbbohnnySHteqRDGK3ZPzf4iMBpV5r0h4nBXgMK0efShnkKyLq17Wz2Md2v7gx6TPDgcJ9V7188f7d6ubh8c_Fq9exyYZhUYsEF6RjpuFRYg-51J_ggBzIwQilVhIIYdNdxzhWVvKdUkgLWClijOUim2Vn1ZD-32Pg4Q8rtZJOB8ksHfk4tFVyKRtVEFfTxX-jGz9EVd4WSDRNYcVGo5Z4y0acUYWhDtFPZWUtwu0uv3UXZHqMsgkeHsXM3QX_Ef2dXgKd74BN0fkjGgjNwxDDGsib1bgPlkEKr_6dXNv8KY-Vnl4uUH6R2hO0_fLevr65WNWOC_QQC9tFz</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Sui, Xiuyu</creator><creator>Guan, Jin</creator><creator>Li, Xiaoyu</creator><creator>Gu, Lei</creator><creator>Yan, Feng</creator><creator>Shi, Shuang</creator><creator>Zhang, Dongxiang</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4270-7835</orcidid></search><sort><creationdate>202109</creationdate><title>Preparation of a polydopamine/β‐cyclodextrin coated open tubular capillary electrochromatography column and application for enantioseparation of five proton pump inhibitors</title><author>Sui, Xiuyu ; Guan, Jin ; Li, Xiaoyu ; Gu, Lei ; Yan, Feng ; Shi, Shuang ; Zhang, Dongxiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3685-451b31b4680aeadab54f6f1f31222812e5fabb4448264d226180a78e39a4e63a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>beta-Cyclodextrins - analysis</topic><topic>beta-Cyclodextrins - chemical synthesis</topic><topic>Buffers</topic><topic>Capillary Electrochromatography</topic><topic>Chemistry</topic><topic>Chemistry, Analytical</topic><topic>Chiral separation</topic><topic>Cyclodextrins</topic><topic>Electrochromatography</topic><topic>Electroosmosis</topic><topic>Enantiomers</topic><topic>Fourier transforms</topic><topic>Indoles - analysis</topic><topic>Indoles - chemical synthesis</topic><topic>Inhibitors</topic><topic>Molecular Structure</topic><topic>Open tubular capillary electrochromatography</topic><topic>Physical Sciences</topic><topic>Polydopamine</topic><topic>Polymers - analysis</topic><topic>Polymers - chemical synthesis</topic><topic>Proton pump inhibitors</topic><topic>Proton Pump Inhibitors - analysis</topic><topic>Proton Pump Inhibitors - chemical synthesis</topic><topic>Protons</topic><topic>Science & Technology</topic><topic>Separation</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sui, Xiuyu</creatorcontrib><creatorcontrib>Guan, Jin</creatorcontrib><creatorcontrib>Li, Xiaoyu</creatorcontrib><creatorcontrib>Gu, Lei</creatorcontrib><creatorcontrib>Yan, Feng</creatorcontrib><creatorcontrib>Shi, Shuang</creatorcontrib><creatorcontrib>Zhang, Dongxiang</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sui, Xiuyu</au><au>Guan, Jin</au><au>Li, Xiaoyu</au><au>Gu, Lei</au><au>Yan, Feng</au><au>Shi, Shuang</au><au>Zhang, Dongxiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of a polydopamine/β‐cyclodextrin coated open tubular capillary electrochromatography column and application for enantioseparation of five proton pump inhibitors</atitle><jtitle>Journal of separation science</jtitle><stitle>J SEP SCI</stitle><addtitle>J Sep Sci</addtitle><date>2021-09</date><risdate>2021</risdate><volume>44</volume><issue>17</issue><spage>3295</spage><epage>3304</epage><pages>3295-3304</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>An open tubular capillary electrochromatography column was prepared by immobilizing β‐cyclodextrin on the inner wall of pretreated capillary via noncovalent adsorption of polydopamine. The resulting coating layer on the capillary was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. Electroosmotic flow was studied to evaluate the variation of the immobilized columns. The prepared columns showed good chiral separation performance toward five proton pump inhibitors including lansoprazole, pantoprazole, tenatoprazole, rabeprazole, and omeprazole. The influences of β‐cyclodextrin concentration, coating time, buffer pH, buffer concentration, and applied voltage on separation were investigated. In the optimum conditions, the enantiomers of five analytes were fully resolved within 15 min with high resolutions of 4.57 to 8.13. The method was extensively validated in terms of accuracy, precision, and linearity and proved to be robust. The relative standard deviation values for migration times and peak areas of the analytes representing intraday and interday were less than 1.9 and 3.6%, respectively. Further, the polydopamine/β‐cyclodextrin coated capillary column could be successively used over 100 runs without showing significant decrease in the separation efficiency.</abstract><cop>WEINHEIM</cop><pub>Wiley</pub><pmid>34185396</pmid><doi>10.1002/jssc.202100298</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4270-7835</orcidid></addata></record> |
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| subjects | beta-Cyclodextrins - analysis beta-Cyclodextrins - chemical synthesis Buffers Capillary Electrochromatography Chemistry Chemistry, Analytical Chiral separation Cyclodextrins Electrochromatography Electroosmosis Enantiomers Fourier transforms Indoles - analysis Indoles - chemical synthesis Inhibitors Molecular Structure Open tubular capillary electrochromatography Physical Sciences Polydopamine Polymers - analysis Polymers - chemical synthesis Proton pump inhibitors Proton Pump Inhibitors - analysis Proton Pump Inhibitors - chemical synthesis Protons Science & Technology Separation Stereoisomerism |
| title | Preparation of a polydopamine/β‐cyclodextrin coated open tubular capillary electrochromatography column and application for enantioseparation of five proton pump inhibitors |
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