Genome‐wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals

Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are biomarkers for liver health. Here we report the largest genome‐wide association analysis to date of serum ALT and AST levels in over 388k people of European ancestry from UK biobank and DiscovEHR. Eleven million imputed ma...

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Veröffentlicht in:	Genetic epidemiology 2021-09, Vol.45 (6), p.664-681
Hauptverfasser:	Gao, Chuan, Marcketta, Anthony, Backman, Joshua D., O'Dushlaine, Colm, Staples, Jeffrey, Ferreira, Manuel Allen Revez, Lotta, Luca A., Overton, John D., Reid, Jeffrey G., Mirshahi, Tooraj, Regeneron Genetics Center, Geisinger Regeneron Discovehr Collaboration, Baras, Aris, Abecasis, Gonçalo, Shuldiner, Alan R., Van Hout, Cristopher V., McCarthy, Shane
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Alanine Alanine transaminase Alanine Transaminase - blood ALT Aspartate aminotransferase Aspartate Aminotransferases - blood Association analysis AST Body Mass Index Etiology Gene frequency Genetics & Heredity Genome-Wide Association Study Genomes GWAS Humans interaction Life Sciences & Biomedicine liver disease Liver diseases Mathematical & Computational Biology Science & Technology Therapeutic targets
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