Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin

Background: Leptin-deficient ob/ob mice and leptin receptor-deficient db/db mice are commonly used mice models mimicking the conditions of obesity and type 2 diabetes development. However, although ob/ob and db/db mice are similarly gaining weight and developing massive obesity, db/db mice are more...

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