Familial aggregation of juvenile idiopathic arthritis with other autoimmune diseases: Impact on clinical characteristics, disease activity status and disease damage
Objectives To evaluate the impact of family history of autoimmune diseases (FHADs) on the clinical characteristics and outcome of juvenile idiopathic arthritis (JIA). Methods We retrospectively reviewed children with JIA seen in 7 pediatric rheumatology clinics from 6 Arab countries. All included pa...
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| Veröffentlicht in: | International journal of rheumatic diseases 2021-08, Vol.24 (8), p.1080-1085 |
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| creator | Al‐Mayouf, Sulaiman M. Alrasheedi, Abeer Almsellati, Iman Hashad, Soad Khawaja, Khulood Abdwani, Reem AlHashim, Samia Muzaffer, Mohammed Lotfy, Hala Almutairi, Nora |
| description | Objectives
To evaluate the impact of family history of autoimmune diseases (FHADs) on the clinical characteristics and outcome of juvenile idiopathic arthritis (JIA).
Methods
We retrospectively reviewed children with JIA seen in 7 pediatric rheumatology clinics from 6 Arab countries. All included patients met the International League of Associations for Rheumatology classification criteria for JIA and had a disease duration greater than 1 year. Data were collected at the last follow‐up visit and comprised clinical findings, including FHADs. Disease activity and disease damage were assessed by Juvenile Arthritis Multidimensional Assessment Report, and juvenile arthritis damage index (JADI) respectively. Disease activity was categorized as remission off treatment, remission on treatment, or active disease.
Results
A total of 349 (224 females) JIA patients with a disease duration of 5 (interquartile range 2.9‐7.5) years were included. The most frequent JIA categories were polyarticular JIA and oligoarticular JIA, followed by systemic JIA. There were 189 patients with FHADs and 160 patients without FHADs. The most frequent FHADs were diabetes mellitus (21.2%), JIA (18.5%), rheumatoid arthritis (12.7%). Among patients with FHADs, 140/189 (74.1%) achieved clinical remission, while 131/160 (81.9%) patients without FHDs had clinical remission (odds ratio [OR] = 1.2, 95% CI 0.97‐1.5). Rate of consanguinity, enthesitis‐related arthritis (ERA) and psoriatic arthritis were higher in patients with FHADs (OR = 0.6, 95% CI 0.4‐0.9 and OR = 1.2, 95% CI 1.1‐1.4). Also, articular JADI correlated significantly with presence of FHADs (OR = 1.1, 95% CI 1.0‐1.1).
Conclusion
This study shows that autoimmune diseases cluster within families of patients with JIA with a high proportion of ERA and psoriatic arthritis. JIA patients with FHADs are likely to have more disease damage. |
| doi_str_mv | 10.1111/1756-185X.14167 |
| format | Article |
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To evaluate the impact of family history of autoimmune diseases (FHADs) on the clinical characteristics and outcome of juvenile idiopathic arthritis (JIA).
Methods
We retrospectively reviewed children with JIA seen in 7 pediatric rheumatology clinics from 6 Arab countries. All included patients met the International League of Associations for Rheumatology classification criteria for JIA and had a disease duration greater than 1 year. Data were collected at the last follow‐up visit and comprised clinical findings, including FHADs. Disease activity and disease damage were assessed by Juvenile Arthritis Multidimensional Assessment Report, and juvenile arthritis damage index (JADI) respectively. Disease activity was categorized as remission off treatment, remission on treatment, or active disease.
Results
A total of 349 (224 females) JIA patients with a disease duration of 5 (interquartile range 2.9‐7.5) years were included. The most frequent JIA categories were polyarticular JIA and oligoarticular JIA, followed by systemic JIA. There were 189 patients with FHADs and 160 patients without FHADs. The most frequent FHADs were diabetes mellitus (21.2%), JIA (18.5%), rheumatoid arthritis (12.7%). Among patients with FHADs, 140/189 (74.1%) achieved clinical remission, while 131/160 (81.9%) patients without FHDs had clinical remission (odds ratio [OR] = 1.2, 95% CI 0.97‐1.5). Rate of consanguinity, enthesitis‐related arthritis (ERA) and psoriatic arthritis were higher in patients with FHADs (OR = 0.6, 95% CI 0.4‐0.9 and OR = 1.2, 95% CI 1.1‐1.4). Also, articular JADI correlated significantly with presence of FHADs (OR = 1.1, 95% CI 1.0‐1.1).
Conclusion
This study shows that autoimmune diseases cluster within families of patients with JIA with a high proportion of ERA and psoriatic arthritis. JIA patients with FHADs are likely to have more disease damage.</description><identifier>ISSN: 1756-1841</identifier><identifier>EISSN: 1756-185X</identifier><identifier>DOI: 10.1111/1756-185X.14167</identifier><identifier>PMID: 34184820</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Arthritis ; Arthritis, Juvenile - diagnosis ; Arthritis, Juvenile - drug therapy ; Arthritis, Juvenile - genetics ; Arthritis, Juvenile - immunology ; Autoimmune diseases ; Autoimmune Diseases - diagnosis ; Autoimmune Diseases - drug therapy ; Autoimmune Diseases - genetics ; Autoimmune Diseases - immunology ; Autoimmunity - genetics ; Child ; Child, Preschool ; Consanguinity ; Diabetes mellitus ; Disease ; familial arthritis ; familial autoimmune diseases ; Female ; Genetic Predisposition to Disease ; Heredity ; Humans ; juvenile arthritis damage index ; juvenile arthritis disease activity score ; juvenile idiopathic arthritis ; Male ; Middle East ; Patients ; Pediatrics ; Pedigree ; Prognosis ; Psoriatic arthritis ; Remission ; Remission (Medicine) ; Retrospective Studies ; Rheumatoid arthritis ; Rheumatology ; Risk Assessment ; Risk Factors</subject><ispartof>International journal of rheumatic diseases, 2021-08, Vol.24 (8), p.1080-1085</ispartof><rights>2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.</rights><rights>International Journal of Rheumatic Diseases © 2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3717-9dbaf65ecd9ff612e3573350da2b0d889b51898be11bf371d409c0e8423fb1593</citedby><cites>FETCH-LOGICAL-c3717-9dbaf65ecd9ff612e3573350da2b0d889b51898be11bf371d409c0e8423fb1593</cites><orcidid>0000-0003-0142-6698</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1756-185X.14167$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1756-185X.14167$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34184820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al‐Mayouf, Sulaiman M.</creatorcontrib><creatorcontrib>Alrasheedi, Abeer</creatorcontrib><creatorcontrib>Almsellati, Iman</creatorcontrib><creatorcontrib>Hashad, Soad</creatorcontrib><creatorcontrib>Khawaja, Khulood</creatorcontrib><creatorcontrib>Abdwani, Reem</creatorcontrib><creatorcontrib>AlHashim, Samia</creatorcontrib><creatorcontrib>Muzaffer, Mohammed</creatorcontrib><creatorcontrib>Lotfy, Hala</creatorcontrib><creatorcontrib>Almutairi, Nora</creatorcontrib><title>Familial aggregation of juvenile idiopathic arthritis with other autoimmune diseases: Impact on clinical characteristics, disease activity status and disease damage</title><title>International journal of rheumatic diseases</title><addtitle>Int J Rheum Dis</addtitle><description>Objectives
To evaluate the impact of family history of autoimmune diseases (FHADs) on the clinical characteristics and outcome of juvenile idiopathic arthritis (JIA).
Methods
We retrospectively reviewed children with JIA seen in 7 pediatric rheumatology clinics from 6 Arab countries. All included patients met the International League of Associations for Rheumatology classification criteria for JIA and had a disease duration greater than 1 year. Data were collected at the last follow‐up visit and comprised clinical findings, including FHADs. Disease activity and disease damage were assessed by Juvenile Arthritis Multidimensional Assessment Report, and juvenile arthritis damage index (JADI) respectively. Disease activity was categorized as remission off treatment, remission on treatment, or active disease.
Results
A total of 349 (224 females) JIA patients with a disease duration of 5 (interquartile range 2.9‐7.5) years were included. The most frequent JIA categories were polyarticular JIA and oligoarticular JIA, followed by systemic JIA. There were 189 patients with FHADs and 160 patients without FHADs. The most frequent FHADs were diabetes mellitus (21.2%), JIA (18.5%), rheumatoid arthritis (12.7%). Among patients with FHADs, 140/189 (74.1%) achieved clinical remission, while 131/160 (81.9%) patients without FHDs had clinical remission (odds ratio [OR] = 1.2, 95% CI 0.97‐1.5). Rate of consanguinity, enthesitis‐related arthritis (ERA) and psoriatic arthritis were higher in patients with FHADs (OR = 0.6, 95% CI 0.4‐0.9 and OR = 1.2, 95% CI 1.1‐1.4). Also, articular JADI correlated significantly with presence of FHADs (OR = 1.1, 95% CI 1.0‐1.1).
Conclusion
This study shows that autoimmune diseases cluster within families of patients with JIA with a high proportion of ERA and psoriatic arthritis. JIA patients with FHADs are likely to have more disease damage.</description><subject>Arthritis</subject><subject>Arthritis, Juvenile - diagnosis</subject><subject>Arthritis, Juvenile - drug therapy</subject><subject>Arthritis, Juvenile - genetics</subject><subject>Arthritis, Juvenile - immunology</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>Autoimmune Diseases - genetics</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmunity - genetics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Consanguinity</subject><subject>Diabetes mellitus</subject><subject>Disease</subject><subject>familial arthritis</subject><subject>familial autoimmune diseases</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Heredity</subject><subject>Humans</subject><subject>juvenile arthritis damage index</subject><subject>juvenile arthritis disease activity score</subject><subject>juvenile idiopathic arthritis</subject><subject>Male</subject><subject>Middle East</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Pedigree</subject><subject>Prognosis</subject><subject>Psoriatic arthritis</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Retrospective Studies</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>1756-1841</issn><issn>1756-185X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpaNK0596KoJccuolkW7LdWwhNE1hIDi30JsbSeD2LP7aSnLD_pz-02m6yh1yii8SrZ14GHsY-SXEu07mQpdILWanf57KQunzDTg7J28O7kMfsfQhrIbTMdfmOHedFSqtMnLC_1zBQT9BzWK08riDSNPKp5ev5AUfqkZOjaQOxI8vBx85TpMAfKXZ8ih16DnOcaBjmEbmjgBAwfOO3wwZs5KnK9jSSTf22A58y9BQi2fD1meYppAeKWx4ixDlwGN3hz8EAK_zAjlroA358uk_Zr-vvP69uFsu7H7dXl8uFzUtZLmrXQKsVWle3rZYZ5qrMcyUcZI1wVVU3SlZ11aCUTZsmXCFqK7AqsrxtpKrzU3a279346c-MIZqBgsW-hxGnOZhMFVrVpc526JcX6Hqa_Zi2S5Qqa5lVuU7UxZ6yfgrBY2s2ngbwWyOF2Qk0O0Vmp8v8F5gmPj_1zs2A7sA_G0uA2gOPSc72tT5zeb_cF_8DbIqo6w</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Al‐Mayouf, Sulaiman M.</creator><creator>Alrasheedi, Abeer</creator><creator>Almsellati, Iman</creator><creator>Hashad, Soad</creator><creator>Khawaja, Khulood</creator><creator>Abdwani, Reem</creator><creator>AlHashim, Samia</creator><creator>Muzaffer, Mohammed</creator><creator>Lotfy, Hala</creator><creator>Almutairi, Nora</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0142-6698</orcidid></search><sort><creationdate>202108</creationdate><title>Familial aggregation of juvenile idiopathic arthritis with other autoimmune diseases: Impact on clinical characteristics, disease activity status and disease damage</title><author>Al‐Mayouf, Sulaiman M. ; Alrasheedi, Abeer ; Almsellati, Iman ; Hashad, Soad ; Khawaja, Khulood ; Abdwani, Reem ; AlHashim, Samia ; Muzaffer, Mohammed ; Lotfy, Hala ; Almutairi, Nora</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3717-9dbaf65ecd9ff612e3573350da2b0d889b51898be11bf371d409c0e8423fb1593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Arthritis</topic><topic>Arthritis, Juvenile - diagnosis</topic><topic>Arthritis, Juvenile - drug therapy</topic><topic>Arthritis, Juvenile - genetics</topic><topic>Arthritis, Juvenile - immunology</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - diagnosis</topic><topic>Autoimmune Diseases - drug therapy</topic><topic>Autoimmune Diseases - genetics</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmunity - genetics</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Consanguinity</topic><topic>Diabetes mellitus</topic><topic>Disease</topic><topic>familial arthritis</topic><topic>familial autoimmune diseases</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Heredity</topic><topic>Humans</topic><topic>juvenile arthritis damage index</topic><topic>juvenile arthritis disease activity score</topic><topic>juvenile idiopathic arthritis</topic><topic>Male</topic><topic>Middle East</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Pedigree</topic><topic>Prognosis</topic><topic>Psoriatic arthritis</topic><topic>Remission</topic><topic>Remission (Medicine)</topic><topic>Retrospective Studies</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al‐Mayouf, Sulaiman M.</creatorcontrib><creatorcontrib>Alrasheedi, Abeer</creatorcontrib><creatorcontrib>Almsellati, Iman</creatorcontrib><creatorcontrib>Hashad, Soad</creatorcontrib><creatorcontrib>Khawaja, Khulood</creatorcontrib><creatorcontrib>Abdwani, Reem</creatorcontrib><creatorcontrib>AlHashim, Samia</creatorcontrib><creatorcontrib>Muzaffer, Mohammed</creatorcontrib><creatorcontrib>Lotfy, Hala</creatorcontrib><creatorcontrib>Almutairi, Nora</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al‐Mayouf, Sulaiman M.</au><au>Alrasheedi, Abeer</au><au>Almsellati, Iman</au><au>Hashad, Soad</au><au>Khawaja, Khulood</au><au>Abdwani, Reem</au><au>AlHashim, Samia</au><au>Muzaffer, Mohammed</au><au>Lotfy, Hala</au><au>Almutairi, Nora</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Familial aggregation of juvenile idiopathic arthritis with other autoimmune diseases: Impact on clinical characteristics, disease activity status and disease damage</atitle><jtitle>International journal of rheumatic diseases</jtitle><addtitle>Int J Rheum Dis</addtitle><date>2021-08</date><risdate>2021</risdate><volume>24</volume><issue>8</issue><spage>1080</spage><epage>1085</epage><pages>1080-1085</pages><issn>1756-1841</issn><eissn>1756-185X</eissn><abstract>Objectives
To evaluate the impact of family history of autoimmune diseases (FHADs) on the clinical characteristics and outcome of juvenile idiopathic arthritis (JIA).
Methods
We retrospectively reviewed children with JIA seen in 7 pediatric rheumatology clinics from 6 Arab countries. All included patients met the International League of Associations for Rheumatology classification criteria for JIA and had a disease duration greater than 1 year. Data were collected at the last follow‐up visit and comprised clinical findings, including FHADs. Disease activity and disease damage were assessed by Juvenile Arthritis Multidimensional Assessment Report, and juvenile arthritis damage index (JADI) respectively. Disease activity was categorized as remission off treatment, remission on treatment, or active disease.
Results
A total of 349 (224 females) JIA patients with a disease duration of 5 (interquartile range 2.9‐7.5) years were included. The most frequent JIA categories were polyarticular JIA and oligoarticular JIA, followed by systemic JIA. There were 189 patients with FHADs and 160 patients without FHADs. The most frequent FHADs were diabetes mellitus (21.2%), JIA (18.5%), rheumatoid arthritis (12.7%). Among patients with FHADs, 140/189 (74.1%) achieved clinical remission, while 131/160 (81.9%) patients without FHDs had clinical remission (odds ratio [OR] = 1.2, 95% CI 0.97‐1.5). Rate of consanguinity, enthesitis‐related arthritis (ERA) and psoriatic arthritis were higher in patients with FHADs (OR = 0.6, 95% CI 0.4‐0.9 and OR = 1.2, 95% CI 1.1‐1.4). Also, articular JADI correlated significantly with presence of FHADs (OR = 1.1, 95% CI 1.0‐1.1).
Conclusion
This study shows that autoimmune diseases cluster within families of patients with JIA with a high proportion of ERA and psoriatic arthritis. JIA patients with FHADs are likely to have more disease damage.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34184820</pmid><doi>10.1111/1756-185X.14167</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0142-6698</orcidid></addata></record> |
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| subjects | Arthritis Arthritis, Juvenile - diagnosis Arthritis, Juvenile - drug therapy Arthritis, Juvenile - genetics Arthritis, Juvenile - immunology Autoimmune diseases Autoimmune Diseases - diagnosis Autoimmune Diseases - drug therapy Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmunity - genetics Child Child, Preschool Consanguinity Diabetes mellitus Disease familial arthritis familial autoimmune diseases Female Genetic Predisposition to Disease Heredity Humans juvenile arthritis damage index juvenile arthritis disease activity score juvenile idiopathic arthritis Male Middle East Patients Pediatrics Pedigree Prognosis Psoriatic arthritis Remission Remission (Medicine) Retrospective Studies Rheumatoid arthritis Rheumatology Risk Assessment Risk Factors |
| title | Familial aggregation of juvenile idiopathic arthritis with other autoimmune diseases: Impact on clinical characteristics, disease activity status and disease damage |
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