The two domains of human galectin-8 bind sialyl- and fucose-containing oligosaccharides in an independent manner. A 3D view by using NMR

The interaction of human galectin-8 and its two separate N-terminal and C-terminal carbohydrate recognition domains (CRD) to their natural ligands has been analysed using a synergistic combination of experimental NMR and ITC methods, and molecular dynamics simulations. Both domains bind the minimal...

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Veröffentlicht in:	RSC chemical biology 2021-06, Vol.2 (3), p.932-941
Hauptverfasser:	Gómez-Redondo, Marcos, Delgado, Sandra, Núñez-Franco, Reyes, Jiménez-Osés, Gonzalo, Ardá, Ana, Jiménez-Barbero, Jesús, Gimeno, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
Online-Zugang:	Volltext
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