Estimation of causal effect in integrating randomized clinical trial and observational data – An example application to cardiovascular outcome trial

Safety evaluation of drug development is a comprehensive process across the product lifecycle. While a randomized clinical trial (RCT) can provide high-quality data to assess the efficacy and safety of a new intervention, the pre-marketing trials are limited in statistical power to detect causal ele...

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Veröffentlicht in:	Contemporary clinical trials 2021-08, Vol.107, p.106492-106492, Article 106492
Hauptverfasser:	Zhang, Yafei, Lin, Li-An, Starkopf, Liis, Chen, Jie, Wang, William W.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiovascular outcome trials Matching Randomized clinical trial Real-world data Targeted learning
Online-Zugang:	Volltext
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