Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a D-galactose-induced ageing mouse model via the regulation of uric acid metabolism
Accumulating evidence has shown that chronic injection of D-galactose (D-gal) can mimic natural ageing and induce liver and kidney injury. Previous studies showed that D-gal increased uric acid (UA) levels in mice. The increase in UA levels caused inflammation, accelerated oxidative stress, and aggr...
Gespeichert in:
| Veröffentlicht in: | Food & function 2021-09, Vol.12 (18), p.8274-8287 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8287 |
|---|---|
| container_issue | 18 |
| container_start_page | 8274 |
| container_title | Food & function |
| container_volume | 12 |
| creator | Li, Lu Li, Yongmei Luo, Jian Jiang, Yanqing Zhao, Zean Chen, Yanyu Huang, Qinghua Zhang, Leqi Wu, Ting Pang, Jianxin |
| description | Accumulating evidence has shown that chronic injection of D-galactose (D-gal) can mimic natural ageing and induce liver and kidney injury. Previous studies showed that D-gal increased uric acid (UA) levels in mice. The increase in UA levels caused inflammation, accelerated oxidative stress, and aggravated liver and kidney injury. Oxidative stress and inflammation play vital roles in the ageing process. Therefore, reducing the levels of UA in ageing mice improved liver and kidney injury. Glucose transporter 9 (GLUT9) is responsible for the reabsorption of UA in the body, and its inhibition helps downregulate UA levels. The present study investigated the UA-lowering activity of the GLUT9 inhibitor resveratrol (RSV) using the patch clamping technique established in our laboratory
. This research is the first study to demonstrate that RSV effectively inhibits UA uptake
GLUT9 (IC
= 68.77 μM)
. An
study was also performed to investigate the possible protective effect of RSV on D-gal-induced liver and kidney injury. RSV significantly reduced serum UA levels
the downregulation of GLUT9 mRNA and protein expression and promoted the excretion of excess UA through urine. Biochemical analysis showed that RSV significantly downregulated abnormal increases in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN) and creatinine (CRE) caused by long-term D-gal treatment, which effectively improved pathological damage, increased superoxide dismutase (SOD) activity and decreased the content of malondialdehyde (MDA) in the liver and kidneys. RSV also downregulated the expression of the inflammatory cytokines, interleukin IL-6, IL-1β and tumor necrosis factor (TNF)-α in the liver and kidneys of ageing mice. Our findings provide new insights into the treatment strategies for ageing-induced liver and kidney injury and reveal a new mechanism of RSV-induced reduction in UA levels in ageing individuals. |
| doi_str_mv | 10.1039/d1fo00538c |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2545991490</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2545991490</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-903016fa82053514a36f79e95b56494d058a14486aedceee7493ecc4d866ac223</originalsourceid><addsrcrecordid>eNpdkctqHDEQRUWIic3Ym3xAEGQTQjqRWo9pLcM4fsCAIdiQXVMjVY81UUuO1D3gD_J_Rn5lES0kQZ26t6hLyHvOvnImzDfHh8SYEp19Q45aJttGK_br7etfGn1ITkrZsXqEMZ3p3pFDIXnHjBBH5OEnlj1mmHIKXyjQmPYYqI-3fuOnlGka6Pn65trU2ojBp0piocHXHgrR0d_eRbyvDbs5-1rxsYqcNlsIYKdUsPHRzRYdhS36uKVjmgvW21WXvQc63SLNuJ0DTD7FR7uqYylY7-iIE2xS8GU8JgcDhIInL--C3Jz9uF5dNOur88vV93VjhdJTY5hgXA_QtXUhiksQelgaNGqj6iKkY6oDLmWnAZ1FxKU0Aq2VrtMabNuKBfn0rHuX058Zy9SPvlgMASLWwftWSWUMl9VoQT7-h-7SnGOdrlJLKYRWQlbq8zNlcyol49DfZT9Cvu856x_z60_52dVTfqsKf3iRnDcjun_oa1riL65Dlic</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2574336534</pqid></control><display><type>article</type><title>Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a D-galactose-induced ageing mouse model via the regulation of uric acid metabolism</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><creator>Li, Lu ; Li, Yongmei ; Luo, Jian ; Jiang, Yanqing ; Zhao, Zean ; Chen, Yanyu ; Huang, Qinghua ; Zhang, Leqi ; Wu, Ting ; Pang, Jianxin</creator><creatorcontrib>Li, Lu ; Li, Yongmei ; Luo, Jian ; Jiang, Yanqing ; Zhao, Zean ; Chen, Yanyu ; Huang, Qinghua ; Zhang, Leqi ; Wu, Ting ; Pang, Jianxin</creatorcontrib><description>Accumulating evidence has shown that chronic injection of D-galactose (D-gal) can mimic natural ageing and induce liver and kidney injury. Previous studies showed that D-gal increased uric acid (UA) levels in mice. The increase in UA levels caused inflammation, accelerated oxidative stress, and aggravated liver and kidney injury. Oxidative stress and inflammation play vital roles in the ageing process. Therefore, reducing the levels of UA in ageing mice improved liver and kidney injury. Glucose transporter 9 (GLUT9) is responsible for the reabsorption of UA in the body, and its inhibition helps downregulate UA levels. The present study investigated the UA-lowering activity of the GLUT9 inhibitor resveratrol (RSV) using the patch clamping technique established in our laboratory
. This research is the first study to demonstrate that RSV effectively inhibits UA uptake
GLUT9 (IC
= 68.77 μM)
. An
study was also performed to investigate the possible protective effect of RSV on D-gal-induced liver and kidney injury. RSV significantly reduced serum UA levels
the downregulation of GLUT9 mRNA and protein expression and promoted the excretion of excess UA through urine. Biochemical analysis showed that RSV significantly downregulated abnormal increases in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN) and creatinine (CRE) caused by long-term D-gal treatment, which effectively improved pathological damage, increased superoxide dismutase (SOD) activity and decreased the content of malondialdehyde (MDA) in the liver and kidneys. RSV also downregulated the expression of the inflammatory cytokines, interleukin IL-6, IL-1β and tumor necrosis factor (TNF)-α in the liver and kidneys of ageing mice. Our findings provide new insights into the treatment strategies for ageing-induced liver and kidney injury and reveal a new mechanism of RSV-induced reduction in UA levels in ageing individuals.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d1fo00538c</identifier><identifier>PMID: 34180933</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Aging ; Aging (artificial) ; Aging (natural) ; Aging - drug effects ; Alanine ; Alanine transaminase ; Animals ; Aspartate aminotransferase ; Biochemical analysis ; Cell Survival - drug effects ; Chemical and Drug Induced Liver Injury - prevention & control ; Creatinine ; Cytokines ; D-Galactose ; Epithelial Cells - drug effects ; Female ; Galactose ; Galactose - toxicity ; Gene expression ; Gene Expression Regulation - drug effects ; Glucose Transport Proteins, Facilitative - antagonists & inhibitors ; Glucose Transport Proteins, Facilitative - genetics ; Glucose Transport Proteins, Facilitative - metabolism ; Glucose transporter ; In vivo methods and tests ; Inflammation ; Injury prevention ; Interleukin 6 ; Kidney - drug effects ; Kidney Tubules - cytology ; Kidneys ; Liver ; Liver - drug effects ; Male ; Malondialdehyde ; Metabolism ; Mice ; Molecular Structure ; mRNA ; Organic Anion Transporters - antagonists & inhibitors ; Organic Anion Transporters - genetics ; Organic Anion Transporters - metabolism ; Oxidative stress ; Reabsorption ; Resveratrol ; Resveratrol - chemistry ; Resveratrol - pharmacology ; Serum levels ; Superoxide dismutase ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Urea ; Uric acid ; Uric Acid - metabolism</subject><ispartof>Food & function, 2021-09, Vol.12 (18), p.8274-8287</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-903016fa82053514a36f79e95b56494d058a14486aedceee7493ecc4d866ac223</citedby><cites>FETCH-LOGICAL-c356t-903016fa82053514a36f79e95b56494d058a14486aedceee7493ecc4d866ac223</cites><orcidid>0000-0003-3082-4265</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34180933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Lu</creatorcontrib><creatorcontrib>Li, Yongmei</creatorcontrib><creatorcontrib>Luo, Jian</creatorcontrib><creatorcontrib>Jiang, Yanqing</creatorcontrib><creatorcontrib>Zhao, Zean</creatorcontrib><creatorcontrib>Chen, Yanyu</creatorcontrib><creatorcontrib>Huang, Qinghua</creatorcontrib><creatorcontrib>Zhang, Leqi</creatorcontrib><creatorcontrib>Wu, Ting</creatorcontrib><creatorcontrib>Pang, Jianxin</creatorcontrib><title>Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a D-galactose-induced ageing mouse model via the regulation of uric acid metabolism</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Accumulating evidence has shown that chronic injection of D-galactose (D-gal) can mimic natural ageing and induce liver and kidney injury. Previous studies showed that D-gal increased uric acid (UA) levels in mice. The increase in UA levels caused inflammation, accelerated oxidative stress, and aggravated liver and kidney injury. Oxidative stress and inflammation play vital roles in the ageing process. Therefore, reducing the levels of UA in ageing mice improved liver and kidney injury. Glucose transporter 9 (GLUT9) is responsible for the reabsorption of UA in the body, and its inhibition helps downregulate UA levels. The present study investigated the UA-lowering activity of the GLUT9 inhibitor resveratrol (RSV) using the patch clamping technique established in our laboratory
. This research is the first study to demonstrate that RSV effectively inhibits UA uptake
GLUT9 (IC
= 68.77 μM)
. An
study was also performed to investigate the possible protective effect of RSV on D-gal-induced liver and kidney injury. RSV significantly reduced serum UA levels
the downregulation of GLUT9 mRNA and protein expression and promoted the excretion of excess UA through urine. Biochemical analysis showed that RSV significantly downregulated abnormal increases in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN) and creatinine (CRE) caused by long-term D-gal treatment, which effectively improved pathological damage, increased superoxide dismutase (SOD) activity and decreased the content of malondialdehyde (MDA) in the liver and kidneys. RSV also downregulated the expression of the inflammatory cytokines, interleukin IL-6, IL-1β and tumor necrosis factor (TNF)-α in the liver and kidneys of ageing mice. Our findings provide new insights into the treatment strategies for ageing-induced liver and kidney injury and reveal a new mechanism of RSV-induced reduction in UA levels in ageing individuals.</description><subject>Aging</subject><subject>Aging (artificial)</subject><subject>Aging (natural)</subject><subject>Aging - drug effects</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Animals</subject><subject>Aspartate aminotransferase</subject><subject>Biochemical analysis</subject><subject>Cell Survival - drug effects</subject><subject>Chemical and Drug Induced Liver Injury - prevention & control</subject><subject>Creatinine</subject><subject>Cytokines</subject><subject>D-Galactose</subject><subject>Epithelial Cells - drug effects</subject><subject>Female</subject><subject>Galactose</subject><subject>Galactose - toxicity</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glucose Transport Proteins, Facilitative - antagonists & inhibitors</subject><subject>Glucose Transport Proteins, Facilitative - genetics</subject><subject>Glucose Transport Proteins, Facilitative - metabolism</subject><subject>Glucose transporter</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Injury prevention</subject><subject>Interleukin 6</subject><subject>Kidney - drug effects</subject><subject>Kidney Tubules - cytology</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>mRNA</subject><subject>Organic Anion Transporters - antagonists & inhibitors</subject><subject>Organic Anion Transporters - genetics</subject><subject>Organic Anion Transporters - metabolism</subject><subject>Oxidative stress</subject><subject>Reabsorption</subject><subject>Resveratrol</subject><subject>Resveratrol - chemistry</subject><subject>Resveratrol - pharmacology</subject><subject>Serum levels</subject><subject>Superoxide dismutase</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Urea</subject><subject>Uric acid</subject><subject>Uric Acid - metabolism</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctqHDEQRUWIic3Ym3xAEGQTQjqRWo9pLcM4fsCAIdiQXVMjVY81UUuO1D3gD_J_Rn5lES0kQZ26t6hLyHvOvnImzDfHh8SYEp19Q45aJttGK_br7etfGn1ITkrZsXqEMZ3p3pFDIXnHjBBH5OEnlj1mmHIKXyjQmPYYqI-3fuOnlGka6Pn65trU2ojBp0piocHXHgrR0d_eRbyvDbs5-1rxsYqcNlsIYKdUsPHRzRYdhS36uKVjmgvW21WXvQc63SLNuJ0DTD7FR7uqYylY7-iIE2xS8GU8JgcDhIInL--C3Jz9uF5dNOur88vV93VjhdJTY5hgXA_QtXUhiksQelgaNGqj6iKkY6oDLmWnAZ1FxKU0Aq2VrtMabNuKBfn0rHuX058Zy9SPvlgMASLWwftWSWUMl9VoQT7-h-7SnGOdrlJLKYRWQlbq8zNlcyol49DfZT9Cvu856x_z60_52dVTfqsKf3iRnDcjun_oa1riL65Dlic</recordid><startdate>20210920</startdate><enddate>20210920</enddate><creator>Li, Lu</creator><creator>Li, Yongmei</creator><creator>Luo, Jian</creator><creator>Jiang, Yanqing</creator><creator>Zhao, Zean</creator><creator>Chen, Yanyu</creator><creator>Huang, Qinghua</creator><creator>Zhang, Leqi</creator><creator>Wu, Ting</creator><creator>Pang, Jianxin</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3082-4265</orcidid></search><sort><creationdate>20210920</creationdate><title>Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a D-galactose-induced ageing mouse model via the regulation of uric acid metabolism</title><author>Li, Lu ; Li, Yongmei ; Luo, Jian ; Jiang, Yanqing ; Zhao, Zean ; Chen, Yanyu ; Huang, Qinghua ; Zhang, Leqi ; Wu, Ting ; Pang, Jianxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-903016fa82053514a36f79e95b56494d058a14486aedceee7493ecc4d866ac223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aging</topic><topic>Aging (artificial)</topic><topic>Aging (natural)</topic><topic>Aging - drug effects</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Animals</topic><topic>Aspartate aminotransferase</topic><topic>Biochemical analysis</topic><topic>Cell Survival - drug effects</topic><topic>Chemical and Drug Induced Liver Injury - prevention & control</topic><topic>Creatinine</topic><topic>Cytokines</topic><topic>D-Galactose</topic><topic>Epithelial Cells - drug effects</topic><topic>Female</topic><topic>Galactose</topic><topic>Galactose - toxicity</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glucose Transport Proteins, Facilitative - antagonists & inhibitors</topic><topic>Glucose Transport Proteins, Facilitative - genetics</topic><topic>Glucose Transport Proteins, Facilitative - metabolism</topic><topic>Glucose transporter</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>Injury prevention</topic><topic>Interleukin 6</topic><topic>Kidney - drug effects</topic><topic>Kidney Tubules - cytology</topic><topic>Kidneys</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>mRNA</topic><topic>Organic Anion Transporters - antagonists & inhibitors</topic><topic>Organic Anion Transporters - genetics</topic><topic>Organic Anion Transporters - metabolism</topic><topic>Oxidative stress</topic><topic>Reabsorption</topic><topic>Resveratrol</topic><topic>Resveratrol - chemistry</topic><topic>Resveratrol - pharmacology</topic><topic>Serum levels</topic><topic>Superoxide dismutase</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Urea</topic><topic>Uric acid</topic><topic>Uric Acid - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Lu</creatorcontrib><creatorcontrib>Li, Yongmei</creatorcontrib><creatorcontrib>Luo, Jian</creatorcontrib><creatorcontrib>Jiang, Yanqing</creatorcontrib><creatorcontrib>Zhao, Zean</creatorcontrib><creatorcontrib>Chen, Yanyu</creatorcontrib><creatorcontrib>Huang, Qinghua</creatorcontrib><creatorcontrib>Zhang, Leqi</creatorcontrib><creatorcontrib>Wu, Ting</creatorcontrib><creatorcontrib>Pang, Jianxin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Lu</au><au>Li, Yongmei</au><au>Luo, Jian</au><au>Jiang, Yanqing</au><au>Zhao, Zean</au><au>Chen, Yanyu</au><au>Huang, Qinghua</au><au>Zhang, Leqi</au><au>Wu, Ting</au><au>Pang, Jianxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a D-galactose-induced ageing mouse model via the regulation of uric acid metabolism</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2021-09-20</date><risdate>2021</risdate><volume>12</volume><issue>18</issue><spage>8274</spage><epage>8287</epage><pages>8274-8287</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Accumulating evidence has shown that chronic injection of D-galactose (D-gal) can mimic natural ageing and induce liver and kidney injury. Previous studies showed that D-gal increased uric acid (UA) levels in mice. The increase in UA levels caused inflammation, accelerated oxidative stress, and aggravated liver and kidney injury. Oxidative stress and inflammation play vital roles in the ageing process. Therefore, reducing the levels of UA in ageing mice improved liver and kidney injury. Glucose transporter 9 (GLUT9) is responsible for the reabsorption of UA in the body, and its inhibition helps downregulate UA levels. The present study investigated the UA-lowering activity of the GLUT9 inhibitor resveratrol (RSV) using the patch clamping technique established in our laboratory
. This research is the first study to demonstrate that RSV effectively inhibits UA uptake
GLUT9 (IC
= 68.77 μM)
. An
study was also performed to investigate the possible protective effect of RSV on D-gal-induced liver and kidney injury. RSV significantly reduced serum UA levels
the downregulation of GLUT9 mRNA and protein expression and promoted the excretion of excess UA through urine. Biochemical analysis showed that RSV significantly downregulated abnormal increases in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN) and creatinine (CRE) caused by long-term D-gal treatment, which effectively improved pathological damage, increased superoxide dismutase (SOD) activity and decreased the content of malondialdehyde (MDA) in the liver and kidneys. RSV also downregulated the expression of the inflammatory cytokines, interleukin IL-6, IL-1β and tumor necrosis factor (TNF)-α in the liver and kidneys of ageing mice. Our findings provide new insights into the treatment strategies for ageing-induced liver and kidney injury and reveal a new mechanism of RSV-induced reduction in UA levels in ageing individuals.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>34180933</pmid><doi>10.1039/d1fo00538c</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-3082-4265</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2042-6496 |
| ispartof | Food & function, 2021-09, Vol.12 (18), p.8274-8287 |
| issn | 2042-6496 2042-650X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2545991490 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Aging Aging (artificial) Aging (natural) Aging - drug effects Alanine Alanine transaminase Animals Aspartate aminotransferase Biochemical analysis Cell Survival - drug effects Chemical and Drug Induced Liver Injury - prevention & control Creatinine Cytokines D-Galactose Epithelial Cells - drug effects Female Galactose Galactose - toxicity Gene expression Gene Expression Regulation - drug effects Glucose Transport Proteins, Facilitative - antagonists & inhibitors Glucose Transport Proteins, Facilitative - genetics Glucose Transport Proteins, Facilitative - metabolism Glucose transporter In vivo methods and tests Inflammation Injury prevention Interleukin 6 Kidney - drug effects Kidney Tubules - cytology Kidneys Liver Liver - drug effects Male Malondialdehyde Metabolism Mice Molecular Structure mRNA Organic Anion Transporters - antagonists & inhibitors Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Oxidative stress Reabsorption Resveratrol Resveratrol - chemistry Resveratrol - pharmacology Serum levels Superoxide dismutase Tumor necrosis factor-TNF Tumor necrosis factor-α Urea Uric acid Uric Acid - metabolism |
| title | Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a D-galactose-induced ageing mouse model via the regulation of uric acid metabolism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T13%3A57%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Resveratrol,%20a%20novel%20inhibitor%20of%20GLUT9,%20ameliorates%20liver%20and%20kidney%20injuries%20in%20a%20D-galactose-induced%20ageing%20mouse%20model%20via%20the%20regulation%20of%20uric%20acid%20metabolism&rft.jtitle=Food%20&%20function&rft.au=Li,%20Lu&rft.date=2021-09-20&rft.volume=12&rft.issue=18&rft.spage=8274&rft.epage=8287&rft.pages=8274-8287&rft.issn=2042-6496&rft.eissn=2042-650X&rft_id=info:doi/10.1039/d1fo00538c&rft_dat=%3Cproquest_cross%3E2545991490%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2574336534&rft_id=info:pmid/34180933&rfr_iscdi=true |