Inhibition of gastric H+,K+-ATPase by new dihydropyrazole derivative KYY-008

The gastric proton pump (H+,K+-ATPase) responsible for the H+ secretion of gastric acid is an essential therapeutic target for acid-related diseases. H+,K+-ATPase belongs to a P2-type ATPase family. Here, we examined the effects of a newly synthesized dihydropyrazole derivative KYY-008 on the H+,K+-...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-08, Vol.567, p.177-182
Hauptverfasser:	Fujii, Takuto, Sugimoto, Kenji, Noda, Takafumi, Shimizu, Takahiro, Matsuya, Yuji, Sakai, Hideki
Format:	Artikel
Sprache:	eng
Schlagworte:	Dihydropyrazole Gastric proton pump H+,K+-ATPase Stomach
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