The dynamic effects of preoperative intravenous iron in anaemic patients undergoing surgery for colorectal cancer
Aim The aim of this study was to describe the dynamic changes in blood work following individual adjusted dosage of intravenously administered iron(III) isomaltoside in a 4‐week period prior to surgery in patients with colorectal cancer. Methods This was a single‐centre, observational cohort study w...
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| Veröffentlicht in: | Colorectal disease 2021-10, Vol.23 (10), p.2550-2558 |
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| creator | Bojesen, Rasmus Dahlin Eriksen, Jens Ravn Vogelsang, Rasmus Peuliche Grube, Camilla Forman, Julie Lyng Gogenür, Ismail |
| description | Aim
The aim of this study was to describe the dynamic changes in blood work following individual adjusted dosage of intravenously administered iron(III) isomaltoside in a 4‐week period prior to surgery in patients with colorectal cancer.
Methods
This was a single‐centre, observational cohort study with prospectively collected data, including patients with colorectal cancer receiving preoperative treatment with iron(III) isomaltoside. Blood samples were taken at baseline, 1 week, 2 weeks and 4 weeks after initial treatment. Sixty‐two patients were included in the study.
Results
Sixty‐two patients were included for final analysis. The mean increase in haemoglobin was 0.77 g/dl (95% CI 0.52–1.03 g/dl, P |
| doi_str_mv | 10.1111/codi.15789 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2545604553</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2585291157</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3579-f803a2503bc9c4938ea5b82967938b557ff55041ae1e1ef33bbf45ce064b4d823</originalsourceid><addsrcrecordid>eNp9kctOAyEUhonRWG8bH8CQuDEmU2GAGWZp6jVp4kbXE4Y5VJopjNCp6dtLW3XhQlhwQr7zBc6P0DklY5rWjfatHVNRymoPHVFesIwyKve3dZ7JipIROo5xTggtSioP0YhxWhSizI_Qx-s74Hbt1MJqDMaAXkbsDe4D-B6CWtoVYOuWQa3A-SFiG7xLF1g5BZuePiHgUtPgWggzb90MxyHMIKyx8QFr3_mQrKrDWjkN4RQdGNVFOPs-T9Dbw_3r5Cmbvjw-T26nmWairDIjCVO5IKzRleYVk6BEI_OqKFPdCFEaIwThVAFN2zDWNIYLDaTgDW9lzk7Q1c7bB_8xQFzWCxs1dJ1ykD5S54KLgnAhWEIv_6BzPwSXXpcoKfKKpukm6npH6eBjDGDqPtiFCuuaknoTRL0Jot4GkeCLb-XQLKD9RX8mnwC6Az5tB-t_VPXk5e55J_0CraiUVQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2585291157</pqid></control><display><type>article</type><title>The dynamic effects of preoperative intravenous iron in anaemic patients undergoing surgery for colorectal cancer</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Bojesen, Rasmus Dahlin ; Eriksen, Jens Ravn ; Vogelsang, Rasmus Peuliche ; Grube, Camilla ; Forman, Julie Lyng ; Gogenür, Ismail</creator><creatorcontrib>Bojesen, Rasmus Dahlin ; Eriksen, Jens Ravn ; Vogelsang, Rasmus Peuliche ; Grube, Camilla ; Forman, Julie Lyng ; Gogenür, Ismail</creatorcontrib><description><![CDATA[Aim
The aim of this study was to describe the dynamic changes in blood work following individual adjusted dosage of intravenously administered iron(III) isomaltoside in a 4‐week period prior to surgery in patients with colorectal cancer.
Methods
This was a single‐centre, observational cohort study with prospectively collected data, including patients with colorectal cancer receiving preoperative treatment with iron(III) isomaltoside. Blood samples were taken at baseline, 1 week, 2 weeks and 4 weeks after initial treatment. Sixty‐two patients were included in the study.
Results
Sixty‐two patients were included for final analysis. The mean increase in haemoglobin was 0.77 g/dl (95% CI 0.52–1.03 g/dl, P < 0.0001) at week 1, 1.5 g/dl (95% CI 1.21–1.80 g/dl, P < 0.0001) at week 2 and 2.13 g/dl (95% CI 1.71–2.55 g/dl, P < 0.0001) at week 4. Patients with severe anaemia (<9.02 g/dl) showed the largest increase in haemoglobin during the treatment course (2.92 g/dl, 95% CI 2.27–3.58 g/dl, P < 0.0001). Patients with mild anaemia (>10.31 g/dl) did not show a significant increase (0.66 g/dl, 95% CI −0.29–1.61 g/dl, P = 0.17). The mean of transferrin saturation after 4 weeks was 8% (95% CI 6%–10%, P < 0.0001).
Conclusions
After intravenously administered iron, patients with severe anaemia had the most substantial increase in haemoglobin, and the increase was largest after 4 weeks. Patients with mild anaemia did not have an increase in haemoglobin during the treatment course. The vast majority of patients still had iron deficiency at surgery 4 weeks after the initial treatment.]]></description><identifier>ISSN: 1462-8910</identifier><identifier>EISSN: 1463-1318</identifier><identifier>DOI: 10.1111/codi.15789</identifier><identifier>PMID: 34166572</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>anaemia ; Anemia ; Anemia - etiology ; Anemia, Iron-Deficiency - drug therapy ; Anemia, Iron-Deficiency - etiology ; Cancer ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - complications ; Colorectal Neoplasms - surgery ; Hemoglobin ; Hemoglobins ; Humans ; Intravenous administration ; Iron ; Iron deficiency ; Nutrient deficiency ; Patients ; Surgery ; Transferrins</subject><ispartof>Colorectal disease, 2021-10, Vol.23 (10), p.2550-2558</ispartof><rights>2021 Association of Coloproctology of Great Britain and Ireland.</rights><rights>Copyright © 2021 The Association of Coloproctology of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3579-f803a2503bc9c4938ea5b82967938b557ff55041ae1e1ef33bbf45ce064b4d823</citedby><cites>FETCH-LOGICAL-c3579-f803a2503bc9c4938ea5b82967938b557ff55041ae1e1ef33bbf45ce064b4d823</cites><orcidid>0000-0003-0081-5093</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcodi.15789$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcodi.15789$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34166572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bojesen, Rasmus Dahlin</creatorcontrib><creatorcontrib>Eriksen, Jens Ravn</creatorcontrib><creatorcontrib>Vogelsang, Rasmus Peuliche</creatorcontrib><creatorcontrib>Grube, Camilla</creatorcontrib><creatorcontrib>Forman, Julie Lyng</creatorcontrib><creatorcontrib>Gogenür, Ismail</creatorcontrib><title>The dynamic effects of preoperative intravenous iron in anaemic patients undergoing surgery for colorectal cancer</title><title>Colorectal disease</title><addtitle>Colorectal Dis</addtitle><description><![CDATA[Aim
The aim of this study was to describe the dynamic changes in blood work following individual adjusted dosage of intravenously administered iron(III) isomaltoside in a 4‐week period prior to surgery in patients with colorectal cancer.
Methods
This was a single‐centre, observational cohort study with prospectively collected data, including patients with colorectal cancer receiving preoperative treatment with iron(III) isomaltoside. Blood samples were taken at baseline, 1 week, 2 weeks and 4 weeks after initial treatment. Sixty‐two patients were included in the study.
Results
Sixty‐two patients were included for final analysis. The mean increase in haemoglobin was 0.77 g/dl (95% CI 0.52–1.03 g/dl, P < 0.0001) at week 1, 1.5 g/dl (95% CI 1.21–1.80 g/dl, P < 0.0001) at week 2 and 2.13 g/dl (95% CI 1.71–2.55 g/dl, P < 0.0001) at week 4. Patients with severe anaemia (<9.02 g/dl) showed the largest increase in haemoglobin during the treatment course (2.92 g/dl, 95% CI 2.27–3.58 g/dl, P < 0.0001). Patients with mild anaemia (>10.31 g/dl) did not show a significant increase (0.66 g/dl, 95% CI −0.29–1.61 g/dl, P = 0.17). The mean of transferrin saturation after 4 weeks was 8% (95% CI 6%–10%, P < 0.0001).
Conclusions
After intravenously administered iron, patients with severe anaemia had the most substantial increase in haemoglobin, and the increase was largest after 4 weeks. Patients with mild anaemia did not have an increase in haemoglobin during the treatment course. The vast majority of patients still had iron deficiency at surgery 4 weeks after the initial treatment.]]></description><subject>anaemia</subject><subject>Anemia</subject><subject>Anemia - etiology</subject><subject>Anemia, Iron-Deficiency - drug therapy</subject><subject>Anemia, Iron-Deficiency - etiology</subject><subject>Cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - complications</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Hemoglobin</subject><subject>Hemoglobins</subject><subject>Humans</subject><subject>Intravenous administration</subject><subject>Iron</subject><subject>Iron deficiency</subject><subject>Nutrient deficiency</subject><subject>Patients</subject><subject>Surgery</subject><subject>Transferrins</subject><issn>1462-8910</issn><issn>1463-1318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOAyEUhonRWG8bH8CQuDEmU2GAGWZp6jVp4kbXE4Y5VJopjNCp6dtLW3XhQlhwQr7zBc6P0DklY5rWjfatHVNRymoPHVFesIwyKve3dZ7JipIROo5xTggtSioP0YhxWhSizI_Qx-s74Hbt1MJqDMaAXkbsDe4D-B6CWtoVYOuWQa3A-SFiG7xLF1g5BZuePiHgUtPgWggzb90MxyHMIKyx8QFr3_mQrKrDWjkN4RQdGNVFOPs-T9Dbw_3r5Cmbvjw-T26nmWairDIjCVO5IKzRleYVk6BEI_OqKFPdCFEaIwThVAFN2zDWNIYLDaTgDW9lzk7Q1c7bB_8xQFzWCxs1dJ1ykD5S54KLgnAhWEIv_6BzPwSXXpcoKfKKpukm6npH6eBjDGDqPtiFCuuaknoTRL0Jot4GkeCLb-XQLKD9RX8mnwC6Az5tB-t_VPXk5e55J_0CraiUVQ</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Bojesen, Rasmus Dahlin</creator><creator>Eriksen, Jens Ravn</creator><creator>Vogelsang, Rasmus Peuliche</creator><creator>Grube, Camilla</creator><creator>Forman, Julie Lyng</creator><creator>Gogenür, Ismail</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0081-5093</orcidid></search><sort><creationdate>202110</creationdate><title>The dynamic effects of preoperative intravenous iron in anaemic patients undergoing surgery for colorectal cancer</title><author>Bojesen, Rasmus Dahlin ; Eriksen, Jens Ravn ; Vogelsang, Rasmus Peuliche ; Grube, Camilla ; Forman, Julie Lyng ; Gogenür, Ismail</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3579-f803a2503bc9c4938ea5b82967938b557ff55041ae1e1ef33bbf45ce064b4d823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>anaemia</topic><topic>Anemia</topic><topic>Anemia - etiology</topic><topic>Anemia, Iron-Deficiency - drug therapy</topic><topic>Anemia, Iron-Deficiency - etiology</topic><topic>Cancer</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - complications</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Hemoglobin</topic><topic>Hemoglobins</topic><topic>Humans</topic><topic>Intravenous administration</topic><topic>Iron</topic><topic>Iron deficiency</topic><topic>Nutrient deficiency</topic><topic>Patients</topic><topic>Surgery</topic><topic>Transferrins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bojesen, Rasmus Dahlin</creatorcontrib><creatorcontrib>Eriksen, Jens Ravn</creatorcontrib><creatorcontrib>Vogelsang, Rasmus Peuliche</creatorcontrib><creatorcontrib>Grube, Camilla</creatorcontrib><creatorcontrib>Forman, Julie Lyng</creatorcontrib><creatorcontrib>Gogenür, Ismail</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bojesen, Rasmus Dahlin</au><au>Eriksen, Jens Ravn</au><au>Vogelsang, Rasmus Peuliche</au><au>Grube, Camilla</au><au>Forman, Julie Lyng</au><au>Gogenür, Ismail</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The dynamic effects of preoperative intravenous iron in anaemic patients undergoing surgery for colorectal cancer</atitle><jtitle>Colorectal disease</jtitle><addtitle>Colorectal Dis</addtitle><date>2021-10</date><risdate>2021</risdate><volume>23</volume><issue>10</issue><spage>2550</spage><epage>2558</epage><pages>2550-2558</pages><issn>1462-8910</issn><eissn>1463-1318</eissn><abstract><![CDATA[Aim
The aim of this study was to describe the dynamic changes in blood work following individual adjusted dosage of intravenously administered iron(III) isomaltoside in a 4‐week period prior to surgery in patients with colorectal cancer.
Methods
This was a single‐centre, observational cohort study with prospectively collected data, including patients with colorectal cancer receiving preoperative treatment with iron(III) isomaltoside. Blood samples were taken at baseline, 1 week, 2 weeks and 4 weeks after initial treatment. Sixty‐two patients were included in the study.
Results
Sixty‐two patients were included for final analysis. The mean increase in haemoglobin was 0.77 g/dl (95% CI 0.52–1.03 g/dl, P < 0.0001) at week 1, 1.5 g/dl (95% CI 1.21–1.80 g/dl, P < 0.0001) at week 2 and 2.13 g/dl (95% CI 1.71–2.55 g/dl, P < 0.0001) at week 4. Patients with severe anaemia (<9.02 g/dl) showed the largest increase in haemoglobin during the treatment course (2.92 g/dl, 95% CI 2.27–3.58 g/dl, P < 0.0001). Patients with mild anaemia (>10.31 g/dl) did not show a significant increase (0.66 g/dl, 95% CI −0.29–1.61 g/dl, P = 0.17). The mean of transferrin saturation after 4 weeks was 8% (95% CI 6%–10%, P < 0.0001).
Conclusions
After intravenously administered iron, patients with severe anaemia had the most substantial increase in haemoglobin, and the increase was largest after 4 weeks. Patients with mild anaemia did not have an increase in haemoglobin during the treatment course. The vast majority of patients still had iron deficiency at surgery 4 weeks after the initial treatment.]]></abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34166572</pmid><doi>10.1111/codi.15789</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0081-5093</orcidid></addata></record> |
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| subjects | anaemia Anemia Anemia - etiology Anemia, Iron-Deficiency - drug therapy Anemia, Iron-Deficiency - etiology Cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - complications Colorectal Neoplasms - surgery Hemoglobin Hemoglobins Humans Intravenous administration Iron Iron deficiency Nutrient deficiency Patients Surgery Transferrins |
| title | The dynamic effects of preoperative intravenous iron in anaemic patients undergoing surgery for colorectal cancer |
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