History of depression is associated with worsened postoperative outcomes following colectomy
Aim Depression is a prevalent disorder that is associated with adverse health outcomes, but an understanding of its effect in colorectal surgery remains limited. The purpose of this study was to examine the impact of history of depression among patients undergoing colectomy. Method United States pat...
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| Veröffentlicht in: | Colorectal disease 2021-10, Vol.23 (10), p.2559-2566 |
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| creator | Zhang, George Q. Canner, Joseph K. Prince, Elizabeth J. Stem, Miloslawa Taylor, James P. Efron, Jonathan E. Atallah, Chady Safar, Bashar |
| description | Aim
Depression is a prevalent disorder that is associated with adverse health outcomes, but an understanding of its effect in colorectal surgery remains limited. The purpose of this study was to examine the impact of history of depression among patients undergoing colectomy.
Method
United States patients from Marketscan (2010–2017) who underwent colectomy were included and stratified by whether they had a history of depression within the past year, defined as (1) a diagnosis of depression during the index admission, (2) a diagnosis of depression during any inpatient or (3) outpatient admission within the year, and/or (4) a pharmacy claim for an antidepressant within the year. The primary outcomes were length of stay (LOS) and inpatient hospital charge. Secondary outcomes included in‐hospital mortality and postoperative complications. Logistic, negative binomial, and quantile regressions were performed.
Results
Among 88 981 patients, 21 878 (24.6%) had a history of depression. Compared to those without, patients with a history of depression had significantly longer LOS (IRR = 1.06, 95% CI [1.05, 1.07]), increased inpatient charge (β = 467, 95% CI [167, 767]), and increased odds of in‐hospital mortality (OR = 1.37, 95% CI [1.08, 1.73]) after adjustment. History of depression was also independently associated with increased odds of respiratory complication, pneumonia, and delirium (all P |
| doi_str_mv | 10.1111/codi.15790 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2545603733</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2585291131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3290-aeb249c84b7014182e3235f944b21a6b1065d40469d376fb32a4808c5914a5d63</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhosouK5e_AUBLyJ0zSTp11HWj11Y2IvehJKmqWZpOzVpLf33Znc9eXAuMwPPOwxPEFwDXYCve4WlWUCUZPQkmIGIeQgc0tPDzMI0A3oeXDi3oxTiBNJZ8L4yrkc7EaxIqTurnTPYEuOIdA6Vkb0uyWj6TzKidbr1W4c-0Wkre_OtCQ69wkY7UmFd42jaD6Kw1qrHZroMzipZO3312-fB2_PT63IVbrYv6-XDJlScZTSUumAiU6koEgoCUqY541GVCVEwkHEBNI5KQUWclTyJq4IzKVKaqigDIaMy5vPg9ni3s_g1aNfnjXFK17VsNQ4uZ5GIYsoTzj168wfd4WBb_52n0ohl4IV56u5IKYvOWV3lnTWNtFMONN-Lzvei84NoD8MRHk2tp3_IfLl9XB8zPxqBgFo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2585291131</pqid></control><display><type>article</type><title>History of depression is associated with worsened postoperative outcomes following colectomy</title><source>Wiley Journals</source><creator>Zhang, George Q. ; Canner, Joseph K. ; Prince, Elizabeth J. ; Stem, Miloslawa ; Taylor, James P. ; Efron, Jonathan E. ; Atallah, Chady ; Safar, Bashar</creator><creatorcontrib>Zhang, George Q. ; Canner, Joseph K. ; Prince, Elizabeth J. ; Stem, Miloslawa ; Taylor, James P. ; Efron, Jonathan E. ; Atallah, Chady ; Safar, Bashar</creatorcontrib><description>Aim
Depression is a prevalent disorder that is associated with adverse health outcomes, but an understanding of its effect in colorectal surgery remains limited. The purpose of this study was to examine the impact of history of depression among patients undergoing colectomy.
Method
United States patients from Marketscan (2010–2017) who underwent colectomy were included and stratified by whether they had a history of depression within the past year, defined as (1) a diagnosis of depression during the index admission, (2) a diagnosis of depression during any inpatient or (3) outpatient admission within the year, and/or (4) a pharmacy claim for an antidepressant within the year. The primary outcomes were length of stay (LOS) and inpatient hospital charge. Secondary outcomes included in‐hospital mortality and postoperative complications. Logistic, negative binomial, and quantile regressions were performed.
Results
Among 88 981 patients, 21 878 (24.6%) had a history of depression. Compared to those without, patients with a history of depression had significantly longer LOS (IRR = 1.06, 95% CI [1.05, 1.07]), increased inpatient charge (β = 467, 95% CI [167, 767]), and increased odds of in‐hospital mortality (OR = 1.37, 95% CI [1.08, 1.73]) after adjustment. History of depression was also independently associated with increased odds of respiratory complication, pneumonia, and delirium (all P < 0.05).
Conclusion
History of depression was prevalent among individuals undergoing colectomy, and associated with greater mortality and inpatient charge, longer LOS, and higher odds of postoperative complication. These findings highlight the impact of depression in colorectal surgery patients and suggest that proper identification and treatment may reduce postoperative morbidity.</description><identifier>ISSN: 1462-8910</identifier><identifier>EISSN: 1463-1318</identifier><identifier>DOI: 10.1111/codi.15790</identifier><language>eng</language><publisher>Chichester: Wiley Subscription Services, Inc</publisher><subject>colectomy ; Colorectal surgery ; Complications ; depression ; Diagnosis ; length of stay ; Mental depression ; mental health ; Morbidity ; Mortality ; Patients ; Postoperative ; Surgery</subject><ispartof>Colorectal disease, 2021-10, Vol.23 (10), p.2559-2566</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3290-aeb249c84b7014182e3235f944b21a6b1065d40469d376fb32a4808c5914a5d63</cites><orcidid>0000-0002-0623-6271 ; 0000-0001-7712-9628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcodi.15790$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcodi.15790$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Zhang, George Q.</creatorcontrib><creatorcontrib>Canner, Joseph K.</creatorcontrib><creatorcontrib>Prince, Elizabeth J.</creatorcontrib><creatorcontrib>Stem, Miloslawa</creatorcontrib><creatorcontrib>Taylor, James P.</creatorcontrib><creatorcontrib>Efron, Jonathan E.</creatorcontrib><creatorcontrib>Atallah, Chady</creatorcontrib><creatorcontrib>Safar, Bashar</creatorcontrib><title>History of depression is associated with worsened postoperative outcomes following colectomy</title><title>Colorectal disease</title><description>Aim
Depression is a prevalent disorder that is associated with adverse health outcomes, but an understanding of its effect in colorectal surgery remains limited. The purpose of this study was to examine the impact of history of depression among patients undergoing colectomy.
Method
United States patients from Marketscan (2010–2017) who underwent colectomy were included and stratified by whether they had a history of depression within the past year, defined as (1) a diagnosis of depression during the index admission, (2) a diagnosis of depression during any inpatient or (3) outpatient admission within the year, and/or (4) a pharmacy claim for an antidepressant within the year. The primary outcomes were length of stay (LOS) and inpatient hospital charge. Secondary outcomes included in‐hospital mortality and postoperative complications. Logistic, negative binomial, and quantile regressions were performed.
Results
Among 88 981 patients, 21 878 (24.6%) had a history of depression. Compared to those without, patients with a history of depression had significantly longer LOS (IRR = 1.06, 95% CI [1.05, 1.07]), increased inpatient charge (β = 467, 95% CI [167, 767]), and increased odds of in‐hospital mortality (OR = 1.37, 95% CI [1.08, 1.73]) after adjustment. History of depression was also independently associated with increased odds of respiratory complication, pneumonia, and delirium (all P < 0.05).
Conclusion
History of depression was prevalent among individuals undergoing colectomy, and associated with greater mortality and inpatient charge, longer LOS, and higher odds of postoperative complication. These findings highlight the impact of depression in colorectal surgery patients and suggest that proper identification and treatment may reduce postoperative morbidity.</description><subject>colectomy</subject><subject>Colorectal surgery</subject><subject>Complications</subject><subject>depression</subject><subject>Diagnosis</subject><subject>length of stay</subject><subject>Mental depression</subject><subject>mental health</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Patients</subject><subject>Postoperative</subject><subject>Surgery</subject><issn>1462-8910</issn><issn>1463-1318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp9kE1LxDAQhosouK5e_AUBLyJ0zSTp11HWj11Y2IvehJKmqWZpOzVpLf33Znc9eXAuMwPPOwxPEFwDXYCve4WlWUCUZPQkmIGIeQgc0tPDzMI0A3oeXDi3oxTiBNJZ8L4yrkc7EaxIqTurnTPYEuOIdA6Vkb0uyWj6TzKidbr1W4c-0Wkre_OtCQ69wkY7UmFd42jaD6Kw1qrHZroMzipZO3312-fB2_PT63IVbrYv6-XDJlScZTSUumAiU6koEgoCUqY541GVCVEwkHEBNI5KQUWclTyJq4IzKVKaqigDIaMy5vPg9ni3s_g1aNfnjXFK17VsNQ4uZ5GIYsoTzj168wfd4WBb_52n0ohl4IV56u5IKYvOWV3lnTWNtFMONN-Lzvei84NoD8MRHk2tp3_IfLl9XB8zPxqBgFo</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Zhang, George Q.</creator><creator>Canner, Joseph K.</creator><creator>Prince, Elizabeth J.</creator><creator>Stem, Miloslawa</creator><creator>Taylor, James P.</creator><creator>Efron, Jonathan E.</creator><creator>Atallah, Chady</creator><creator>Safar, Bashar</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0623-6271</orcidid><orcidid>https://orcid.org/0000-0001-7712-9628</orcidid></search><sort><creationdate>202110</creationdate><title>History of depression is associated with worsened postoperative outcomes following colectomy</title><author>Zhang, George Q. ; Canner, Joseph K. ; Prince, Elizabeth J. ; Stem, Miloslawa ; Taylor, James P. ; Efron, Jonathan E. ; Atallah, Chady ; Safar, Bashar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3290-aeb249c84b7014182e3235f944b21a6b1065d40469d376fb32a4808c5914a5d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>colectomy</topic><topic>Colorectal surgery</topic><topic>Complications</topic><topic>depression</topic><topic>Diagnosis</topic><topic>length of stay</topic><topic>Mental depression</topic><topic>mental health</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Patients</topic><topic>Postoperative</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, George Q.</creatorcontrib><creatorcontrib>Canner, Joseph K.</creatorcontrib><creatorcontrib>Prince, Elizabeth J.</creatorcontrib><creatorcontrib>Stem, Miloslawa</creatorcontrib><creatorcontrib>Taylor, James P.</creatorcontrib><creatorcontrib>Efron, Jonathan E.</creatorcontrib><creatorcontrib>Atallah, Chady</creatorcontrib><creatorcontrib>Safar, Bashar</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley-Blackwell Open Access Backfiles</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, George Q.</au><au>Canner, Joseph K.</au><au>Prince, Elizabeth J.</au><au>Stem, Miloslawa</au><au>Taylor, James P.</au><au>Efron, Jonathan E.</au><au>Atallah, Chady</au><au>Safar, Bashar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>History of depression is associated with worsened postoperative outcomes following colectomy</atitle><jtitle>Colorectal disease</jtitle><date>2021-10</date><risdate>2021</risdate><volume>23</volume><issue>10</issue><spage>2559</spage><epage>2566</epage><pages>2559-2566</pages><issn>1462-8910</issn><eissn>1463-1318</eissn><abstract>Aim
Depression is a prevalent disorder that is associated with adverse health outcomes, but an understanding of its effect in colorectal surgery remains limited. The purpose of this study was to examine the impact of history of depression among patients undergoing colectomy.
Method
United States patients from Marketscan (2010–2017) who underwent colectomy were included and stratified by whether they had a history of depression within the past year, defined as (1) a diagnosis of depression during the index admission, (2) a diagnosis of depression during any inpatient or (3) outpatient admission within the year, and/or (4) a pharmacy claim for an antidepressant within the year. The primary outcomes were length of stay (LOS) and inpatient hospital charge. Secondary outcomes included in‐hospital mortality and postoperative complications. Logistic, negative binomial, and quantile regressions were performed.
Results
Among 88 981 patients, 21 878 (24.6%) had a history of depression. Compared to those without, patients with a history of depression had significantly longer LOS (IRR = 1.06, 95% CI [1.05, 1.07]), increased inpatient charge (β = 467, 95% CI [167, 767]), and increased odds of in‐hospital mortality (OR = 1.37, 95% CI [1.08, 1.73]) after adjustment. History of depression was also independently associated with increased odds of respiratory complication, pneumonia, and delirium (all P < 0.05).
Conclusion
History of depression was prevalent among individuals undergoing colectomy, and associated with greater mortality and inpatient charge, longer LOS, and higher odds of postoperative complication. These findings highlight the impact of depression in colorectal surgery patients and suggest that proper identification and treatment may reduce postoperative morbidity.</abstract><cop>Chichester</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/codi.15790</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0623-6271</orcidid><orcidid>https://orcid.org/0000-0001-7712-9628</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | colectomy Colorectal surgery Complications depression Diagnosis length of stay Mental depression mental health Morbidity Mortality Patients Postoperative Surgery |
| title | History of depression is associated with worsened postoperative outcomes following colectomy |
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