Genetic animal models of scoliosis: A systematical review
Scoliosis is a complex disease with undetermined pathogenesis and has a strong relationship with genetics. Models of scoliosis in animals have been established for better comprehending its pathogenesis and treatment. In this review, we searched all the genetic animal models with body curvature in da...
Gespeichert in:
| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2021-11, Vol.152, p.116075-116075, Article 116075 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 116075 |
|---|---|
| container_issue | |
| container_start_page | 116075 |
| container_title | Bone (New York, N.Y.) |
| container_volume | 152 |
| creator | Lv, Xin Xu, Jinghong Jiang, Jiajiong Wu, Pengfei Tan, Renchun Wang, Bing |
| description | Scoliosis is a complex disease with undetermined pathogenesis and has a strong relationship with genetics. Models of scoliosis in animals have been established for better comprehending its pathogenesis and treatment. In this review, we searched all the genetic animal models with body curvature in databases, and reviewed the related genes and scoliosis types. Meanwhile, we also summarized the pathogenesis of scoliosis reported so far. Summarizing the positive phenotypic animal models contributes to a better understanding on the pathogenesis of scoliosis and facilitates the selection of experimental models when a possible pathogenic factor is concerned.
•Genetic animal models of scoliosis in the past were reviewed and discussed according to the mechanism.•The pathological processes in scoliosis were summarized to provide ideas for exploring the pathogenesis of scoliosis.•Analyzed the relationship between animal phenotypes and scoliosis types to provide reference for how to select model animals. |
| doi_str_mv | 10.1016/j.bone.2021.116075 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2545599684</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S8756328221002374</els_id><sourcerecordid>2545599684</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-52445ae7dfb15e7a400d689900471b22672220fc6bda4207038bf6dc283086973</originalsourceid><addsrcrecordid>eNp9kEtLxDAURoMoOI7-AVddumm9SZpHxc0w-IIBN7oOaXoLGdpmTDrK_Htb6trV3ZzvwjmE3FIoKFB5vy_qMGDBgNGCUglKnJEV1YrnTEl-TlZaCZlzptkluUppDwC8UnRFqhcccPQus4PvbZf1ocEuZaHNkgudD8mnh2yTpVMasbcTODERvz3-XJOL1nYJb_7umnw-P31sX_Pd-8vbdrPLHVdqzAUrS2FRNW1NBSpbAjRSVxVAqWjNmFSMMWidrBtbMlDAdd3KxjHNQctK8TW5W_4eYvg6YhpN75PDrrMDhmMyTJRCVJXU5YSyBXUxpBSxNYc4WcWToWDmTmZv5k5m7mSWTtPocRlN3rNYNMl5HBw2PqIbTRP8f_NfKRJvFg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2545599684</pqid></control><display><type>article</type><title>Genetic animal models of scoliosis: A systematical review</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Lv, Xin ; Xu, Jinghong ; Jiang, Jiajiong ; Wu, Pengfei ; Tan, Renchun ; Wang, Bing</creator><creatorcontrib>Lv, Xin ; Xu, Jinghong ; Jiang, Jiajiong ; Wu, Pengfei ; Tan, Renchun ; Wang, Bing</creatorcontrib><description>Scoliosis is a complex disease with undetermined pathogenesis and has a strong relationship with genetics. Models of scoliosis in animals have been established for better comprehending its pathogenesis and treatment. In this review, we searched all the genetic animal models with body curvature in databases, and reviewed the related genes and scoliosis types. Meanwhile, we also summarized the pathogenesis of scoliosis reported so far. Summarizing the positive phenotypic animal models contributes to a better understanding on the pathogenesis of scoliosis and facilitates the selection of experimental models when a possible pathogenic factor is concerned.
•Genetic animal models of scoliosis in the past were reviewed and discussed according to the mechanism.•The pathological processes in scoliosis were summarized to provide ideas for exploring the pathogenesis of scoliosis.•Analyzed the relationship between animal phenotypes and scoliosis types to provide reference for how to select model animals.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2021.116075</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Animal model ; Developmental abnormality ; Gene ; Pathogenesis ; Scoliosis</subject><ispartof>Bone (New York, N.Y.), 2021-11, Vol.152, p.116075-116075, Article 116075</ispartof><rights>2021 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-52445ae7dfb15e7a400d689900471b22672220fc6bda4207038bf6dc283086973</citedby><cites>FETCH-LOGICAL-c377t-52445ae7dfb15e7a400d689900471b22672220fc6bda4207038bf6dc283086973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bone.2021.116075$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids></links><search><creatorcontrib>Lv, Xin</creatorcontrib><creatorcontrib>Xu, Jinghong</creatorcontrib><creatorcontrib>Jiang, Jiajiong</creatorcontrib><creatorcontrib>Wu, Pengfei</creatorcontrib><creatorcontrib>Tan, Renchun</creatorcontrib><creatorcontrib>Wang, Bing</creatorcontrib><title>Genetic animal models of scoliosis: A systematical review</title><title>Bone (New York, N.Y.)</title><description>Scoliosis is a complex disease with undetermined pathogenesis and has a strong relationship with genetics. Models of scoliosis in animals have been established for better comprehending its pathogenesis and treatment. In this review, we searched all the genetic animal models with body curvature in databases, and reviewed the related genes and scoliosis types. Meanwhile, we also summarized the pathogenesis of scoliosis reported so far. Summarizing the positive phenotypic animal models contributes to a better understanding on the pathogenesis of scoliosis and facilitates the selection of experimental models when a possible pathogenic factor is concerned.
•Genetic animal models of scoliosis in the past were reviewed and discussed according to the mechanism.•The pathological processes in scoliosis were summarized to provide ideas for exploring the pathogenesis of scoliosis.•Analyzed the relationship between animal phenotypes and scoliosis types to provide reference for how to select model animals.</description><subject>Animal model</subject><subject>Developmental abnormality</subject><subject>Gene</subject><subject>Pathogenesis</subject><subject>Scoliosis</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAURoMoOI7-AVddumm9SZpHxc0w-IIBN7oOaXoLGdpmTDrK_Htb6trV3ZzvwjmE3FIoKFB5vy_qMGDBgNGCUglKnJEV1YrnTEl-TlZaCZlzptkluUppDwC8UnRFqhcccPQus4PvbZf1ocEuZaHNkgudD8mnh2yTpVMasbcTODERvz3-XJOL1nYJb_7umnw-P31sX_Pd-8vbdrPLHVdqzAUrS2FRNW1NBSpbAjRSVxVAqWjNmFSMMWidrBtbMlDAdd3KxjHNQctK8TW5W_4eYvg6YhpN75PDrrMDhmMyTJRCVJXU5YSyBXUxpBSxNYc4WcWToWDmTmZv5k5m7mSWTtPocRlN3rNYNMl5HBw2PqIbTRP8f_NfKRJvFg</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Lv, Xin</creator><creator>Xu, Jinghong</creator><creator>Jiang, Jiajiong</creator><creator>Wu, Pengfei</creator><creator>Tan, Renchun</creator><creator>Wang, Bing</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Genetic animal models of scoliosis: A systematical review</title><author>Lv, Xin ; Xu, Jinghong ; Jiang, Jiajiong ; Wu, Pengfei ; Tan, Renchun ; Wang, Bing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-52445ae7dfb15e7a400d689900471b22672220fc6bda4207038bf6dc283086973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal model</topic><topic>Developmental abnormality</topic><topic>Gene</topic><topic>Pathogenesis</topic><topic>Scoliosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lv, Xin</creatorcontrib><creatorcontrib>Xu, Jinghong</creatorcontrib><creatorcontrib>Jiang, Jiajiong</creatorcontrib><creatorcontrib>Wu, Pengfei</creatorcontrib><creatorcontrib>Tan, Renchun</creatorcontrib><creatorcontrib>Wang, Bing</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lv, Xin</au><au>Xu, Jinghong</au><au>Jiang, Jiajiong</au><au>Wu, Pengfei</au><au>Tan, Renchun</au><au>Wang, Bing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic animal models of scoliosis: A systematical review</atitle><jtitle>Bone (New York, N.Y.)</jtitle><date>2021-11</date><risdate>2021</risdate><volume>152</volume><spage>116075</spage><epage>116075</epage><pages>116075-116075</pages><artnum>116075</artnum><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>Scoliosis is a complex disease with undetermined pathogenesis and has a strong relationship with genetics. Models of scoliosis in animals have been established for better comprehending its pathogenesis and treatment. In this review, we searched all the genetic animal models with body curvature in databases, and reviewed the related genes and scoliosis types. Meanwhile, we also summarized the pathogenesis of scoliosis reported so far. Summarizing the positive phenotypic animal models contributes to a better understanding on the pathogenesis of scoliosis and facilitates the selection of experimental models when a possible pathogenic factor is concerned.
•Genetic animal models of scoliosis in the past were reviewed and discussed according to the mechanism.•The pathological processes in scoliosis were summarized to provide ideas for exploring the pathogenesis of scoliosis.•Analyzed the relationship between animal phenotypes and scoliosis types to provide reference for how to select model animals.</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.bone.2021.116075</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8756-3282 |
| ispartof | Bone (New York, N.Y.), 2021-11, Vol.152, p.116075-116075, Article 116075 |
| issn | 8756-3282 1873-2763 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2545599684 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Animal model Developmental abnormality Gene Pathogenesis Scoliosis |
| title | Genetic animal models of scoliosis: A systematical review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T18%3A05%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20animal%20models%20of%20scoliosis:%20A%20systematical%20review&rft.jtitle=Bone%20(New%20York,%20N.Y.)&rft.au=Lv,%20Xin&rft.date=2021-11&rft.volume=152&rft.spage=116075&rft.epage=116075&rft.pages=116075-116075&rft.artnum=116075&rft.issn=8756-3282&rft.eissn=1873-2763&rft_id=info:doi/10.1016/j.bone.2021.116075&rft_dat=%3Cproquest_cross%3E2545599684%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2545599684&rft_id=info:pmid/&rft_els_id=S8756328221002374&rfr_iscdi=true |