Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice

ABSTRACT The remodeling of the extracellular matrix is a central function in endochondral ossification and bone homeostasis. During secondary fracture healing, vascular invasion and bone growth requires the removal of the cartilage intermediate and the coordinate action of the collagenase matrix met...

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Veröffentlicht in:	Journal of bone and mineral research 2021-11, Vol.36 (11), p.2203-2213
Hauptverfasser:	Valdés‐Fernández, José, López‐Martínez, Tania, Ripalda‐Cemboráin, Purificación, Calvo, Isabel A, Sáez, Borja, Romero‐Torrecilla, Juan Antonio, Aldazabal, Javier, Muiños‐López, Emma, Montiel, Verónica, Orbe, Josune, Rodríguez, José Antonio, Páramo, José Antonio, Prósper, Felipe, Granero‐Moltó, Froilán
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BONE FRACTURE Bone growth Bone healing Bone marrow transplantation Bone turnover Cartilage Chondrocytes Collagen Collagenase Endochondral bone ENDOCHONDRAL OSSIFICATION EXTRACELLULAR MATRIX Fracture Healing - genetics Fractures Gelatinase Genotype & phenotype Homeostasis Homology MACROPHAGES Matrix metalloproteinase Matrix Metalloproteinase 10 - genetics Metalloproteinase Mice Mice, Inbred C57BL Mice, Knockout MMP‐10 Ossification Osteogenesis Phenotypes Regeneration Stromelysin Stromelysin 1 Stromelysin 2
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