Disruption of Jmjd3/p16Ink4a Signaling Pathway Causes Bizarre Parosteal Osteochondromatous Proliferation (BPOP)‐like Lesion in Mice

ABSTRACT Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora's lesion, is a rare benign osteochondromatous lesion. At present, the molecular etiology of BPOP remains unclear. JMJD3(KDM6B) is an H3K27me3 demethylase and counteracts polycomb‐mediated transcription repression. Previ...

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Veröffentlicht in:	Journal of bone and mineral research 2021-10, Vol.36 (10), p.1931-1941
Hauptverfasser:	Zhang, Feng, Wang, Yingmei, Wang, Yuying, Wang, Xinli, Zhang, Dawei, Zhao, Xiong, Jiang, Runmin, Gu, Yu, Yang, Guifang, Fu, Xin, Xu, Longyong, Xu, Longxia, Zheng, Liting, Zhang, Jing, Li, Zengshan, Yan, Qingguo, Shi, Jianguo, Roessner, Albert, Wang, Zhe, Li, Qing, Ye, Jing, Chen, Charlie Degui, Guo, Shuangping, Min, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	BIZARRE PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION (BPOP) Etiology Gene silencing Immunohistochemistry INK4 protein INK4a protein JMJD3 Lesions Osteoarthritis p16 Protein p16Ink4a Polycomb group proteins Signal transduction
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