Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress

Cardiac hypertrophy (CH) plays a central role in cardiac remodeling and is an independent risk factor for cardiac events. It is imperative to find drugs with protective effect on CH. Dioscin, one natural product, shows various pharmacological activities, and PKCepsilon (PKCε) plays an important role...

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Veröffentlicht in:	European journal of pharmacology 2021-09, Vol.907, p.174277, Article 174277
Hauptverfasser:	Li, Ruomiao, Qi, Yan, Yuan, Qianhui, Xu, Lina, Gao, Meng, Xu, Youwei, Han, Xu, Yin, Lianhong, Liu, Chuntong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiac hypertrophy Cardiomegaly - chemically induced Cardiomegaly - drug therapy Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomegaly - prevention & control Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Cell Line Dioscin Diosgenin - analogs & derivatives Diosgenin - pharmacology Diosgenin - therapeutic use ERK Extracellular Signal-Regulated MAP Kinases - metabolism Isoproterenol Isoproterenol - toxicity Male MAP Kinase Signaling System - drug effects Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oxidative stress Oxidative Stress - drug effects PKCε signal Protein Kinase C-epsilon - metabolism Rats Rats, Sprague-Dawley
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