Perioperative pharmacokinetic-guided factor VIII concentrate dosing in haemophilia (OPTI-CLOT trial): an open-label, multicentre, randomised, controlled trial

Dosing of replacement therapy with factor VIII concentrate in patients with haemophilia A in the perioperative setting is challenging. Underdosing and overdosing of factor VIII concentrate should be avoided to minimise risk of perioperative bleeding and treatment costs. We hypothesised that dosing o...

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Veröffentlicht in:	The Lancet. Haematology 2021-07, Vol.8 (7), p.e492-e502
Hauptverfasser:	van Moort, Iris, Preijers, Tim, Bukkems, Laura H, Hazendonk, Hendrika C A M, van der Bom, Johanna G, Laros-van Gorkom, Britta A P, Beckers, Erik A M, Nieuwenhuizen, Laurens, van der Meer, Felix J M, Ypma, Paula, Coppens, Michiel, Fijnvandraat, Karin, Schutgens, Roger E G, Meijer, Karina, Leebeek, Frank W G, Mathôt, Ron A A, Cnossen, Marjon H, Cnossen, Marjon H., Leebeek, Frank W.G., Mathôt, Ron A.A., Kruip, Marieke J.H.A., Polinder, Suzanne, Lock, Janske, Hazendonk, Hendrika C.A.M., Van Moort, Iris, Heijdra, Jessica M., Goedhart, Marie C.H.J., Al Arashi, Wala, De Jager, Nico C.B., Bukkems, Laura H., Cloesmeijer, Michael E., Janssen, Alexander, Tamminga, Rienk Y.J., Brons, Paul, Schols, Saskia E.M., Eikenboom, Jeroen C.J., Van der Meer, Felix J.M., Schutgens, Roger E.G., Fischer, Kathelijne, Van Galen, Karin P.M., Beckers, Erik E.A.M., Heubel-Moenen, Floor C.J.I., Driessens, Mariëtte H.E., Van Vliet, Ineke, Collins, Peter W., Liesner, Ri, Chowdary, Pratima, Millar, Carolyn M., Hart, Dan, Keeling, David
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Sprache:	eng
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