Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance

Aldehyde oxidase (AOX) is a soluble, cytosolic enzyme that metabolizes various N-heterocyclic compounds and organic aldehydes. It has wide tissue distribution with highest levels found in liver, kidney, and lung. Human clearance projections of AOX substrates by in vitro assessments in isolated liver...

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Veröffentlicht in:	Drug metabolism and disposition 2021-09, Vol.49 (9), p.743-749
Hauptverfasser:	Kozminski, Kirk D., Selimkhanov, Jangir, Heyward, Scott, Zientek, Michael A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Oxidase - metabolism Aldehydes - metabolism Blood Vessels - enzymology Correlation of Data Enzyme Assays - methods Heterocyclic Compounds - metabolism Humans Intestines - enzymology Kidney - enzymology Liver - enzymology Lung - enzymology Metabolic Clearance Rate Tissue Distribution - physiology
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