Prediagnosis epilepsy and survival in patients with glioma: a nationwide population-based cohort study from 2009 to 2018
Objective Considering that epilepsy is common, and knowledge is lacking on its role especially for the prognosis of high-grade gliomas, the objective of this study was to investigate the association between epilepsy prior to glioma diagnosis and survival among glioma patients. Methods In a nationwid...
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| Veröffentlicht in: | Journal of neurology 2022-02, Vol.269 (2), p.861-872 |
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| container_title | Journal of neurology |
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| creator | Marku, Mirketa Rasmussen, Birthe Krogh Belmonte, Federica Hansen, Steinbjørn Andersen, Elisabeth Anne Wreford Johansen, Christoffer Bidstrup, Pernille Envold |
| description | Objective
Considering that epilepsy is common, and knowledge is lacking on its role especially for the prognosis of high-grade gliomas, the objective of this study was to investigate the association between epilepsy prior to glioma diagnosis and survival among glioma patients.
Methods
In a nationwide population-based cohort study, we included 3763 adult glioma patients diagnosed between 2009 and 2018 according to the Danish Neuro-Oncology Registry. Information on epilepsy was redeemed through Danish Neuro-Oncology Registry, National Patient Registry, and National Prescription Registry. Cox proportional hazard models with 95% confidence intervals (CIs) were applied to examine hazard ratios (HRs) for the association between epilepsy ( |
| doi_str_mv | 10.1007/s00415-021-10668-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2544881053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2621820258</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-a417ed2aa932442d5e72090570490fe15b4d9cb9156ad798426e297239c21bf13</originalsourceid><addsrcrecordid>eNp9kc1u1TAQRi0EoreFF2CBLLFhYxiPfxKzQ1WhSJVgAWvLiZ1bV0kc7KTlvj2mt4DEgtVoZs58tnQIecHhDQdo3hYAyRUD5IyD1i3Tj8iOS4GMS2Uekx0ICUwJJU_IaSk3ANDWxVNyIiTXSmOzIz--5OCj28-pxELDEsewlAN1s6dly7fx1o00znRxawzzWuhdXK_pfoxpcu-oo3Odp_ku-kCXtGzjfcs6V4KnfbpOeaVl3fyBDjlNFAEMXVOtvH1GngxuLOH5Qz0j3z5cfD2_ZFefP346f3_FetGolTnJm-DROSNQSvQqNAgGVAPSwBC46qQ3fWe40s43ppWoA5oGhemRdwMXZ-T1MXfJ6fsWymqnWPowjm4OaSsWlZRty0GJir76B71JW57r7yxq5C0CqrZSeKT6nErJYbBLjpPLB8vB_vJij15s9WLvvVhdj14-RG_dFPyfk98iKiCOQKmreR_y37f_E_sT446XAA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2621820258</pqid></control><display><type>article</type><title>Prediagnosis epilepsy and survival in patients with glioma: a nationwide population-based cohort study from 2009 to 2018</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Marku, Mirketa ; Rasmussen, Birthe Krogh ; Belmonte, Federica ; Hansen, Steinbjørn ; Andersen, Elisabeth Anne Wreford ; Johansen, Christoffer ; Bidstrup, Pernille Envold</creator><creatorcontrib>Marku, Mirketa ; Rasmussen, Birthe Krogh ; Belmonte, Federica ; Hansen, Steinbjørn ; Andersen, Elisabeth Anne Wreford ; Johansen, Christoffer ; Bidstrup, Pernille Envold</creatorcontrib><description>Objective
Considering that epilepsy is common, and knowledge is lacking on its role especially for the prognosis of high-grade gliomas, the objective of this study was to investigate the association between epilepsy prior to glioma diagnosis and survival among glioma patients.
Methods
In a nationwide population-based cohort study, we included 3763 adult glioma patients diagnosed between 2009 and 2018 according to the Danish Neuro-Oncology Registry. Information on epilepsy was redeemed through Danish Neuro-Oncology Registry, National Patient Registry, and National Prescription Registry. Cox proportional hazard models with 95% confidence intervals (CIs) were applied to examine hazard ratios (HRs) for the association between epilepsy (< 1 year prior to glioma including epilepsy at onset; 1–10 years prior to glioma; no prior epilepsy) and risk of death, and whether it differed according to tumor grade and size, performance status, and treatment modalities.
Results
A 32% decreased risk of death in patients with epilepsy within 1 year prior to glioma compared to no prior epilepsy was found (HR = 0.68; CI 0.63–0.75). A favorable prognosis was seen for epilepsy in all glioma grades: II (HR = 0.55; CI 0.39–0.77), III (HR = 0.59; CI 0.48–0.73), and IV (HR = 0.85; CI 0.77–0.94).
Conclusions
Patients with epilepsy within 1 year prior to glioma diagnosis had significant survival benefits compared to patients with no prior epilepsy. This association was significant for both low-grade gliomas (grade II) and high-grade gliomas (grade III and IV). Survival benefits in glioma patients with epilepsy at onset are possibly primarily attributable to tumor-specific histopathology, molecular biomarkers, and early diagnosis.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-021-10668-6</identifier><identifier>PMID: 34165627</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Brain Neoplasms - diagnosis ; Brain Neoplasms - epidemiology ; Brain tumors ; Cohort analysis ; Cohort Studies ; Diagnosis ; Epilepsy ; Epilepsy - epidemiology ; Glioma ; Glioma - complications ; Glioma - diagnosis ; Glioma - epidemiology ; Humans ; Medical prognosis ; Medicine ; Medicine & Public Health ; Neurology ; Neuroradiology ; Neurosciences ; Oncology ; Original Communication ; Patients ; Population studies ; Population-based studies ; Prognosis ; Survival</subject><ispartof>Journal of neurology, 2022-02, Vol.269 (2), p.861-872</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a417ed2aa932442d5e72090570490fe15b4d9cb9156ad798426e297239c21bf13</citedby><cites>FETCH-LOGICAL-c375t-a417ed2aa932442d5e72090570490fe15b4d9cb9156ad798426e297239c21bf13</cites><orcidid>0000-0002-8619-8032</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-021-10668-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-021-10668-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34165627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marku, Mirketa</creatorcontrib><creatorcontrib>Rasmussen, Birthe Krogh</creatorcontrib><creatorcontrib>Belmonte, Federica</creatorcontrib><creatorcontrib>Hansen, Steinbjørn</creatorcontrib><creatorcontrib>Andersen, Elisabeth Anne Wreford</creatorcontrib><creatorcontrib>Johansen, Christoffer</creatorcontrib><creatorcontrib>Bidstrup, Pernille Envold</creatorcontrib><title>Prediagnosis epilepsy and survival in patients with glioma: a nationwide population-based cohort study from 2009 to 2018</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Objective
Considering that epilepsy is common, and knowledge is lacking on its role especially for the prognosis of high-grade gliomas, the objective of this study was to investigate the association between epilepsy prior to glioma diagnosis and survival among glioma patients.
Methods
In a nationwide population-based cohort study, we included 3763 adult glioma patients diagnosed between 2009 and 2018 according to the Danish Neuro-Oncology Registry. Information on epilepsy was redeemed through Danish Neuro-Oncology Registry, National Patient Registry, and National Prescription Registry. Cox proportional hazard models with 95% confidence intervals (CIs) were applied to examine hazard ratios (HRs) for the association between epilepsy (< 1 year prior to glioma including epilepsy at onset; 1–10 years prior to glioma; no prior epilepsy) and risk of death, and whether it differed according to tumor grade and size, performance status, and treatment modalities.
Results
A 32% decreased risk of death in patients with epilepsy within 1 year prior to glioma compared to no prior epilepsy was found (HR = 0.68; CI 0.63–0.75). A favorable prognosis was seen for epilepsy in all glioma grades: II (HR = 0.55; CI 0.39–0.77), III (HR = 0.59; CI 0.48–0.73), and IV (HR = 0.85; CI 0.77–0.94).
Conclusions
Patients with epilepsy within 1 year prior to glioma diagnosis had significant survival benefits compared to patients with no prior epilepsy. This association was significant for both low-grade gliomas (grade II) and high-grade gliomas (grade III and IV). Survival benefits in glioma patients with epilepsy at onset are possibly primarily attributable to tumor-specific histopathology, molecular biomarkers, and early diagnosis.</description><subject>Adult</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - epidemiology</subject><subject>Brain tumors</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Diagnosis</subject><subject>Epilepsy</subject><subject>Epilepsy - epidemiology</subject><subject>Glioma</subject><subject>Glioma - complications</subject><subject>Glioma - diagnosis</subject><subject>Glioma - epidemiology</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Oncology</subject><subject>Original Communication</subject><subject>Patients</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Prognosis</subject><subject>Survival</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1u1TAQRi0EoreFF2CBLLFhYxiPfxKzQ1WhSJVgAWvLiZ1bV0kc7KTlvj2mt4DEgtVoZs58tnQIecHhDQdo3hYAyRUD5IyD1i3Tj8iOS4GMS2Uekx0ICUwJJU_IaSk3ANDWxVNyIiTXSmOzIz--5OCj28-pxELDEsewlAN1s6dly7fx1o00znRxawzzWuhdXK_pfoxpcu-oo3Odp_ku-kCXtGzjfcs6V4KnfbpOeaVl3fyBDjlNFAEMXVOtvH1GngxuLOH5Qz0j3z5cfD2_ZFefP346f3_FetGolTnJm-DROSNQSvQqNAgGVAPSwBC46qQ3fWe40s43ppWoA5oGhemRdwMXZ-T1MXfJ6fsWymqnWPowjm4OaSsWlZRty0GJir76B71JW57r7yxq5C0CqrZSeKT6nErJYbBLjpPLB8vB_vJij15s9WLvvVhdj14-RG_dFPyfk98iKiCOQKmreR_y37f_E_sT446XAA</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Marku, Mirketa</creator><creator>Rasmussen, Birthe Krogh</creator><creator>Belmonte, Federica</creator><creator>Hansen, Steinbjørn</creator><creator>Andersen, Elisabeth Anne Wreford</creator><creator>Johansen, Christoffer</creator><creator>Bidstrup, Pernille Envold</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8619-8032</orcidid></search><sort><creationdate>20220201</creationdate><title>Prediagnosis epilepsy and survival in patients with glioma: a nationwide population-based cohort study from 2009 to 2018</title><author>Marku, Mirketa ; Rasmussen, Birthe Krogh ; Belmonte, Federica ; Hansen, Steinbjørn ; Andersen, Elisabeth Anne Wreford ; Johansen, Christoffer ; Bidstrup, Pernille Envold</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a417ed2aa932442d5e72090570490fe15b4d9cb9156ad798426e297239c21bf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - epidemiology</topic><topic>Brain tumors</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Diagnosis</topic><topic>Epilepsy</topic><topic>Epilepsy - epidemiology</topic><topic>Glioma</topic><topic>Glioma - complications</topic><topic>Glioma - diagnosis</topic><topic>Glioma - epidemiology</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Oncology</topic><topic>Original Communication</topic><topic>Patients</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Prognosis</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marku, Mirketa</creatorcontrib><creatorcontrib>Rasmussen, Birthe Krogh</creatorcontrib><creatorcontrib>Belmonte, Federica</creatorcontrib><creatorcontrib>Hansen, Steinbjørn</creatorcontrib><creatorcontrib>Andersen, Elisabeth Anne Wreford</creatorcontrib><creatorcontrib>Johansen, Christoffer</creatorcontrib><creatorcontrib>Bidstrup, Pernille Envold</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marku, Mirketa</au><au>Rasmussen, Birthe Krogh</au><au>Belmonte, Federica</au><au>Hansen, Steinbjørn</au><au>Andersen, Elisabeth Anne Wreford</au><au>Johansen, Christoffer</au><au>Bidstrup, Pernille Envold</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediagnosis epilepsy and survival in patients with glioma: a nationwide population-based cohort study from 2009 to 2018</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>269</volume><issue>2</issue><spage>861</spage><epage>872</epage><pages>861-872</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Objective
Considering that epilepsy is common, and knowledge is lacking on its role especially for the prognosis of high-grade gliomas, the objective of this study was to investigate the association between epilepsy prior to glioma diagnosis and survival among glioma patients.
Methods
In a nationwide population-based cohort study, we included 3763 adult glioma patients diagnosed between 2009 and 2018 according to the Danish Neuro-Oncology Registry. Information on epilepsy was redeemed through Danish Neuro-Oncology Registry, National Patient Registry, and National Prescription Registry. Cox proportional hazard models with 95% confidence intervals (CIs) were applied to examine hazard ratios (HRs) for the association between epilepsy (< 1 year prior to glioma including epilepsy at onset; 1–10 years prior to glioma; no prior epilepsy) and risk of death, and whether it differed according to tumor grade and size, performance status, and treatment modalities.
Results
A 32% decreased risk of death in patients with epilepsy within 1 year prior to glioma compared to no prior epilepsy was found (HR = 0.68; CI 0.63–0.75). A favorable prognosis was seen for epilepsy in all glioma grades: II (HR = 0.55; CI 0.39–0.77), III (HR = 0.59; CI 0.48–0.73), and IV (HR = 0.85; CI 0.77–0.94).
Conclusions
Patients with epilepsy within 1 year prior to glioma diagnosis had significant survival benefits compared to patients with no prior epilepsy. This association was significant for both low-grade gliomas (grade II) and high-grade gliomas (grade III and IV). Survival benefits in glioma patients with epilepsy at onset are possibly primarily attributable to tumor-specific histopathology, molecular biomarkers, and early diagnosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34165627</pmid><doi>10.1007/s00415-021-10668-6</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8619-8032</orcidid></addata></record> |
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| subjects | Adult Brain Neoplasms - diagnosis Brain Neoplasms - epidemiology Brain tumors Cohort analysis Cohort Studies Diagnosis Epilepsy Epilepsy - epidemiology Glioma Glioma - complications Glioma - diagnosis Glioma - epidemiology Humans Medical prognosis Medicine Medicine & Public Health Neurology Neuroradiology Neurosciences Oncology Original Communication Patients Population studies Population-based studies Prognosis Survival |
| title | Prediagnosis epilepsy and survival in patients with glioma: a nationwide population-based cohort study from 2009 to 2018 |
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