Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration
Purpose To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged. Method The medical charts of 95...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2021-12, Vol.259 (12), p.3589-3596 |
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| creator | Kaneko, Hiroki Takashi, Noriko Matsunaga, Masaaki Ito, Yasuki Takeuchi, Jun Terasaki, Hiroko Yatsuya, Hiroshi Nishiguchi, Koji M. |
| description | Purpose
To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged.
Method
The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012–2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded.
Results
The monthly numbers of cases of SMHs caused by AMD from January to December were 6, 8, 4, 9, 7, 10, 9, 11, 7, 11, 3, and 10. No significant seasonal variation in the monthly incidence was identified (Roger’s R = 1.89, p = 0.39). The monthly numbers of SMHs caused by RMAs from January to December were 3, 11, 11, 8, 7, 8, 5, 5, 2, 4, 7, and 5. There was significant seasonal variation in the monthly incidence (Roger’s R = 7.67, p = 0.02). There was no significant correlation between the monthly incidence of SMHs caused by RMAs and mean ambient temperature.
Conclusion
Our previous study conducted for cases obtained in 1998–2005 showed seasonal cyclic trend in the number of SMHs caused by AMD, with the peak in winter. However, that significant seasonal variation disappeared in 2012–2019 in the present study. Common usage of OCT devices and anti-VEGF drugs might be the reason for the lack of seasonal variation in the cases of SMH caused by AMD. |
| doi_str_mv | 10.1007/s00417-021-05280-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2544877884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2544877884</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-36c5bad9c1cb5491e8ad1c8f235fb272e7b6ac45f394eacc5caec834b49411c13</originalsourceid><addsrcrecordid>eNp9kTtLxUAQhRdR8Pr4A1YBG5voPpNNKeILBAsVbrdMNpNrJI_rTiLY-dPdeBXBwmqK850zzBzGjgQ_FZznZ8S5FnnKpUi5kZanaosthFYmzblcbrMFz6NklVzusj2iFx55ZcSCfTwg0NBDm7xBaGBshj5p-oSmsgM_tRCSZ-yGEJ5hhTQrAcdmxqMcBuhxCu_UUQJ9lTQjJVVDsF4jBOg9znz0pQFbGLFKfiIrXGGP4WvbAdupoSU8_J777Onq8vHiJr27v769OL9LvRZ2TFXmTQlV4YUvjS4EWqiEt7VUpi5lLjEvM_Da1KrQCN4bD-it0qUutBBeqH12ssldh-F1Qhpd15DHto03DBM5abS2eW6tjujxH_RlmEI8eqaKzIpMZzxSckPFPxAFrN06NB2Edye4m0txm1JcLMV9leJUNKmNiSLcrzD8Rv_j-gSfz5LE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2596816460</pqid></control><display><type>article</type><title>Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration</title><source>SpringerNature Complete Journals</source><creator>Kaneko, Hiroki ; Takashi, Noriko ; Matsunaga, Masaaki ; Ito, Yasuki ; Takeuchi, Jun ; Terasaki, Hiroko ; Yatsuya, Hiroshi ; Nishiguchi, Koji M.</creator><creatorcontrib>Kaneko, Hiroki ; Takashi, Noriko ; Matsunaga, Masaaki ; Ito, Yasuki ; Takeuchi, Jun ; Terasaki, Hiroko ; Yatsuya, Hiroshi ; Nishiguchi, Koji M.</creatorcontrib><description>Purpose
To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged.
Method
The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012–2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded.
Results
The monthly numbers of cases of SMHs caused by AMD from January to December were 6, 8, 4, 9, 7, 10, 9, 11, 7, 11, 3, and 10. No significant seasonal variation in the monthly incidence was identified (Roger’s R = 1.89, p = 0.39). The monthly numbers of SMHs caused by RMAs from January to December were 3, 11, 11, 8, 7, 8, 5, 5, 2, 4, 7, and 5. There was significant seasonal variation in the monthly incidence (Roger’s R = 7.67, p = 0.02). There was no significant correlation between the monthly incidence of SMHs caused by RMAs and mean ambient temperature.
Conclusion
Our previous study conducted for cases obtained in 1998–2005 showed seasonal cyclic trend in the number of SMHs caused by AMD, with the peak in winter. However, that significant seasonal variation disappeared in 2012–2019 in the present study. Common usage of OCT devices and anti-VEGF drugs might be the reason for the lack of seasonal variation in the cases of SMH caused by AMD.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-021-05280-3</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Age ; Macular degeneration ; Medicine ; Medicine & Public Health ; Ophthalmology ; Patients ; Retina ; Retinal Disorders ; Seasonal variations ; Vascular endothelial growth factor ; Winter</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2021-12, Vol.259 (12), p.3589-3596</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-36c5bad9c1cb5491e8ad1c8f235fb272e7b6ac45f394eacc5caec834b49411c13</citedby><cites>FETCH-LOGICAL-c418t-36c5bad9c1cb5491e8ad1c8f235fb272e7b6ac45f394eacc5caec834b49411c13</cites><orcidid>0000-0003-0731-6465</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-021-05280-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-021-05280-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Kaneko, Hiroki</creatorcontrib><creatorcontrib>Takashi, Noriko</creatorcontrib><creatorcontrib>Matsunaga, Masaaki</creatorcontrib><creatorcontrib>Ito, Yasuki</creatorcontrib><creatorcontrib>Takeuchi, Jun</creatorcontrib><creatorcontrib>Terasaki, Hiroko</creatorcontrib><creatorcontrib>Yatsuya, Hiroshi</creatorcontrib><creatorcontrib>Nishiguchi, Koji M.</creatorcontrib><title>Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged.
Method
The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012–2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded.
Results
The monthly numbers of cases of SMHs caused by AMD from January to December were 6, 8, 4, 9, 7, 10, 9, 11, 7, 11, 3, and 10. No significant seasonal variation in the monthly incidence was identified (Roger’s R = 1.89, p = 0.39). The monthly numbers of SMHs caused by RMAs from January to December were 3, 11, 11, 8, 7, 8, 5, 5, 2, 4, 7, and 5. There was significant seasonal variation in the monthly incidence (Roger’s R = 7.67, p = 0.02). There was no significant correlation between the monthly incidence of SMHs caused by RMAs and mean ambient temperature.
Conclusion
Our previous study conducted for cases obtained in 1998–2005 showed seasonal cyclic trend in the number of SMHs caused by AMD, with the peak in winter. However, that significant seasonal variation disappeared in 2012–2019 in the present study. Common usage of OCT devices and anti-VEGF drugs might be the reason for the lack of seasonal variation in the cases of SMH caused by AMD.</description><subject>Age</subject><subject>Macular degeneration</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Retina</subject><subject>Retinal Disorders</subject><subject>Seasonal variations</subject><subject>Vascular endothelial growth factor</subject><subject>Winter</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kTtLxUAQhRdR8Pr4A1YBG5voPpNNKeILBAsVbrdMNpNrJI_rTiLY-dPdeBXBwmqK850zzBzGjgQ_FZznZ8S5FnnKpUi5kZanaosthFYmzblcbrMFz6NklVzusj2iFx55ZcSCfTwg0NBDm7xBaGBshj5p-oSmsgM_tRCSZ-yGEJ5hhTQrAcdmxqMcBuhxCu_UUQJ9lTQjJVVDsF4jBOg9znz0pQFbGLFKfiIrXGGP4WvbAdupoSU8_J777Onq8vHiJr27v769OL9LvRZ2TFXmTQlV4YUvjS4EWqiEt7VUpi5lLjEvM_Da1KrQCN4bD-it0qUutBBeqH12ssldh-F1Qhpd15DHto03DBM5abS2eW6tjujxH_RlmEI8eqaKzIpMZzxSckPFPxAFrN06NB2Edye4m0txm1JcLMV9leJUNKmNiSLcrzD8Rv_j-gSfz5LE</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Kaneko, Hiroki</creator><creator>Takashi, Noriko</creator><creator>Matsunaga, Masaaki</creator><creator>Ito, Yasuki</creator><creator>Takeuchi, Jun</creator><creator>Terasaki, Hiroko</creator><creator>Yatsuya, Hiroshi</creator><creator>Nishiguchi, Koji M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0731-6465</orcidid></search><sort><creationdate>20211201</creationdate><title>Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration</title><author>Kaneko, Hiroki ; Takashi, Noriko ; Matsunaga, Masaaki ; Ito, Yasuki ; Takeuchi, Jun ; Terasaki, Hiroko ; Yatsuya, Hiroshi ; Nishiguchi, Koji M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-36c5bad9c1cb5491e8ad1c8f235fb272e7b6ac45f394eacc5caec834b49411c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Macular degeneration</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Retina</topic><topic>Retinal Disorders</topic><topic>Seasonal variations</topic><topic>Vascular endothelial growth factor</topic><topic>Winter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaneko, Hiroki</creatorcontrib><creatorcontrib>Takashi, Noriko</creatorcontrib><creatorcontrib>Matsunaga, Masaaki</creatorcontrib><creatorcontrib>Ito, Yasuki</creatorcontrib><creatorcontrib>Takeuchi, Jun</creatorcontrib><creatorcontrib>Terasaki, Hiroko</creatorcontrib><creatorcontrib>Yatsuya, Hiroshi</creatorcontrib><creatorcontrib>Nishiguchi, Koji M.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaneko, Hiroki</au><au>Takashi, Noriko</au><au>Matsunaga, Masaaki</au><au>Ito, Yasuki</au><au>Takeuchi, Jun</au><au>Terasaki, Hiroko</au><au>Yatsuya, Hiroshi</au><au>Nishiguchi, Koji M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><date>2021-12-01</date><risdate>2021</risdate><volume>259</volume><issue>12</issue><spage>3589</spage><epage>3596</epage><pages>3589-3596</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged.
Method
The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012–2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded.
Results
The monthly numbers of cases of SMHs caused by AMD from January to December were 6, 8, 4, 9, 7, 10, 9, 11, 7, 11, 3, and 10. No significant seasonal variation in the monthly incidence was identified (Roger’s R = 1.89, p = 0.39). The monthly numbers of SMHs caused by RMAs from January to December were 3, 11, 11, 8, 7, 8, 5, 5, 2, 4, 7, and 5. There was significant seasonal variation in the monthly incidence (Roger’s R = 7.67, p = 0.02). There was no significant correlation between the monthly incidence of SMHs caused by RMAs and mean ambient temperature.
Conclusion
Our previous study conducted for cases obtained in 1998–2005 showed seasonal cyclic trend in the number of SMHs caused by AMD, with the peak in winter. However, that significant seasonal variation disappeared in 2012–2019 in the present study. Common usage of OCT devices and anti-VEGF drugs might be the reason for the lack of seasonal variation in the cases of SMH caused by AMD.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00417-021-05280-3</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0731-6465</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2021-12, Vol.259 (12), p.3589-3596 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | SpringerNature Complete Journals |
| subjects | Age Macular degeneration Medicine Medicine & Public Health Ophthalmology Patients Retina Retinal Disorders Seasonal variations Vascular endothelial growth factor Winter |
| title | Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration |
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