Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Photothermal Therapy of Tumors
Specific and effective accumulation of nanoparticles within tumors is highly crucial for precise cancer diagnosis and treatment. Therefore, spatiotemporally manipulating the aggregation of small gold nanoparticles (AuNPs) in a tumor microenvironment is of great significance for enhancing the diagnos...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2021-07, Vol.93 (26), p.9277-9285 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Cheng, Xiaju Zhou, Xiuxia Xu, Jingwei Sun, Rui Xia, Huawei Ding, Jianan Chin, Y. Eugene Chai, Zhifang Shi, Haibin Gao, Mingyuan |
| description | Specific and effective accumulation of nanoparticles within tumors is highly crucial for precise cancer diagnosis and treatment. Therefore, spatiotemporally manipulating the aggregation of small gold nanoparticles (AuNPs) in a tumor microenvironment is of great significance for enhancing the diagnostic and therapeutic efficacy of tumors. Herein, we reported a novel furin enzyme/acidic pH synergistically triggered small AuNP aggregation strategy for activating the photoacoustic (PA) imaging and photothermal (PTT) functions of AuNPs in vivo. Smart gold nanoparticles decorated with furin-cleavable RVRR (Arg-Val-Arg-Arg) peptides (Au-RRVR) were rationally designed and fabricated. Both in vitro and in vivo experiments demonstrated that such Au-RRVR nanoparticles could be simultaneously induced by furin and acidic pH to form large aggregates within tumorous tissue resulting in improved tumor accumulation and retention, which can further activate the PA and PTT effect of AuNPs for sensitive imaging and efficient therapy of tumors. Thus, we believe that this dual-stimuli-responsive aggregation system may offer a universal platform for effective cancer diagnosis and treatment. |
| doi_str_mv | 10.1021/acs.analchem.1c01713 |
| format | Article |
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Eugene ; Chai, Zhifang ; Shi, Haibin ; Gao, Mingyuan</creator><creatorcontrib>Cheng, Xiaju ; Zhou, Xiuxia ; Xu, Jingwei ; Sun, Rui ; Xia, Huawei ; Ding, Jianan ; Chin, Y. Eugene ; Chai, Zhifang ; Shi, Haibin ; Gao, Mingyuan</creatorcontrib><description>Specific and effective accumulation of nanoparticles within tumors is highly crucial for precise cancer diagnosis and treatment. Therefore, spatiotemporally manipulating the aggregation of small gold nanoparticles (AuNPs) in a tumor microenvironment is of great significance for enhancing the diagnostic and therapeutic efficacy of tumors. Herein, we reported a novel furin enzyme/acidic pH synergistically triggered small AuNP aggregation strategy for activating the photoacoustic (PA) imaging and photothermal (PTT) functions of AuNPs in vivo. Smart gold nanoparticles decorated with furin-cleavable RVRR (Arg-Val-Arg-Arg) peptides (Au-RRVR) were rationally designed and fabricated. Both in vitro and in vivo experiments demonstrated that such Au-RRVR nanoparticles could be simultaneously induced by furin and acidic pH to form large aggregates within tumorous tissue resulting in improved tumor accumulation and retention, which can further activate the PA and PTT effect of AuNPs for sensitive imaging and efficient therapy of tumors. Thus, we believe that this dual-stimuli-responsive aggregation system may offer a universal platform for effective cancer diagnosis and treatment.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.1c01713</identifier><language>eng</language><publisher>Washington: American Chemical Society</publisher><subject>Accumulation ; Agglomeration ; Analytical chemistry ; Cancer ; Chemistry ; Diagnosis ; Enzymes ; Furin ; Gold ; Medical diagnosis ; Medical imaging ; Nanoparticles ; Peptides ; pH effects ; Tumor microenvironment ; Tumors</subject><ispartof>Analytical chemistry (Washington), 2021-07, Vol.93 (26), p.9277-9285</ispartof><rights>2021 American Chemical Society</rights><rights>Copyright American Chemical Society Jul 6, 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a353t-9c3996afc98c2aadcee99822d34c5195acf6e76ddf9b4a9df835cda0e8e3bfc83</citedby><cites>FETCH-LOGICAL-a353t-9c3996afc98c2aadcee99822d34c5195acf6e76ddf9b4a9df835cda0e8e3bfc83</cites><orcidid>0000-0003-2234-9126 ; 0000-0002-7360-3684</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.1c01713$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.1c01713$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,781,785,2766,27078,27926,27927,56740,56790</link.rule.ids></links><search><creatorcontrib>Cheng, Xiaju</creatorcontrib><creatorcontrib>Zhou, Xiuxia</creatorcontrib><creatorcontrib>Xu, Jingwei</creatorcontrib><creatorcontrib>Sun, Rui</creatorcontrib><creatorcontrib>Xia, Huawei</creatorcontrib><creatorcontrib>Ding, Jianan</creatorcontrib><creatorcontrib>Chin, Y. Eugene</creatorcontrib><creatorcontrib>Chai, Zhifang</creatorcontrib><creatorcontrib>Shi, Haibin</creatorcontrib><creatorcontrib>Gao, Mingyuan</creatorcontrib><title>Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Photothermal Therapy of Tumors</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>Specific and effective accumulation of nanoparticles within tumors is highly crucial for precise cancer diagnosis and treatment. Therefore, spatiotemporally manipulating the aggregation of small gold nanoparticles (AuNPs) in a tumor microenvironment is of great significance for enhancing the diagnostic and therapeutic efficacy of tumors. Herein, we reported a novel furin enzyme/acidic pH synergistically triggered small AuNP aggregation strategy for activating the photoacoustic (PA) imaging and photothermal (PTT) functions of AuNPs in vivo. Smart gold nanoparticles decorated with furin-cleavable RVRR (Arg-Val-Arg-Arg) peptides (Au-RRVR) were rationally designed and fabricated. Both in vitro and in vivo experiments demonstrated that such Au-RRVR nanoparticles could be simultaneously induced by furin and acidic pH to form large aggregates within tumorous tissue resulting in improved tumor accumulation and retention, which can further activate the PA and PTT effect of AuNPs for sensitive imaging and efficient therapy of tumors. Thus, we believe that this dual-stimuli-responsive aggregation system may offer a universal platform for effective cancer diagnosis and treatment.</description><subject>Accumulation</subject><subject>Agglomeration</subject><subject>Analytical chemistry</subject><subject>Cancer</subject><subject>Chemistry</subject><subject>Diagnosis</subject><subject>Enzymes</subject><subject>Furin</subject><subject>Gold</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Nanoparticles</subject><subject>Peptides</subject><subject>pH effects</subject><subject>Tumor microenvironment</subject><subject>Tumors</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kbtu3DAQRYkgAbJx8gcpCKRJozUferFcGH4Bhm3Am1oY86GlQZEKKQWQPyTfG8rrpHCRaop77p3BXIS-UrKlhNFTkGkLHpw86GFLJaEN5e_QhlaMFHXbsvdoQwjhBWsI-Yg-pfRECKWE1hv0-2KO1uNz_7wMGoNXeLzCD4vXsbdpshKcW_A-2r7XUSu86_uoe5hs8DgYfBmcwrfgwwgxw04nbELEOznZXzBl_v4QpgAyzGsWvh6gt75_WfOiTAcdB3B4nyeMyxq5n4cQ02f0wYBL-svrPEE_Ls73Z1fFzd3l9dnupgBe8akQkgtRg5GilQxASa2FaBlTvJQVFRVIU-umVsqIxxKEMi2vpAKiW80fjWz5Cfp-zB1j-DnrNHWDTVI7B17noztWlWVZs6bhGf32Bn0Kc8xfX6mKUVZWjchUeaRkDClFbbox2gHi0lHSrWV1uazub1nda1nZRo62Vf2X-1_LHwNZn5Y</recordid><startdate>20210706</startdate><enddate>20210706</enddate><creator>Cheng, Xiaju</creator><creator>Zhou, Xiuxia</creator><creator>Xu, Jingwei</creator><creator>Sun, Rui</creator><creator>Xia, Huawei</creator><creator>Ding, Jianan</creator><creator>Chin, Y. Eugene</creator><creator>Chai, Zhifang</creator><creator>Shi, Haibin</creator><creator>Gao, Mingyuan</creator><general>American Chemical Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2234-9126</orcidid><orcidid>https://orcid.org/0000-0002-7360-3684</orcidid></search><sort><creationdate>20210706</creationdate><title>Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Photothermal Therapy of Tumors</title><author>Cheng, Xiaju ; Zhou, Xiuxia ; Xu, Jingwei ; Sun, Rui ; Xia, Huawei ; Ding, Jianan ; Chin, Y. 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| source | American Chemical Society Journals |
| subjects | Accumulation Agglomeration Analytical chemistry Cancer Chemistry Diagnosis Enzymes Furin Gold Medical diagnosis Medical imaging Nanoparticles Peptides pH effects Tumor microenvironment Tumors |
| title | Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Photothermal Therapy of Tumors |
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