Structure of an open conformation of T7 DNA polymerase reveals novel structural features regulating primer-template stabilization at the polymerization active site

The crystal structure of full-length T7 DNA polymerase in complex with its processivity factor thioredoxin and double-stranded DNA in the polymerization active site exhibits two novel structural motifs in family-A DNA polymerases: an extended β-hairpin at the fingers subdomain, that interacts with t...

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Veröffentlicht in:	Biochemical journal 2021-07, Vol.478 (13), p.2665-2679
Hauptverfasser:	Juarez-Quintero, Víctor, Peralta-Castro, Antolín, Benítez Cardoza, Claudia G., Ellenberger, Tom, Brieba, Luis G.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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