Correlation of tumour and treatment characteristics to dose received by cochlea in volumetric arc therapy
Purpose This is a radiation field simulation study using CT images designed to see the cochlear dosimetry and its correlation with tumour and treatment characteristics during radiotherapy for head and neck cancers (HNC) for identifying the factors associated with a higher dose delivered to the cochl...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2022-04, Vol.279 (4), p.2019-2028 |
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| container_title | European archives of oto-rhino-laryngology |
| container_volume | 279 |
| creator | Das, Nidhin Patro, Sourabha Kumar Kaushal, Darwin Pareek, Puneet Dixit, Abhinav Kombathula, Sri Harsha Soni, Kapil Sharma, Vidhu Goyal, Amit |
| description | Purpose
This is a radiation field simulation study using CT images designed to see the cochlear dosimetry and its correlation with tumour and treatment characteristics during radiotherapy for head and neck cancers (HNC) for identifying the factors associated with a higher dose delivered to the cochlea.
Methods
From 2018 to 2020, 80 patients with HNC underwent volumetric arc therapy (VMAT) to a dose of 66–70 Gy at 2 Gy per fraction with bilateral cochlea contoured for VMAT optimization as an organ at risk. Minimum, mean and maximum planned radiation dose to the cochlea based on tumour and treatment characteristics and dose-volume histogram variables of VMAT plans were analysed.
Results
Mean (standard deviation, SD) cochlear volume was 0.14 (0.06) cm
3
with maximum and mean planned doses of 10.3 (SD = 11.6) Gy and 8.5 (SD = 9.8) Gy, respectively. We found a statistically significant correlation between mean dose received by bilateral cochlea (
P
—0.000,
r
r
ight
—0.84,
r
left
—0.78,
r
midline
—0.92). Tumours of the paranasal sinuses, and the parotids and more advanced T stages were associated with a higher mean dose to cochlea but was not significant statistically. The dose received by the 95% target nodal volume (D
95%
) showed a significant correlation with the cochlear mean dose (
P
—0.000,
r
right
—0.85,
r
left
—0.77,
r
midline
—0.93)
Conclusion
With VMAT we have achieved a better sparing of cochlea. The mean dose to the cochlea of one side significantly differed from the other side in patients with lateralized cancers. D
95%
of nodal volume also showed a significant correlation with the cochlear mean dose. |
| doi_str_mv | 10.1007/s00405-021-06950-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2544459000</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2544459000</sourcerecordid><originalsourceid>FETCH-LOGICAL-c298t-c81d712cfec00fa99c5c96ec27223b6dd7f8028e66ab0f0a59142e6b2868234b3</originalsourceid><addsrcrecordid>eNp9kLtu3DAQRYkgRrxe-wdSGCzTyBlSFCWWwSJ-AAukSWqCGo28XEjimqQM6O-jeJ2Uqaa4515gDmOfBdwJgPprAlBQFSBFAdpUUCwf2EaoUhWqlvoj24Ap60Kpur5kVykdAaBSpvzELkslNGhdbZjfhRhpcNmHiYee53kMc-Ru6niO5PJIU-Z4cNFhpuhT9ph4DrwLiXgkJP9KHW8XjgEPAznuJ_4ahnmkHD1yF5HnA0V3Wq7ZRe-GRDfvd8t-3X__uXss9j8ennbf9gVK0-QCG9HVQmJPCNA7Y7BCowllLWXZ6q6r-wZkQ1q7FnpwlRFKkm5loxtZqrbcsi_n3VMMLzOlbEefkIbBTRTmZGWllKrMKmNF5RnFGFKK1NtT9KOLixVg_yi2Z8V2VWzfFNtlLd2-78_tSN2_yl-nK1CegbRG0zNFe1yVTuvP_5v9DcT4iSc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2544459000</pqid></control><display><type>article</type><title>Correlation of tumour and treatment characteristics to dose received by cochlea in volumetric arc therapy</title><source>SpringerLink Journals</source><creator>Das, Nidhin ; Patro, Sourabha Kumar ; Kaushal, Darwin ; Pareek, Puneet ; Dixit, Abhinav ; Kombathula, Sri Harsha ; Soni, Kapil ; Sharma, Vidhu ; Goyal, Amit</creator><creatorcontrib>Das, Nidhin ; Patro, Sourabha Kumar ; Kaushal, Darwin ; Pareek, Puneet ; Dixit, Abhinav ; Kombathula, Sri Harsha ; Soni, Kapil ; Sharma, Vidhu ; Goyal, Amit</creatorcontrib><description>Purpose
This is a radiation field simulation study using CT images designed to see the cochlear dosimetry and its correlation with tumour and treatment characteristics during radiotherapy for head and neck cancers (HNC) for identifying the factors associated with a higher dose delivered to the cochlea.
Methods
From 2018 to 2020, 80 patients with HNC underwent volumetric arc therapy (VMAT) to a dose of 66–70 Gy at 2 Gy per fraction with bilateral cochlea contoured for VMAT optimization as an organ at risk. Minimum, mean and maximum planned radiation dose to the cochlea based on tumour and treatment characteristics and dose-volume histogram variables of VMAT plans were analysed.
Results
Mean (standard deviation, SD) cochlear volume was 0.14 (0.06) cm
3
with maximum and mean planned doses of 10.3 (SD = 11.6) Gy and 8.5 (SD = 9.8) Gy, respectively. We found a statistically significant correlation between mean dose received by bilateral cochlea (
P
—0.000,
r
r
ight
—0.84,
r
left
—0.78,
r
midline
—0.92). Tumours of the paranasal sinuses, and the parotids and more advanced T stages were associated with a higher mean dose to cochlea but was not significant statistically. The dose received by the 95% target nodal volume (D
95%
) showed a significant correlation with the cochlear mean dose (
P
—0.000,
r
right
—0.85,
r
left
—0.77,
r
midline
—0.93)
Conclusion
With VMAT we have achieved a better sparing of cochlea. The mean dose to the cochlea of one side significantly differed from the other side in patients with lateralized cancers. D
95%
of nodal volume also showed a significant correlation with the cochlear mean dose.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-021-06950-y</identifier><identifier>PMID: 34160665</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Head and Neck ; Head and Neck Surgery ; Medicine ; Medicine & Public Health ; Neurosurgery ; Otorhinolaryngology</subject><ispartof>European archives of oto-rhino-laryngology, 2022-04, Vol.279 (4), p.2019-2028</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-c81d712cfec00fa99c5c96ec27223b6dd7f8028e66ab0f0a59142e6b2868234b3</cites><orcidid>0000-0002-4339-7541</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-021-06950-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-021-06950-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34160665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Das, Nidhin</creatorcontrib><creatorcontrib>Patro, Sourabha Kumar</creatorcontrib><creatorcontrib>Kaushal, Darwin</creatorcontrib><creatorcontrib>Pareek, Puneet</creatorcontrib><creatorcontrib>Dixit, Abhinav</creatorcontrib><creatorcontrib>Kombathula, Sri Harsha</creatorcontrib><creatorcontrib>Soni, Kapil</creatorcontrib><creatorcontrib>Sharma, Vidhu</creatorcontrib><creatorcontrib>Goyal, Amit</creatorcontrib><title>Correlation of tumour and treatment characteristics to dose received by cochlea in volumetric arc therapy</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Purpose
This is a radiation field simulation study using CT images designed to see the cochlear dosimetry and its correlation with tumour and treatment characteristics during radiotherapy for head and neck cancers (HNC) for identifying the factors associated with a higher dose delivered to the cochlea.
Methods
From 2018 to 2020, 80 patients with HNC underwent volumetric arc therapy (VMAT) to a dose of 66–70 Gy at 2 Gy per fraction with bilateral cochlea contoured for VMAT optimization as an organ at risk. Minimum, mean and maximum planned radiation dose to the cochlea based on tumour and treatment characteristics and dose-volume histogram variables of VMAT plans were analysed.
Results
Mean (standard deviation, SD) cochlear volume was 0.14 (0.06) cm
3
with maximum and mean planned doses of 10.3 (SD = 11.6) Gy and 8.5 (SD = 9.8) Gy, respectively. We found a statistically significant correlation between mean dose received by bilateral cochlea (
P
—0.000,
r
r
ight
—0.84,
r
left
—0.78,
r
midline
—0.92). Tumours of the paranasal sinuses, and the parotids and more advanced T stages were associated with a higher mean dose to cochlea but was not significant statistically. The dose received by the 95% target nodal volume (D
95%
) showed a significant correlation with the cochlear mean dose (
P
—0.000,
r
right
—0.85,
r
left
—0.77,
r
midline
—0.93)
Conclusion
With VMAT we have achieved a better sparing of cochlea. The mean dose to the cochlea of one side significantly differed from the other side in patients with lateralized cancers. D
95%
of nodal volume also showed a significant correlation with the cochlear mean dose.</description><subject>Head and Neck</subject><subject>Head and Neck Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kLtu3DAQRYkgRrxe-wdSGCzTyBlSFCWWwSJ-AAukSWqCGo28XEjimqQM6O-jeJ2Uqaa4515gDmOfBdwJgPprAlBQFSBFAdpUUCwf2EaoUhWqlvoj24Ap60Kpur5kVykdAaBSpvzELkslNGhdbZjfhRhpcNmHiYee53kMc-Ru6niO5PJIU-Z4cNFhpuhT9ph4DrwLiXgkJP9KHW8XjgEPAznuJ_4ahnmkHD1yF5HnA0V3Wq7ZRe-GRDfvd8t-3X__uXss9j8ennbf9gVK0-QCG9HVQmJPCNA7Y7BCowllLWXZ6q6r-wZkQ1q7FnpwlRFKkm5loxtZqrbcsi_n3VMMLzOlbEefkIbBTRTmZGWllKrMKmNF5RnFGFKK1NtT9KOLixVg_yi2Z8V2VWzfFNtlLd2-78_tSN2_yl-nK1CegbRG0zNFe1yVTuvP_5v9DcT4iSc</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Das, Nidhin</creator><creator>Patro, Sourabha Kumar</creator><creator>Kaushal, Darwin</creator><creator>Pareek, Puneet</creator><creator>Dixit, Abhinav</creator><creator>Kombathula, Sri Harsha</creator><creator>Soni, Kapil</creator><creator>Sharma, Vidhu</creator><creator>Goyal, Amit</creator><general>Springer Berlin Heidelberg</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4339-7541</orcidid></search><sort><creationdate>20220401</creationdate><title>Correlation of tumour and treatment characteristics to dose received by cochlea in volumetric arc therapy</title><author>Das, Nidhin ; Patro, Sourabha Kumar ; Kaushal, Darwin ; Pareek, Puneet ; Dixit, Abhinav ; Kombathula, Sri Harsha ; Soni, Kapil ; Sharma, Vidhu ; Goyal, Amit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-c81d712cfec00fa99c5c96ec27223b6dd7f8028e66ab0f0a59142e6b2868234b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Head and Neck</topic><topic>Head and Neck Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Das, Nidhin</creatorcontrib><creatorcontrib>Patro, Sourabha Kumar</creatorcontrib><creatorcontrib>Kaushal, Darwin</creatorcontrib><creatorcontrib>Pareek, Puneet</creatorcontrib><creatorcontrib>Dixit, Abhinav</creatorcontrib><creatorcontrib>Kombathula, Sri Harsha</creatorcontrib><creatorcontrib>Soni, Kapil</creatorcontrib><creatorcontrib>Sharma, Vidhu</creatorcontrib><creatorcontrib>Goyal, Amit</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Das, Nidhin</au><au>Patro, Sourabha Kumar</au><au>Kaushal, Darwin</au><au>Pareek, Puneet</au><au>Dixit, Abhinav</au><au>Kombathula, Sri Harsha</au><au>Soni, Kapil</au><au>Sharma, Vidhu</au><au>Goyal, Amit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of tumour and treatment characteristics to dose received by cochlea in volumetric arc therapy</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>279</volume><issue>4</issue><spage>2019</spage><epage>2028</epage><pages>2019-2028</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Purpose
This is a radiation field simulation study using CT images designed to see the cochlear dosimetry and its correlation with tumour and treatment characteristics during radiotherapy for head and neck cancers (HNC) for identifying the factors associated with a higher dose delivered to the cochlea.
Methods
From 2018 to 2020, 80 patients with HNC underwent volumetric arc therapy (VMAT) to a dose of 66–70 Gy at 2 Gy per fraction with bilateral cochlea contoured for VMAT optimization as an organ at risk. Minimum, mean and maximum planned radiation dose to the cochlea based on tumour and treatment characteristics and dose-volume histogram variables of VMAT plans were analysed.
Results
Mean (standard deviation, SD) cochlear volume was 0.14 (0.06) cm
3
with maximum and mean planned doses of 10.3 (SD = 11.6) Gy and 8.5 (SD = 9.8) Gy, respectively. We found a statistically significant correlation between mean dose received by bilateral cochlea (
P
—0.000,
r
r
ight
—0.84,
r
left
—0.78,
r
midline
—0.92). Tumours of the paranasal sinuses, and the parotids and more advanced T stages were associated with a higher mean dose to cochlea but was not significant statistically. The dose received by the 95% target nodal volume (D
95%
) showed a significant correlation with the cochlear mean dose (
P
—0.000,
r
right
—0.85,
r
left
—0.77,
r
midline
—0.93)
Conclusion
With VMAT we have achieved a better sparing of cochlea. The mean dose to the cochlea of one side significantly differed from the other side in patients with lateralized cancers. D
95%
of nodal volume also showed a significant correlation with the cochlear mean dose.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34160665</pmid><doi>10.1007/s00405-021-06950-y</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4339-7541</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-4477 |
| ispartof | European archives of oto-rhino-laryngology, 2022-04, Vol.279 (4), p.2019-2028 |
| issn | 0937-4477 1434-4726 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2544459000 |
| source | SpringerLink Journals |
| subjects | Head and Neck Head and Neck Surgery Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology |
| title | Correlation of tumour and treatment characteristics to dose received by cochlea in volumetric arc therapy |
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