Prognostic Role of FGFR Alterations and FGFR mRNA Expression in Metastatic Urothelial Cancer Undergoing Checkpoint Inhibitor Therapy

To examine the disease-specific survival(DSS) after checkpoint inhibitor(CPI) therapy based on FGFR alterations and FGFR mRNA expression levels in patients with metastatic urothelial cancer(mUCa) within a multi-center cohort. Within a cohort of 72 patients with mUCa from five academic centers in Ger...

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Veröffentlicht in:	Urology (Ridgewood, N.J.) N.J.), 2021-11, Vol.157, p.93-101
Hauptverfasser:	Tully, Karl H., Jütte, Hendrik, Wirtz, Ralph M., Jarczyk, Jonas, Santiago-Walker, Ademi, Zengerling, Friedemann, Breyer, Johannes, Sikic, Danijel, Kriegmair, Maximilian C., von Hardenberg, Jost, Wullich, Bernd, Taubert, Helge, Weyerer, Veronika, Stoehr, Robert, Bolenz, Christian, Burger, Maximilian, Porubsky, Stefan, Hartmann, Arndt, Roghmann, Florian, Erben, Philipp, Eckstein, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents, Immunological - therapeutic use Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - genetics Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - secondary Female Gene Expression Gene Fusion Humans Immune Checkpoint Inhibitors - therapeutic use Kaplan-Meier Estimate Male Mutation Nivolumab - therapeutic use Pilot Projects Prognosis Proportional Hazards Models Receptor, Fibroblast Growth Factor, Type 1 - genetics Receptor, Fibroblast Growth Factor, Type 1 - metabolism Receptor, Fibroblast Growth Factor, Type 2 - genetics Receptor, Fibroblast Growth Factor, Type 2 - metabolism Receptor, Fibroblast Growth Factor, Type 3 - genetics Receptor, Fibroblast Growth Factor, Type 3 - metabolism Receptor, Fibroblast Growth Factor, Type 4 - genetics Receptor, Fibroblast Growth Factor, Type 4 - metabolism Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - metabolism RNA, Messenger - metabolism Survival Rate Urologic Neoplasms - drug therapy Urologic Neoplasms - genetics Urologic Neoplasms - metabolism Urologic Neoplasms - pathology
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