MiR-99b-5p suppressed proliferation of human osteoblasts by targeting FGFR3 in osteoporosis

Osteoporosis is a common skeletal disease characterized by reduced bone mass partially caused by an imbalance between bone resorption and formation. Considering the potential role of microRNAs (miRNAs) in osteoporosis, we attempted to identify deregulated miRNA that participates in the pathogenesis...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society 2021-09, Vol.34 (5), p.1398-1409
Hauptverfasser:	Ding, Muliang, Liu, Bo, Chen, Xia, Ouyang, Zhengxiao, Peng, Dan, Zhou, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomedical and Life Sciences Bone growth Bone mass Bone resorption Cell Biology Cell Proliferation - genetics Cells, Cultured Female Fibroblast growth factor receptors Gene Expression - genetics Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Gynecology Humans Life Sciences Male MicroRNAs MicroRNAs - physiology Middle Aged miRNA mRNA Oncology Osteoblastogenesis Osteoblasts Osteoblasts - physiology Osteogenesis Osteogenesis - genetics Osteogenesis - physiology Osteoporosis Osteoporosis - genetics Osteoporosis - pathology Receptor, Fibroblast Growth Factor, Type 3 - genetics Receptor, Fibroblast Growth Factor, Type 3 - metabolism Reproductive Medicine Research Article Signal transduction Signal Transduction - genetics Signal Transduction - physiology Stem Cells Surgery
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