Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles

Non-viral vectors offer the potential to deliver nucleic acids including mRNA and DNA into cells in vivo. However, designing materials that effectively deliver to target organs and then to desired compartments within the cell remains a challenge. Here we develop polymeric materials that can be optim...

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Veröffentlicht in:	Biomaterials 2021-08, Vol.275, p.120966-120966, Article 120966
Hauptverfasser:	Kaczmarek, James C., Patel, Asha Kumari, Rhym, Luke H., Palmiero, Umberto Capasso, Bhat, Balkrishen, Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Gene delivery Lung mRNA Nanoparticles Non-viral vectors
Online-Zugang:	Volltext
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