Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults
Purpose To compare the effects of 12-week high-intensity interval training (HIIT) and vigorous-intensity continuous training (VICT) on cognitive function, physical fitness, VO 2 max, serum neurotransmitters and neurotrophic factors in overweight and obese elderly individuals. Methods Twenty-nine phy...
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| Veröffentlicht in: | European journal of applied physiology 2021-10, Vol.121 (10), p.2773-2785 |
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| creator | Li, Xi Han, Tianyu Zou, Xu Zhang, Han Feng, Wenpin Wang, Han Shen, Yulin Zhang, Li Fang, Guoliang |
| description | Purpose
To compare the effects of 12-week high-intensity interval training (HIIT) and vigorous-intensity continuous training (VICT) on cognitive function, physical fitness, VO
2
max, serum neurotransmitters and neurotrophic factors in overweight and obese elderly individuals.
Methods
Twenty-nine physically inactive older adults (18 males and 11 females) with a mean age of 64.8 ± 3.9 years were randomly divided into a control group (CON,
n
= 9), an HIIT group (4 × 3 min at 90% VO
2
max interspersed with 3 min at 60% VO
2
max,
n
= 10) and a VICT group (25 min at 70% VO
2
max,
n
= 10) and submitted to 12 weeks of training. Cognitive function questionnaires, physical fitness, VO
2
max, serum neurotransmitters and neurotrophic factors were determined at baseline and post training.
Results
Twelve weeks of HIIT and VICT improved the VO
2
max (4.19 ± 2.21 and 1.84 ± 1.63 mL/kg/min, respectively,
p
= 0.005), sit-and-reach distance (8.7 ± 3.0 and 7.8 ± 3.8 cm,
p
= 0.033), choice reaction time (− 0.115 ± 0.15 and − 0.09 ± 0.15 s,
p
= 0.004) and one-leg stand time (4.4 ± 3.4 and 4.2 ± 4.0 s,
p
0.05).
Conclusion
HIIT is suitable for elderly adults and is more effective than VICT for improving VO
2
max and serum neurotrophin-3 concentrations.
Chinese Clinical Trial Registry number
No. ChiCTR1900022315, date of registration: 4 April 2019 |
| doi_str_mv | 10.1007/s00421-021-04746-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2543707475</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2543707475</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-fd1f0dcd03ca1081e7ad647b3a25647adc3777fa3abb5ddfc4006a6e67e14d743</originalsourceid><addsrcrecordid>eNp9kU-LFDEQxYMo7rr6BTxIwIuX1kon3ek5yrD-gQEvem7SSfVMlu5krKR3mIuf3TSzruDBQ_GK1K9eCh5jrwW8FwD6QwJQtahgLaVVW52esGuh5KZqZa2fPvZic8VepHQHAF0tuufsSiqhOqHaa_ZrF8O-ykgzP_j9ofIhY0g-n_na0b2ZeCbjgw_78mIJTcLEE9Iy84ALxUzxePCWj8bmSKlAHCeHNJ15vEc6YXHN3ATH44AJ-fbgw6rGLVNOL9mz0UwJXz3oDfvx6fb79ku1-_b56_bjrrJSN7kanRjBWQfSGgGdQG1cq_QgTd0UNa5gWo9GmmFonButAmhNi61GoZxW8oa9u_geKf5cMOV-9sniNJmAcUl93SipQSvdFPTtP-hdXCiU6wrVdp1oNmI1rC-UpZgS4dgfyc-Gzr2Afk2nv6TTw1prOv2pLL15sF6GGd3jyp84CiAvQCqjsEf6-_d_bH8DwX2eLw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2568815914</pqid></control><display><type>article</type><title>Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Li, Xi ; Han, Tianyu ; Zou, Xu ; Zhang, Han ; Feng, Wenpin ; Wang, Han ; Shen, Yulin ; Zhang, Li ; Fang, Guoliang</creator><creatorcontrib>Li, Xi ; Han, Tianyu ; Zou, Xu ; Zhang, Han ; Feng, Wenpin ; Wang, Han ; Shen, Yulin ; Zhang, Li ; Fang, Guoliang</creatorcontrib><description>Purpose
To compare the effects of 12-week high-intensity interval training (HIIT) and vigorous-intensity continuous training (VICT) on cognitive function, physical fitness, VO
2
max, serum neurotransmitters and neurotrophic factors in overweight and obese elderly individuals.
Methods
Twenty-nine physically inactive older adults (18 males and 11 females) with a mean age of 64.8 ± 3.9 years were randomly divided into a control group (CON,
n
= 9), an HIIT group (4 × 3 min at 90% VO
2
max interspersed with 3 min at 60% VO
2
max,
n
= 10) and a VICT group (25 min at 70% VO
2
max,
n
= 10) and submitted to 12 weeks of training. Cognitive function questionnaires, physical fitness, VO
2
max, serum neurotransmitters and neurotrophic factors were determined at baseline and post training.
Results
Twelve weeks of HIIT and VICT improved the VO
2
max (4.19 ± 2.21 and 1.84 ± 1.63 mL/kg/min, respectively,
p
= 0.005), sit-and-reach distance (8.7 ± 3.0 and 7.8 ± 3.8 cm,
p
= 0.033), choice reaction time (− 0.115 ± 0.15 and − 0.09 ± 0.15 s,
p
= 0.004) and one-leg stand time (4.4 ± 3.4 and 4.2 ± 4.0 s,
p
<
0.001
) of the elderly participants. The serum concentrations of brain-derived neurotrophic factor (375.5 ± 247.9 and 227.0 ± 137.1 pg/ml,
p
= 0.006), nerve growth factor (33.9 ± 16.7 and 23.3 ± 14.5 pg/ml,
p
= 0.037), neurotrophin-3 (24.2 ± 9.33 and 16.3 ± 5.91 pg/ml,
p
= 0.006) and neurotrophin-4 (10.4 ± 3.8 and 7.8 ± 5.0 pg/ml,
p
= 0.029) increased significantly in the HIIT and VICT groups after training. In addition, compared to VICT, HIIT significantly increased VO
2
max and the serum neurotrophin-3 concentration. Serum concentrations of the neurotransmitters acetylcholine, dopamine and serotonin trended upward with training. No significant change was observed in the cognitive function questionnaire scores (
p
> 0.05).
Conclusion
HIIT is suitable for elderly adults and is more effective than VICT for improving VO
2
max and serum neurotrophin-3 concentrations.
Chinese Clinical Trial Registry number
No. ChiCTR1900022315, date of registration: 4 April 2019</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-021-04746-w</identifier><identifier>PMID: 34148146</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acetylcholine ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Body weight ; Brain-derived neurotrophic factor ; ChiCTR ; ChiCTR1900022315 ; China ; Cognitive ability ; Female ; High-Intensity Interval Training ; Human Physiology ; Humans ; Interval training ; Male ; Middle Aged ; Nerve growth factor ; Nerve Growth Factors - blood ; Neurotransmitters ; Neurotrophic factors ; Neurotrophin 3 ; Neurotrophin 4 ; Obesity ; Obesity - physiopathology ; Occupational Medicine/Industrial Medicine ; Older people ; Original Article ; Overweight ; Overweight - physiopathology ; Oxygen Consumption - physiology ; Physical fitness ; Physical Fitness - physiology ; Physical training ; Serotonin ; Sports Medicine</subject><ispartof>European journal of applied physiology, 2021-10, Vol.121 (10), p.2773-2785</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-fd1f0dcd03ca1081e7ad647b3a25647adc3777fa3abb5ddfc4006a6e67e14d743</citedby><cites>FETCH-LOGICAL-c375t-fd1f0dcd03ca1081e7ad647b3a25647adc3777fa3abb5ddfc4006a6e67e14d743</cites><orcidid>0000-0001-5085-220X ; 0000-0001-5864-9687</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-021-04746-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-021-04746-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34148146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xi</creatorcontrib><creatorcontrib>Han, Tianyu</creatorcontrib><creatorcontrib>Zou, Xu</creatorcontrib><creatorcontrib>Zhang, Han</creatorcontrib><creatorcontrib>Feng, Wenpin</creatorcontrib><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>Shen, Yulin</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Fang, Guoliang</creatorcontrib><title>Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Purpose
To compare the effects of 12-week high-intensity interval training (HIIT) and vigorous-intensity continuous training (VICT) on cognitive function, physical fitness, VO
2
max, serum neurotransmitters and neurotrophic factors in overweight and obese elderly individuals.
Methods
Twenty-nine physically inactive older adults (18 males and 11 females) with a mean age of 64.8 ± 3.9 years were randomly divided into a control group (CON,
n
= 9), an HIIT group (4 × 3 min at 90% VO
2
max interspersed with 3 min at 60% VO
2
max,
n
= 10) and a VICT group (25 min at 70% VO
2
max,
n
= 10) and submitted to 12 weeks of training. Cognitive function questionnaires, physical fitness, VO
2
max, serum neurotransmitters and neurotrophic factors were determined at baseline and post training.
Results
Twelve weeks of HIIT and VICT improved the VO
2
max (4.19 ± 2.21 and 1.84 ± 1.63 mL/kg/min, respectively,
p
= 0.005), sit-and-reach distance (8.7 ± 3.0 and 7.8 ± 3.8 cm,
p
= 0.033), choice reaction time (− 0.115 ± 0.15 and − 0.09 ± 0.15 s,
p
= 0.004) and one-leg stand time (4.4 ± 3.4 and 4.2 ± 4.0 s,
p
<
0.001
) of the elderly participants. The serum concentrations of brain-derived neurotrophic factor (375.5 ± 247.9 and 227.0 ± 137.1 pg/ml,
p
= 0.006), nerve growth factor (33.9 ± 16.7 and 23.3 ± 14.5 pg/ml,
p
= 0.037), neurotrophin-3 (24.2 ± 9.33 and 16.3 ± 5.91 pg/ml,
p
= 0.006) and neurotrophin-4 (10.4 ± 3.8 and 7.8 ± 5.0 pg/ml,
p
= 0.029) increased significantly in the HIIT and VICT groups after training. In addition, compared to VICT, HIIT significantly increased VO
2
max and the serum neurotrophin-3 concentration. Serum concentrations of the neurotransmitters acetylcholine, dopamine and serotonin trended upward with training. No significant change was observed in the cognitive function questionnaire scores (
p
> 0.05).
Conclusion
HIIT is suitable for elderly adults and is more effective than VICT for improving VO
2
max and serum neurotrophin-3 concentrations.
Chinese Clinical Trial Registry number
No. ChiCTR1900022315, date of registration: 4 April 2019</description><subject>Acetylcholine</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body weight</subject><subject>Brain-derived neurotrophic factor</subject><subject>ChiCTR</subject><subject>ChiCTR1900022315</subject><subject>China</subject><subject>Cognitive ability</subject><subject>Female</subject><subject>High-Intensity Interval Training</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Interval training</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve growth factor</subject><subject>Nerve Growth Factors - blood</subject><subject>Neurotransmitters</subject><subject>Neurotrophic factors</subject><subject>Neurotrophin 3</subject><subject>Neurotrophin 4</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Older people</subject><subject>Original Article</subject><subject>Overweight</subject><subject>Overweight - physiopathology</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical fitness</subject><subject>Physical Fitness - physiology</subject><subject>Physical training</subject><subject>Serotonin</subject><subject>Sports Medicine</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU-LFDEQxYMo7rr6BTxIwIuX1kon3ek5yrD-gQEvem7SSfVMlu5krKR3mIuf3TSzruDBQ_GK1K9eCh5jrwW8FwD6QwJQtahgLaVVW52esGuh5KZqZa2fPvZic8VepHQHAF0tuufsSiqhOqHaa_ZrF8O-ykgzP_j9ofIhY0g-n_na0b2ZeCbjgw_78mIJTcLEE9Iy84ALxUzxePCWj8bmSKlAHCeHNJ15vEc6YXHN3ATH44AJ-fbgw6rGLVNOL9mz0UwJXz3oDfvx6fb79ku1-_b56_bjrrJSN7kanRjBWQfSGgGdQG1cq_QgTd0UNa5gWo9GmmFonButAmhNi61GoZxW8oa9u_geKf5cMOV-9sniNJmAcUl93SipQSvdFPTtP-hdXCiU6wrVdp1oNmI1rC-UpZgS4dgfyc-Gzr2Afk2nv6TTw1prOv2pLL15sF6GGd3jyp84CiAvQCqjsEf6-_d_bH8DwX2eLw</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Li, Xi</creator><creator>Han, Tianyu</creator><creator>Zou, Xu</creator><creator>Zhang, Han</creator><creator>Feng, Wenpin</creator><creator>Wang, Han</creator><creator>Shen, Yulin</creator><creator>Zhang, Li</creator><creator>Fang, Guoliang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5085-220X</orcidid><orcidid>https://orcid.org/0000-0001-5864-9687</orcidid></search><sort><creationdate>20211001</creationdate><title>Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults</title><author>Li, Xi ; Han, Tianyu ; Zou, Xu ; Zhang, Han ; Feng, Wenpin ; Wang, Han ; Shen, Yulin ; Zhang, Li ; Fang, Guoliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-fd1f0dcd03ca1081e7ad647b3a25647adc3777fa3abb5ddfc4006a6e67e14d743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetylcholine</topic><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body weight</topic><topic>Brain-derived neurotrophic factor</topic><topic>ChiCTR</topic><topic>ChiCTR1900022315</topic><topic>China</topic><topic>Cognitive ability</topic><topic>Female</topic><topic>High-Intensity Interval Training</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Interval training</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve growth factor</topic><topic>Nerve Growth Factors - blood</topic><topic>Neurotransmitters</topic><topic>Neurotrophic factors</topic><topic>Neurotrophin 3</topic><topic>Neurotrophin 4</topic><topic>Obesity</topic><topic>Obesity - physiopathology</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Older people</topic><topic>Original Article</topic><topic>Overweight</topic><topic>Overweight - physiopathology</topic><topic>Oxygen Consumption - physiology</topic><topic>Physical fitness</topic><topic>Physical Fitness - physiology</topic><topic>Physical training</topic><topic>Serotonin</topic><topic>Sports Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xi</creatorcontrib><creatorcontrib>Han, Tianyu</creatorcontrib><creatorcontrib>Zou, Xu</creatorcontrib><creatorcontrib>Zhang, Han</creatorcontrib><creatorcontrib>Feng, Wenpin</creatorcontrib><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>Shen, Yulin</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Fang, Guoliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xi</au><au>Han, Tianyu</au><au>Zou, Xu</au><au>Zhang, Han</au><au>Feng, Wenpin</au><au>Wang, Han</au><au>Shen, Yulin</au><au>Zhang, Li</au><au>Fang, Guoliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>121</volume><issue>10</issue><spage>2773</spage><epage>2785</epage><pages>2773-2785</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Purpose
To compare the effects of 12-week high-intensity interval training (HIIT) and vigorous-intensity continuous training (VICT) on cognitive function, physical fitness, VO
2
max, serum neurotransmitters and neurotrophic factors in overweight and obese elderly individuals.
Methods
Twenty-nine physically inactive older adults (18 males and 11 females) with a mean age of 64.8 ± 3.9 years were randomly divided into a control group (CON,
n
= 9), an HIIT group (4 × 3 min at 90% VO
2
max interspersed with 3 min at 60% VO
2
max,
n
= 10) and a VICT group (25 min at 70% VO
2
max,
n
= 10) and submitted to 12 weeks of training. Cognitive function questionnaires, physical fitness, VO
2
max, serum neurotransmitters and neurotrophic factors were determined at baseline and post training.
Results
Twelve weeks of HIIT and VICT improved the VO
2
max (4.19 ± 2.21 and 1.84 ± 1.63 mL/kg/min, respectively,
p
= 0.005), sit-and-reach distance (8.7 ± 3.0 and 7.8 ± 3.8 cm,
p
= 0.033), choice reaction time (− 0.115 ± 0.15 and − 0.09 ± 0.15 s,
p
= 0.004) and one-leg stand time (4.4 ± 3.4 and 4.2 ± 4.0 s,
p
<
0.001
) of the elderly participants. The serum concentrations of brain-derived neurotrophic factor (375.5 ± 247.9 and 227.0 ± 137.1 pg/ml,
p
= 0.006), nerve growth factor (33.9 ± 16.7 and 23.3 ± 14.5 pg/ml,
p
= 0.037), neurotrophin-3 (24.2 ± 9.33 and 16.3 ± 5.91 pg/ml,
p
= 0.006) and neurotrophin-4 (10.4 ± 3.8 and 7.8 ± 5.0 pg/ml,
p
= 0.029) increased significantly in the HIIT and VICT groups after training. In addition, compared to VICT, HIIT significantly increased VO
2
max and the serum neurotrophin-3 concentration. Serum concentrations of the neurotransmitters acetylcholine, dopamine and serotonin trended upward with training. No significant change was observed in the cognitive function questionnaire scores (
p
> 0.05).
Conclusion
HIIT is suitable for elderly adults and is more effective than VICT for improving VO
2
max and serum neurotrophin-3 concentrations.
Chinese Clinical Trial Registry number
No. ChiCTR1900022315, date of registration: 4 April 2019</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34148146</pmid><doi>10.1007/s00421-021-04746-w</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-5085-220X</orcidid><orcidid>https://orcid.org/0000-0001-5864-9687</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1439-6319 |
| ispartof | European journal of applied physiology, 2021-10, Vol.121 (10), p.2773-2785 |
| issn | 1439-6319 1439-6327 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2543707475 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acetylcholine Aged Biomedical and Life Sciences Biomedicine Body weight Brain-derived neurotrophic factor ChiCTR ChiCTR1900022315 China Cognitive ability Female High-Intensity Interval Training Human Physiology Humans Interval training Male Middle Aged Nerve growth factor Nerve Growth Factors - blood Neurotransmitters Neurotrophic factors Neurotrophin 3 Neurotrophin 4 Obesity Obesity - physiopathology Occupational Medicine/Industrial Medicine Older people Original Article Overweight Overweight - physiopathology Oxygen Consumption - physiology Physical fitness Physical Fitness - physiology Physical training Serotonin Sports Medicine |
| title | Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A44%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20high-intensity%20interval%20training%20increases%20serum%20neurotrophic%20factors%20in%20elderly%20overweight%20and%20obese%20Chinese%20adults&rft.jtitle=European%20journal%20of%20applied%20physiology&rft.au=Li,%20Xi&rft.date=2021-10-01&rft.volume=121&rft.issue=10&rft.spage=2773&rft.epage=2785&rft.pages=2773-2785&rft.issn=1439-6319&rft.eissn=1439-6327&rft_id=info:doi/10.1007/s00421-021-04746-w&rft_dat=%3Cproquest_cross%3E2543707475%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2568815914&rft_id=info:pmid/34148146&rfr_iscdi=true |